Projects funded by the NCN
Mechanism of substrate recognition and binding by gamma-secretase on the example of the amyloid precursor protein
2016/23/N/ST4/00378
Keywords:
Alzheimer's disease gamma secretase amyloid precursor protein molecular dynamics
Descriptors:
- ST4_15: Colloid chemistry
- ST4_13: Solid-state chemistry, surface physicochemistry
- NZ1_3: Biophysics
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Politechnika Gdańska, Wydział Chemiczny
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: PRELUDIUM 12 - announced on 2016-09-15
Amount awarded: 131 000 PLN
Project start date (Y-m-d): 2017-08-24
Project end date (Y-m-d): 2021-08-23
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Macierz dyskowa (38 000 PLN)
Information in the final report
- Publication in academic press/journals (1)
- Role of cholesterol in substrate recognition by γ-secretaseAuthors:Łukasz Nierzwicki, Michał Olewniczak, Paweł Chodnicki, Jacek CzubAcademic press:Scientific Reports (rok: 2021, tom: 11, strony: 15213), Wydawca: Springer NatureStatus:PublishedDOI:10.1038/s41598-021-94618-2 - link to the publication