Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Spectral histopathology, FTIR and immunoSERS, for the recognition of biochemical status of pre-metastatic niche and micrometastasis in murine model of breast cancer

2016/23/B/NZ4/01379

Keywords:

cancer micrometastasis murine breast cancer model spectral histopathology FTIR spectroscopy SERS spectroscopy

Descriptors:

  • ST4_3: Molecular architecture and structure
  • NZ4_5: Anatomical pathology
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Kamilla Małek 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 011 050 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2022-02-03

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Licencja programu SOLO+MIA (5 497 PLN)
  2. Obiektyw o powiększeniu 25x do mikroskopu FTIR Agilent model 670 (60 000 PLN)
  3. Wytrząsarka.
  4. Komputer (10 000 PLN)
  5. Licencja Microsoft Office.
  6. Oprogramowanie specjalistyczne (3 szt.) (12 000 PLN)
  7. Wirówka laboratoryjna z regulacją temperatury (20 000 PLN)
  8. Elementy optyczne, elektroniczne i mechaniczne do spektrometrów IR i ramanowskiego (4 szt.) (32 000 PLN)
  9. Elementy optyczne, elektroniczne i mechaniczne do spektrometrów IR i ramanowskiego (2 szt.) (15 000 PLN)
  10. Komputer stacjonarny.
  11. Laptop 2 szt..
  12. Rzutnik multimedialny.
  13. laser do spektrometru ramanowskiego (120 000 PLN)
  14. przenośne dyski o pojemności > 1 TB (2 szt.) (1 200 PLN)
  15. Kontaktowy kontroler temperatury (3 000 PLN)
  16. Rotator (4 000 PLN)
  17. Skaner wiązki laserowej.
  18. dyski przenośne 4 szt..

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (1)
  1. Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs
    Authors:
    A. Blat, E. Wiercigroch, M. Smeda, A. Wislocka,S. Chlopicki, K. Malek
    Academic press:
    Journal of Biophotonics (rok: 2019, tom: 12, strony: 45302), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jbio.201900067 - link to the publication
  2. High and ultra-high definition of infrared spectral histopathologygives an insight into chemical environment of lung metastases inbreast cancer
    Authors:
    Karolina Augustyniak, Karolina Chrabaszcz, Agnieszka Jasztal, Marta Smeda, Guillermo Quintas, Julia Kuligowska, Katarzyna M. Marzec, Kamilla Malek
    Academic press:
    Journal of Biophotonics (rok: 2019, tom: e201800345, strony: 45299), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
    Status:
    Published
    DOI:
    10.1002/jbio.201800345 - link to the publication
  3. Label-free FTIR spectroscopy detects and visualizes the early stage of pulmonary micrometastasis seeded from breast carcinoma
    Authors:
    Karolina Chrabaszcz, Agnieszka Jasztal, Marta Smęda, Bartosz Zieliński, Aneta Blat, Max Diem, Stefan Chlopicki, Kamilla Malek, Katarzyna M. Marzec
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2018, tom: 1864, strony: 3574-3584), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.08.022 - link to the publication
  4. Molecular profiling of the intestinal mucosa and immune cells of the colon by multi-parametric histological techniques
    Authors:
    Łukasz Zadka, Karolina Chrabaszcz, Igor Buzalewicz, Ewelina Wiercigroch, Natalia Glatzel-Plucińska, Łukasz Szleszkowski, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Krzysztof Kurnol, Piotr Dzięgiel, Tomasz Jurek, Kamilla Malek
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 45307), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-90761-y - link to the publication
  5. High-Resolution Fourier Transform Infrared (FT-IR) Spectroscopic Imaging for Detection of Lung Structures and Cancer-Related Abnormalities in a Murine Model
    Authors:
    Karolina Augustyniak, Karolina Chrabaszcz, Marta Smeda, Marta Stojak, Katarzyna M. Marzec, Kamilla Malek
    Academic press:
    Applied Spectroscopy (rok: 2021, ), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    10.1177/00037028211025540 - link to the publication
  6. Multimodal vibrational studies of drug uptake in vitro: Is the whole greater than the sum of their parts?
    Authors:
    David Perez‐Guaita, Karolina Chrabaszcz, Kamilla Malek, Hugh J. Byrne
    Academic press:
    Journal of Biophotonics (rok: 2020, tom: 13, strony: e202000264), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jbio.202000264 - link to the publication
  7. Tracking extracellular matrix remodeling in lungs induced by breast cancer metastasis. Fourier Transform Infrared spectroscopic studies
    Authors:
    K. Chrabaszcz, K. Kaminska, K. Augustyniak, M. Kujdowicz, M. Smeda, A. Jasztal, M. Stojak, K.M. Marzec, K. Malek
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010236 - link to the publication
  8. Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer
    Authors:
    K. Chrabaszcz, K. Kaminska, C.L. Song, J. Morikawa, M. Kujdowicz, E. Michalczyk, M. Smeda, M. Stojak, A. Jasztal, S.G. Kazarian, K. Malek
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13020162 - link to the publication
  1. Vibrational imaging of proteins: changes in the tissues and cells in the lifestyle disease studies
    Authors:
    K. Majzner, K. Czamara, M.Z. Pacia, J. Dybaś, E. Bik, K. Chrąbaszcz, E. Bik, K. Chrabąszcz, E. Wiercigroch, A. Dorosz, A. Wisłocka, K. M. Marzec, K. Małek, M. Barańska
    Book:
    Vibrational Spectroscopy in Protein Research (rok: 2020, tom: 1, strony: 177-218), Wydawca: Elsevier
    Status:
    Published