Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Do copper(I) complexes with conjugates of phosphine-peptide carriers can cause selective cancer cells death? Synthesis, physicochemical and biological properties.

2016/23/D/ST5/00269

Keywords:

selective transport copper(I) complexes phosphines cytotoxcicity bimolecules interations peptides

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Urszula Komarnicka 

Number of co-investigators in the project: 4

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 452 800 PLN

Project start date (Y-m-d): 2017-07-12

Project end date (Y-m-d): 2021-07-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Linia próżniowa do syntez wraz z wyposażeniam (12 500 PLN)
  2. Oprogramowanie statystyczne (4 950 PLN)
  3. Dewar do przechowywania ciekłego azotu (7 500 PLN)
  4. Spektrometr UVVis (160 000 PLN)
  5. Waga analityczna (10 000 PLN)
  6. Mieszadło magnetyczne z ogrzewaniem (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  1. Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol
    Authors:
    Magdalena Malik, Dariusz C. Bieńko, Urszula K. Komarnicka, Agnieszka Kyzioł, Magdalena Dryś, Anna Świtlicka, Edyta Dyguda-Kazimierowicz, Wiktoria Jedwabny
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2021, tom: 215, strony: 111311-), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2020.111311 - link to the publication
  2. Anticancer potency of novel organometallic Ir(iii) complexes with phosphine derivatives of fluoroquinolones encapsulated in polymeric micelles
    Authors:
    Sandra Kozieł, Urszula K. Komarnicka, Aleksandra Ziółkowska, Agnieszka Skórska-Stania, Barbara Pucelik, Michał Płotek, Victor Sebastian, Alina Bieńko, Grażyna Stochel and Agnieszka Kyzioł
    Academic press:
    Inorganic Chemistry Frontiers (rok: 2020, tom: 7, strony: 3386-3401), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D0QI00538J - link to the publication
  3. Cu(II) Complexes with FomA Protein Fragments of Fusobacterium Nucleatum Increase Oxidative Stress and Malondialdehyde Level
    Authors:
    Monika K. Lesiów, Piotr Pietrzyk, Agnieszka Kyzioł, Urszula K. Komarnicka
    Academic press:
    Chemical Research in Toxicology (rok: 2019, tom: 32, strony: 2227-2237), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.chemrestox.9b00269 - link to the publication
  4. ROS-mediated lipid peroxidation as a result of Cu(ii) interaction with FomA protein fragments of F. nucleatum: relevance to colorectal carcinogenesis
    Authors:
    Monika Katarzyna Lesiów, Urszula Katarzyna Komarnicka, Agnieszka Kyzioł, Alina Bieńko, Piotr Pietrzyk
    Academic press:
    Metallomics (rok: 2019, tom: 11, strony: 2066-2077), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9mt00179d - link to the publication
  5. Selective Cu(I) complex with phosphine-peptide (SarGly) conjugate contra breast cancer: Synthesis, spectroscopic characterization and insight into cytotoxic action
    Authors:
    Urszula K. Komarnicka, Sandra Kozieł, Radosław Starosta, Agnieszka Kyzioł
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2018, tom: 186, strony: 162-175), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2018.06.009 - link to the publication
  6. Therapeutic Potential of a Water-Soluble Silver-Diclofenac Coordination Polymer on 3D Pancreatic Cancer Spheroids
    Authors:
    Sabina W. Jaros, Urszula K. Komarnicka, Agnieszka Kyzioł, Barbara Pucelik, Dmytro S. Nesterov, Alexander M. Kirillov and Piotr Smoleński
    Academic press:
    Journal of Medicinal Chemistry , Wydawca: American Chemical Society
    Status:
    Submitted
    DOI:
    BRAK - link to the publication
  7. Antibacterial activity and action mode of Cu(I) and Cu(II) complexes with phosphines derived from fluoroquinolone against clinical and multidrug-resistant bacterial strains
    Authors:
    Katarzyna Guz-Regner, Urszula Katarzyna Komarnicka, Bożena Futoma-Kołoch, Maciej Wernecki, Magdalena Cal, Sandra Kozieł, Aleksandra Ziółkowska, Gabriela Bugla-Płoskońska
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 210, strony: 111124), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2020.111124 - link to the publication
  8. Interaction between DNA, albumin and apo-transferrin and iridium(III) complexes with phosphines derived from fluoroquinolones as a potent anticancer drug.
    Authors:
    Kozieł Sandra Amanda, Lesiów Monika Katarzyna, Wojtala Daria, Dyguda-Kazimierowicz Edyta, Bieńko Dariusz, Komarnicka Urszula Katarzyna
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 685/1-685/25), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14070685 - link to the publication
  9. Coordination properties of Cu(II) ions towards the peptides based on the His-Xaa-His motif from Fusobacterium nucleatum P1 protein
    Authors:
    Katarzyna Krupa, Maria Korabik, Teresa Kowalik-Jankowska
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2019, tom: 201, strony: 110819/1-110819/12), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110819 - link to the publication
  10. L-argininato copper(II) complexes in solution exert significant selective anticancer and antimicrobial activities
    Authors:
    Agnieszka Wojciechowska, Agnieszka Szuster-Ciesielska, Monika Sztandera, Romualda Bregier-Jarzębowska, Anna Jarząb, Tomasz Rojek, Urszula K. Komarnicka, Agnieszka Bojarska-Junak, Julia Jezierska
    Academic press:
    Applied Organometallic Chemistry (rok: 2020, tom: 34, strony: 45307), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/aoc.5698 - link to the publication
  11. Evaluation of anticancer activity in vitro of a stable copper(I) complex with phosphine-peptide conjugate.
    Authors:
    Urszula K. Komarnicka, Barbara Pucelik, Monika Lesiów, Daria Wojtala, Grażyna Stochel, Agnieszka Kyzioł
    Academic press:
    Scientific Reports , Wydawca: Nature
    Status:
    Submitted
    DOI:
    brak - link to the publication
  12. Antybiotyki fluorochinolonowe i ich modyfikacje strukturalne = Fluoroquinolone antibiotics and their structural modifications.
    Authors:
    Komarnicka Urszula K., Walencik Paulina K., Lesiów Monika K., Krupa Katarzyna
    Academic press:
    Wiadomości Chemiczne (rok: 2018, tom: 72, strony: 543-561), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  13. Copper(I) complexes with phosphines P(p-OCH3-Ph)2CH2OH and P(p-OCH3-Ph)2CH2SarGly. Synthesis, multimodal DNA interactions, and prooxidative and in vitro antiproliferative activity
    Authors:
    Urszula K.Komarnicka, Sandra Kozieł, Piotr Zabierowski, Rafał Kruszyński, Monika K.Lesiów, Francesco Tisato, Marina Porchia, Agnieszka Kyzioł
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 203, strony: 110926/1-110926/14), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110926 - link to the publication
  14. Stability of Cu(II) complexes with FomA protein fragments containing two His residues in the peptide chain
    Authors:
    Monika Katarzyna Lesiów, Piotr Pietrzyk, Alina Bieńko, Teresa Kowalik-Jankowska
    Academic press:
    Metallomics (rok: 2019, tom: 11, strony: 1518-1531), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9mt00131j - link to the publication

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