Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Role of small peptides in copper transport in human organism - interactions with albumin

2016/23/B/ST5/02253

Keywords:

albumin copper peptides

Descriptors:

  • NZ1_3:
  • ST5_14:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Bal 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 561 000 PLN

Project start date (Y-m-d): 2017-07-18

Project end date (Y-m-d): 2021-07-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik płytek 96-dołkowych z funkcjami spektrofotometru, spektrofluorymetru, inkubacji w zakresie temperatur i wytrząsania. (140 000 PLN)
  2. Homogenizator ultradźwiękowy (17 000 PLN)
  3. Bioreaktor z płaszczem wodnym do hodowli mikroorganizmów (130 000 PLN)
  4. Termomikser (17 000 PLN)
  5. Wirówka laboratoryjna z chłodzeniem i zestawem rotorów (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  1. Ternary Cu2+ Complexes of Human Serum Albumin and Glycyl‑L‑histidyl‑L‑lysine
    Authors:
    Karolina Bossak-Ahmad, Wojciech Bal, Tomasz Frączyk, Simon C. Drew
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 16927-16931), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c03084 - link to the publication
  2. The sub-picomolar Cu2+ affinity of human serum albumin
    Authors:
    K. Bossak-Ahmad, T. Frączyk, W. Bal, S. C. Drew
    Academic press:
    ChemBioChem (rok: 2020, tom: 21, strony: 331-334), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201900435 - link to the publication
  3. Gly-His-Thr-Asp-Amide, an Insulin-Activating Peptide from the Human Pancreas Is a Strong Cu(II) but a Weak Zn(II) Chelator
    Authors:
    Radosław Kotuniak, Tomasz Frączyk, Piotr Skrobecki, Dawid Płonka, Wojciech Bal
    Academic press:
    Inorganic Chemistry (rok: 2018, tom: 57, strony: 15507-15516), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.8b02841 - link to the publication
  4. N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications
    Authors:
    Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau,Laurent Raibaut, Wojciech Bal, Peter Faller
    Academic press:
    Chemistry A European Journal (rok: 2018, tom: 24, strony: 8029-8041), Wydawca: ChemPubSoc Europe
    Status:
    Published
    DOI:
    10.1002/chem.201705398 - link to the publication
  5. Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction
    Authors:
    Iwona Ufnalska, Simon C. Drew, Igor Zhukov, Kosma Szutkowski, Urszula E. Wawrzyniak, Wojciech Wróblewski, Tomasz Frączyk,* and Wojciech Bal*
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 18048-18057), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c02669 - link to the publication
  6. The Cu(II) affinity of the N-terminus of human copper transporter CTR1: Comparison of human and mouse sequences
    Authors:
    Karolina Bossak, Simon C. Drew, Ewelina Stefaniak, Dawid Płonka, Arkadiusz Bonna, Wojciech Bal
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2018, tom: 182, strony: 230-237), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2018.01.011 - link to the publication
  7. The Aggregation Pattern of Ab1–40 is Altered by the Presence of N-Truncated Ab4–40 and/or CuII in a Similar Way through Ionic Interactions
    Authors:
    E. Stefaniak, E. Atrian-Blasco, W. Goch, L. Sabater, C. Hureau, W. Bal
    Academic press:
    Chem. Eur. J. (rok: 2021, tom: 27, strony: 2798-2809), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.202004484 - link to the publication
  8. Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His
    Authors:
    Paulina Gonzalez, Bertrand Vileno, Karolina Bossak, Youssef El Khoury, Petra Hellwig, Wojciech Bal, Christelle Hureau, Peter Faller
    Academic press:
    Inorganic Chemistry (rok: 2017, tom: 56, strony: 14870-14879), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.7b01996 - link to the publication
  9. Triggering Cu-coordination change in Cu(II)-Ala-His-His by external ligands
    Authors:
    P. Gonzalez, K. Bossak-Ahmad, B. Vileno, N. E. Wezynfeld, Y. El Khoury, P. Hellwig, C. Hureau, W. Bal, P. Faller
    Academic press:
    Chem. Commun. (rok: 2019, tom: 55, strony: 8110-8113), Wydawca: Royal Society of Chemistry, UK
    Status:
    Published
    DOI:
    10.1039/c9cc03174j - link to the publication
  10. N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications
    Authors:
    Paulina Gonzalez, Karolina Bossak, Ewelina Stefaniak, Christelle Hureau,Laurent Raibaut, Wojciech Bal, Peter Faller
    Academic press:
    Chemistry A European Journal (rok: 2018, tom: 24, strony: 8029-8041), Wydawca: ChemPubSoc Europe
    Status:
    Published
    DOI:
    10.1002/chem.201705398 - link to the publication
  11. Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His
    Authors:
    Paulina Gonzalez, Bertrand Vileno, Karolina Bossak, Youssef El Khoury, Petra Hellwig, Wojciech Bal, Christelle Hureau, Peter Faller
    Academic press:
    Inorganic Chemistry (rok: 2017, tom: 56, strony: 14870-14879), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.7b01996 - link to the publication
  12. The N-terminal 14-mer model peptide of human Ctr1 can collect Cu(II) from albumin. Implications for copper uptake by Ctr1
    Authors:
    Ewelina Stefaniak, Dawid Płonka, Simon C. Drew, Karolina Bossak-Ahmad, Kathryn L. Haas, M. Jake Pushie, Peter Faller, Nina E. Wezynfeld, Wojciech Bal
    Academic press:
    Metallomics (rok: 2018, tom: 10, strony: 1723-1727), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c8mt00274f - link to the publication
  13. Ternary Cu(II) Complex with GHK Peptide and Cis-Urocanic Acid as a Potential Physiologically Functional Copper Chelate
    Authors:
    K. Bossak-Ahmad, M. D. Wiśniewska, W. Bal, S. C. Drew, T. Frączyk
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 5190), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176190 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy