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Role of mitophagy and assessement of bioenergetic status in podocytes in the development of insulin resistance and impairment of the renal filtration barrier function in the pathogenesis of diabetic nephropathy.

2016/23/D/NZ5/01449

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ4_11: Metabolizm
  • NZ1_1: Biologia molekularna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Irena Audzeyenka

Number of co-investigators in the project: 4

Call

SONATA 12 – announced on 2016-09-15

Amount awarded
988 100 PLN
Project start date
2017-08-10
Project end date
2022-08-09
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Extracellular Flux Analyzer (System do analizy płynu pozakomórkowego). Cost: 370 000 PLN
  2. Homogenizator Dounce (2 pcs). Cost: 3 000 PLN
  3. Termocykler z funkcją gradientu temperatury. Cost: 45 000 PLN
  4. Wirówka z chłodzeniem. Cost: 30 000 PLN
  5. Wytrząsarka orbitralna do mikropłytek. Cost: 7 000 PLN
  6. pH-metr. Cost: 4 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Hyperglycemia alters mitochondrial respiration efficiency and mitophagy in human podocytes.

    Authors:
    Audzeyenka I, Rachubik P, Typiak M, Kulesza T, Topolewska A, Rogacka D, Angielski S, Saleem MA, Piwkowska A.
    Academic press:
    Experimental Cell Research (year: 2021, volume: 407, pages: 112758), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.yexcr.2021.112758 – link to the publication

  2. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

    Authors:
    Audzeyenka I, Rachubik P, Rogacka D, Typiak M, Kulesza T, Angielski S, Rychłowski M, Wysocka M, Gruba N, Lesner A, Saleem MA, Piwkowska A.
    Academic press:
    Biochimica et Biophysica Acta - Molecular Cell Research (year: 2020, volume: 1867(8), pages: 118723), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2020.118723 – link to the publication

  3. PTEN-induced kinase 1 deficiency alters albumin permeability and insulin signaling in podocytes

    Authors:
    Audzeyenka I, Rachubik P, Typiak M, Kulesza T, Kalkowska D, Rogacka D, Rychłowski M, Angielski S, Saleem M, Piwkowska A.
    Academic press:
    Journal of Molecular Medicine (year: 2022, volume: 100, pages: 903-915), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00109-022-02204-4 – link to the publication

  4. Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria.

    Authors:
    Audzeyenka I, Bierżyńska A, Lay AC.
    Academic press:
    Endocrinology (year: 2022, volume: 163, pages: 46034), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1210/endocr/bqab234 – link to the publication

Articles in post-conference publications (5)

  1. Mitophagy involvement in the development of diabetic kidney disease.

    Authors:
    I. Audzeyenka, D. Rogacka, A. Piwkowska, S. Angielski, M. Jankowski.
    Conference:
    XXVII Międzynarodowy Kongres Polskiego Towarzystwa Fizjologicznego (year: 2017, pages: 94), Publisher: Polskie Towarzystwo Fizjologiczne
    Date:
    conference 21-23 września
    Status:
    Published

  2. High glucose alters mitochondrial DNA quantity and bioenergetics in human podocytes.

    Authors:
    Audzeyenka I, Rogacka D, Rachubik P, Angielski S, Piwkowska A.
    Conference:
    Membrane contact sites in health and disease (year: 2018, pages: 61), Publisher: EMBO
    Date:
    conference 21-25 września
    Status:
    Published

  3. PTEN-induced kinase 1 (PINK1) depletion alters mitochondrial efficiency and glycolysis in human podocytes

    Authors:
    Audzeyenka I, Rogacka D, Piwkowska A
    Conference:
    57TH ERA-EDTA CONGRESS (year: 2020, pages: iii1305), Publisher: Oxford University Press
    Date:
    conference 4-9 czerwca
    Status:
    Published

  4. PTEN-induced kinase 1 (PINK1) deficiency impairs insulin signaling pathway in human podocytes.

    Authors:
    I. Audzeyenka, P. Rachubik, M. Typiak, T. Kulesza, D. Kalkowska, D. Rogacka, S. Angielski, A. Piwkowska
    Conference:
    13th International Podocyte Conference (year: 2021, pages: P08), Publisher: NephCure Kidney International
    Date:
    conference 27-31 lipca
    Status:
    Published

  5. Lactate impact on the respiratory efficiency and mitochondrial dynamics in primary rat podocytes.

    Authors:
    Audzeyenka I, Szrejder M, Pikul P, Typiak M, Rogacka D, Piwkowska A
    Conference:
    Energy balance in metabolic disorders (year: 2022, pages: 46-47), Publisher: EMBO
    Date:
    conference 3-6 październik
    Status:
    Published

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