Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Investigation of the chemical composition and mechanisms of antitumor activity of extracts and chemical substances isolated from white birch buds

2016/23/B/NZ7/03360

Keywords:

birch buds metabolome antitumor activity cytotoxicity mechanisms

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_4: Metabolomics
  • NZ8_10: Taxonomy and phylogenetic

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Białostocka, Zamiejscowy Wydział Leśny w Hajnówce

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Walerij Isidorow 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 678 042 PLN

Project start date (Y-m-d): 2017-08-03

Project end date (Y-m-d): 2020-01-02

Project duration:: 29 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny system do chromatografii preparatywnej "Flash" (220 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Cytotoxiciity of triterpene seco-acids from Betula pubescens buds
    Authors:
    Łukasz Szoka, Valery Isidorov*, Jolanta Nazaruk, Marcin Stocki, Leszek Siergiejczyk
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 45301), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24224060 - link to the publication
  2. Cytotoxicity of white birch bud extracts: Perspectives of therapy of tumors
    Authors:
    Valery Isidorov*, Łukasz Szoka, Jolanta Nazaruk
    Academic press:
    PLOS One (rok: 2018, tom: 13(8):e0201949, strony: 1010), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.02201949 - link to the publication
  3. Inheritance of specific secondary volatile metabolites in buds of white birch Betula pendula and Betula pubescens hybrids
    Authors:
    Valery A. Isidorov*, Marcin Stocki, Lidia Vetchinnikova
    Academic press:
    Trees Structure and Function (rok: 2019, tom: 33, strony: 1329-1344), Wydawca: Springer Verlag
    Status:
    Published
    DOI:
    10.1007/s00468-019-01861-2 - link to the publication
  4. Secondary metabolites of Betula pubescens buds: the supposed ecological role and biosynthesis pathways of some of them
    Authors:
    Valery Isidorov, Marcin Stocki, Jolanta Nazaruk, Sławomir Bakier
    Academic press:
    Molecules , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Perspectives of white birch bud extracts for therapy of tumors
    Authors:
    Marcin Stocki, Łukasz Szoka, Jakub Strawa, Valery Isidorov
    Conference:
    7th Edition of International Conference on Pharmacognosy and Medical Plants (rok: 2019, ), Wydawca: EuroSciCon Ltd
    Data:
    konferencja March 11-12, 2019
    Status:
    Published
  2. Pozyskiwanie substancji biologiczne aktywnych z odpadów zrębowych brzozy (Betula spp.) przy pomocy ekstrakcji nadkrytycznym dwutlenkiem węgla
    Authors:
    Marcin Stocki, Walerij Isidorow, Sławomir Bakier
    Conference:
    Konferencja Naukowa Chemików: Łączy nas chemia (rok: 2018, ), Wydawca: Uniwersytet w Białymstoku
    Data:
    konferencja 25-26.05.2018
    Status:
    Published

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