Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of small peptides in copper transport in human organism - interactions with albumin

2016/23/B/ST5/02253

Keywords:

albumin copper peptides

Descriptors:

  • NZ1_3: Biophysics
  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Bal 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 561 000 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2021-07-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termomikser (17 000 PLN)
  2. Bioreaktor z płaszczem wodnym do hodowli mikroorganizmów (130 000 PLN)
  3. Czytnik płytek 96-dołkowych z funkcjami spektrofotometru, spektrofluorymetru, inkubacji w zakresie temperatur i wytrząsania. (140 000 PLN)
  4. Homogenizator ultradźwiękowy (17 000 PLN)
  5. Wirówka laboratoryjna z chłodzeniem i zestawem rotorów (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His
    Authors:
    Paulina Gonzalez, Bertrand Vileno, Karolina Bossak, Youssef El Khoury, Petra Hellwig, Wojciech Bal, Christelle Hureau, Peter Faller
    Academic press:
    Inorganic Chemistry (rok: 2017, tom: 56, strony: 14870-14879), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.7b01996 - link to the publication
  2. Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction
    Authors:
    Iwona Ufnalska, Simon C. Drew, Igor Zhukov, Kosma Szutkowski, Urszula E. Wawrzyniak, Wojciech Wróblewski, Tomasz Frączyk,* and Wojciech Bal*
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 18048-18057), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c02669 - link to the publication
  3. Gly-His-Thr-Asp-Amide, an Insulin-Activating Peptide from the Human Pancreas Is a Strong Cu(II) but a Weak Zn(II) Chelator
    Authors:
    Radosław Kotuniak, Tomasz Frączyk, Piotr Skrobecki, Dawid Płonka, Wojciech Bal
    Academic press:
    Inorganic Chemistry (rok: 2018, tom: 57, strony: 15507-15516), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.8b02841 - link to the publication
  4. Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate
    Authors:
    K. Bossak-Ahmad, M. D. Wiśniewska, W. Bal, S. C. Drew, T. Frączyk
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 5190), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176190 - link to the publication
  5. The Aggregation Pattern of Ab1–40 is Altered by the Presence of N-Truncated Ab4–40 and/or CuII in a Similar Way through Ionic Interactions
    Authors:
    E. Stefaniak, E. Atrian-Blasco, W. Goch, L. Sabater, C. Hureau, W. Bal
    Academic press:
    Chem. Eur. J. (rok: 2021, tom: 27, strony: 2798-2809), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.202004484 - link to the publication
  6. N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications
    Authors:
    Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau,Laurent Raibaut, Wojciech Bal, Peter Faller
    Academic press:
    Chemistry A European Journal (rok: 2018, tom: 24, strony: 8029-8041), Wydawca: ChemPubSoc Europe
    Status:
    Published
    DOI:
    10.1002/chem.201705398 - link to the publication
  7. Ternary Cu2+ Complexes of Human Serum Albumin and Glycyl‑L‑histidyl‑L‑lysine
    Authors:
    Karolina Bossak-Ahmad, Wojciech Bal, Tomasz Frączyk, Simon C. Drew
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 16927-16931), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c03084 - link to the publication
  8. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1
    Authors:
    Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld, Wojciech Bal
    Academic press:
    Metallomics (rok: 2018, tom: 10, strony: 1723-1727), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c8mt00274f - link to the publication
  9. The Cu(II) affinity of the N-terminus of human copper transporter CTR1: Comparison of human and mouse sequences
    Authors:
    Karolina Bossak, Simon C. Drew, Ewelina Stefaniak, Dawid Płonka, Arkadiusz Bonna, Wojciech Bal
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2018, tom: 182, strony: 230-237), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2018.01.011 - link to the publication
  10. The sub-picomolar Cu2+ affinity of human serum albumin
    Authors:
    K. Bossak-Ahmad, T. Frączyk, W. Bal, S. C. Drew
    Academic press:
    ChemBioChem (rok: 2020, tom: 21, strony: 331-334), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201900435 - link to the publication
  11. Triggering Cu-coordination change in Cu(II)-Ala-His-His by external ligands
    Authors:
    P. Gonzalez, K. Bossak-Ahmad, B. Vileno, N. E. Wezynfeld, Y. El Khoury, P. Hellwig, C. Hureau, W. Bal, P. Faller
    Academic press:
    Chem. Commun. (rok: 2019, tom: 55, strony: 8110-8113), Wydawca: Royal Society of Chemistry, UK
    Status:
    Published
    DOI:
    10.1039/c9cc03174j - link to the publication

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