Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Auto-immune response, fibrin clot lysis and cardiovascular outcomes

2016/23/B/NZ5/00573

Keywords:

anibodies fibrin cardiovascular disease

Descriptors:

  • NZ5_1:
  • NZ5_3:
  • NZ5_5:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Hieronim Jakubowski 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 015 300 PLN

Project start date (Y-m-d): 2017-07-04

Project end date (Y-m-d): 2021-07-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie specjalistyczne (SigmaPlot 13, SPSS 24, ChemDraw 15) (30 400 PLN)
  2. Zamrażarka niskotemperaturowa (62 000 PLN)
  3. Komputer z oprogramowaniem narzędziowym (9 000 PLN)

Information in the final report

  • Publication in academic press/journals (20)
  • Articles in post-conference publications (17)
  1. Homocysteine modification in protein structure/function and human disease
    Authors:
    Jakubowski H.
    Academic press:
    Physiological Reviews (rok: 2019, tom: 99, strony: 555-604), Wydawca: The American Physiological Society (United States)
    Status:
    Published
    DOI:
    10.1152/physrev.00003.2018 - link to the publication
  2. Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans
    Authors:
    Perła-Kaján J, Borowczyk K, Głowacki R, Nygård O, Jakubowski H
    Academic press:
    FASEB J (rok: 2018, ), Wydawca: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201800346R - link to the publication
  3. The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study
    Authors:
    Majewska K, Kręgielska-Narożna M, Jakubowski H, Szulińska M, Bogdański P.
    Academic press:
    J Clin Med (rok: 2020, tom: 9(4), strony: E998), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040998 - link to the publication
  4. Quantification of homocysteine thiolactone in human saliva and urine by gas chromatography-mass spectrometry
    Authors:
    Piechocka J, Wrońska M, Chwatko G, Jakubowski H, Głowacki R.
    Academic press:
    J Chromatogr B Analyt Technol Biomed Life Sci. (rok: 2020, tom: 1149, strony: 122155), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2020.122155 - link to the publication
  5. Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Lewandowska I, Marczak Ł, Jakubowski H.
    Academic press:
    Antioxidants (Basel) (rok: 2020, tom: 9(12), strony: E1198), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121198 - link to the publication
  6. Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.
    Authors:
    Sikora M, Lewandowska I, Kupc M, Kubalska J, Graban A, Marczak Ł, Kaźmierski R, Jakubowski H.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(12), strony: pii: E3096), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20123096 - link to the publication
  7. Genetic Attenuation of Paraoxonase 1 Activity Induces Proatherogenic Changes in Plasma Proteomes of Mice and Humans
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Lewandowska I, Marczak Ł, Jakubowski H.
    Academic press:
    Antioxidants (Basel) (rok: 2020, tom: 9(12), strony: E1198), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9121198 - link to the publication
  8. Urinary Excretion of Homocysteine Thiolactone and the Risk of Acute Myocardial Infarction in Coronary Artery Disease Patients; the WENBIT trial
    Authors:
    Borowczyk K, Piechocka J, Głowacki R, Dahr I, Midttun Ø, Tell G, Ueland PM, Nygård O, Jakubowski H.
    Academic press:
    J Internal Medicine (rok: 2019, tom: 285, strony: 232-244), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/joim.12834 - link to the publication
  9. The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study
    Authors:
    Majewska K, Kręgielska-Narożna M, Jakubowski H, Szulińska M, Bogdański P.
    Academic press:
    J Clin Med (rok: 2020, tom: 9(4), strony: E998), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9040998 - link to the publication
  10. Homocysteine modification in protein structure/function and human disease
    Authors:
    Jakubowski H.
    Academic press:
    Physiological Reviews (rok: 2019, tom: 99, strony: 555-604), Wydawca: The American Physiological Society (United States)
    Status:
    Published
    DOI:
    10.1152/physrev.00003.2018 - link to the publication
  11. Urinary Excretion of Homocysteine Thiolactone and the Risk of Acute Myocardial Infarction in Coronary Artery Disease Patients; the WENBIT trial
    Authors:
    Borowczyk K, Piechocka J, Głowacki R, Dahr I, Midttun Ø, Tell G, Ueland PM, Nygård O, Jakubowski H.
    Academic press:
    J Internal Medicine (rok: 2019, tom: 285, strony: 232-244), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/joim.12834 - link to the publication
  12. Changes in redox plasma proteome of Pon1-/- mice are exacerbated by a hyperhomocysteinemic diet
    Authors:
    Sikora M, Jakubowski H.
    Academic press:
    Free Radical Biology and Medicine (rok: 2021, tom: 169, strony: 169-180), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2 - link to the publication
  13. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs-/- mice and thrombosis-prone CBS-/- humans
    Authors:
    Sikora M, Lewandowska I, Marczak Ł, Bretes E, Jakubowski H.
    Academic press:
    Sci Rep (rok: 2020, tom: 10(1), strony: 10726), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  14. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease
    Authors:
    Marta Sikora, Paweł Skrzydlewski, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    PLOS ONE (rok: 2022, tom: 17(10), strony: 45672), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1371/journal.pone.0275956 - link to the publication
  15. Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia
    Authors:
    Perła-Kaján J, Jakubowski H.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(13), strony: pii: E3140), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133140 - link to the publication
  16. Quantification of homocysteine thiolactone in human saliva and urine by gas chromatography-mass spectrometry
    Authors:
    Piechocka J, Wrońska M, Chwatko G, Jakubowski H, Głowacki R.
    Academic press:
    J Chromatogr B Analyt Technol Biomed Life Sci. (rok: 2020, tom: 1149, strony: 122155), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2020.122155 - link to the publication
  17. Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia
    Authors:
    Perła-Kaján J, Jakubowski H.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(13), strony: pii: E3140), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133140 - link to the publication
  18. Homocysteine thiolactone contributes to a prognostic value of fibrin clot structure/function in coronary artery disease
    Authors:
    Marta Sikora, Paweł Skrzydlewski, Joanna Perła-Kaján, Hieronim Jakubowski
    Academic press:
    PLOS ONE (rok: 2022, tom: 17(10), strony: 45672), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1371/journal.pone.0275956 - link to the publication
  19. Serum Proteome Alterations in Human Cystathionine β-Synthase Deficiency and Ischemic Stroke Subtypes.
    Authors:
    Sikora M, Lewandowska I, Kupc M, Kubalska J, Graban A, Marczak Ł, Kaźmierski R, Jakubowski H.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(12), strony: pii: E3096), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20123096 - link to the publication
  20. Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs-/- mice and thrombosis-prone CBS-/- humans
    Authors:
    Sikora M, Lewandowska I, Marczak Ł, Bretes E, Jakubowski H.
    Academic press:
    Sci Rep (rok: 2020, tom: 10(1), strony: 10726), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-020-67672-5 - link to the publication
  1. Analiza czynników wpływających na kinetykę powstawania i lizy skrzepów fibrynowych w osoczu pacjentów z chorobami sercowo-naczyniowymi
    Authors:
    Skrzydlewski P, Sikora M, Jakubowski H.
    Conference:
    Nowe Wyzwania Dla Polskiej Nauki - IV Edycja (rok: 2018, ), Wydawca: Creativetime
    Data:
    konferencja 1,12
    Status:
    Published
  2. Sex affects homocysteine modufication at lysine residue 212 of albumin in mice
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    3rd Congress of Polish Biosciences BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21.09
    Status:
    Published
  3. Sex affects homocysteine modufication at lysine residue 212 of albumin in mice
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    3rd Congress of Polish Biosciences BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21.09
    Status:
    Published
  4. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    FASEB SRC on Folic Acid, Vitamin B12, & One-Carbon Metabolism" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  5. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Wróblewski J, Filipkowski RK, Jakubowski H.
    Conference:
    FASEB Conference on Folic Acid, Vitamin B12, and One‐Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  6. Analiza czynników wpływających na poziom przeciwciał przeciw N-homocysteinylowanym białkom u pacjentów z chorobami serocowo-naczyniowymi
    Authors:
    Kupc M, Perła-Kajan J, Jakubowski H.
    Conference:
    Nowe Wyzwania DLa Polskiej Nauki - IV Edycja (rok: 2018, ), Wydawca: Creativetime
    Data:
    konferencja 1,12
    Status:
    Published
  7. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    FASEB SRC on Folic Acid, Vitamin B12, & One-Carbon Metabolism" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  8. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice.
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    FASEB SRC on Folic Acid, Vitamin B12, & One-Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  9. Telomere length is not related to homocysteine and life span in cystathionine-β synthase-deficient mice and humans
    Authors:
    Utyro O, Perła-Kajan, Kubalska J, Kozich V, Jakubowski H.
    Conference:
    3rd Congress of Polish Biosciences BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21.09
    Status:
    Published
  10. Paraoxonase 1 activity affects homocysteine thiolactone levels in renal transplant receipients.
    Authors:
    Perła-Kaján J, Borowczyk K, Bakker SJL, Jakubowski H.
    Conference:
    FASEB conference on "Folic Acid, Vitamin B12& One-Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  11. Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice.
    Authors:
    Sikora M, Marczak Ł, Perła-Kajan J, Jakubowski H.
    Conference:
    FASEB SRC on Folic Acid, Vitamin B12, & One-Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  12. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Witucki Ł, Suszyńska-Zajczyk J, Wróblewski J, Filipkowski RK, Jakubowski H.
    Conference:
    FASEB Conference on Folic Acid, Vitamin B12, and One‐Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  13. Paraoxonase 1 activity affects homocysteine thiolactone levels in renal transplant receipients.
    Authors:
    Perła-Kaján J, Borowczyk K, Bakker SJL, Jakubowski H.
    Conference:
    FASEB conference on "Folic Acid, Vitamin B12& One-Carbon Metabolism" (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 29.07-03.08
    Status:
    Published
  14. Behavioral phenotyping of hyperhomocysteinemic neonates
    Authors:
    Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Joanna Perła-Kajan, Hieronim Jakubowski
    Conference:
    5th International Seminar on Behavioral Methods (rok: 2018, ), Wydawca: Acta Neurobiologiae Experimentalis vol 78 suppl
    Data:
    konferencja 27-29.09
    Status:
    Published
  15. Hyperhomocysteinemia causes cognitive impairment by hyper-activating mTOR and impairing autophagy via the inhibition of Phf8 histone demethylase in mice
    Authors:
    Łukasz Witucki, Joanna Suszyńska-Zajczyk, Jacek Wróblewski, Robert K Filipkowski, Hieronim Jakubowski
    Conference:
    Fourth Annual Rutgers Brain Health Institute Symposium (rok: 2018, ), Wydawca: Rutgers
    Data:
    konferencja 30,11
    Status:
    Published
  16. Homocysteine-thiolactone predicts myocardial infarction in a randomized controlled trial
    Authors:
    Jakubowski H, Borowczyk K, Głowacki R, Perła-Kaján J, Ueland PM, Nygård O.
    Conference:
    Keystone Symposia – Atherosclerosis (rok: 2018, ), Wydawca: nie dotyczy
    Data:
    konferencja 4-8.02
    Status:
    Published
  17. Telomere length is not related to homocysteine and life span in cystathionine-β synthase-deficient mice and humans
    Authors:
    Utyro O, Perła-Kajan, Kubalska J, Kozich V, Jakubowski H.
    Conference:
    3rd Congress of Polish Biosciences BIO2018 (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21.09
    Status:
    Published

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