Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of new genetic alterations in high grade paediatric brain tumours using next generation sequencing and evaluation of their usefulness for clinical purposes

2016/23/B/NZ2/03064

Keywords:

pediatric brain tumors molecular markers next generation sequencing high grade tumors glioblastoma choroid plexus carcinoma pineoblastoma oligodendroglioma.

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut "Pomnik - Centrum Zdrowia Dziecka"

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Trubicka 

Number of co-investigators in the project: 11

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 988 800 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2023-01-24

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termocykler z systemem wymiany bloków i gradientem (54 000 PLN)
  2. Komputer do analizy danych uzyskanych w wysokoprzepustowych badań (9 000 PLN)
  3. Licencje dla specjalistycznego oprogramowania (63 000 PLN)
  4. Termomikser (3 500 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (4)
  1. Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups.
    Authors:
    Łastowska Maria, Matyja Eaw, Sobocińska Anna, Wojtaś Bartosz, Niemira Magdalena, Szałkowska Anna, Krętowski Adam, Karkucińska-Więckowska Agnieszka, Kaleta Magdalena, Ejmont Maria, Tarasińska Magdalena, Perek-Polnik Marta, Dembowska-Bagińska Bożenna, Pronicki Maciej, Grajkowska Wiesława, Trubicka Joanna.
    Academic press:
    The journal of pathology. Clinical research. (rok: 2021, tom: Vol. 7, Nr 6, strony: s. 565-576), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/cjp2.236 - link to the publication
  2. Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes.
    Authors:
    Maria Łastowska; Joanna Trubicka; Anna Sobocińska; Bartosz Wojtas; Magdalena Niemira; Anna Szałkowska; Adam Krętowski; Agnieszka Karkucińska-Więckowska; Magdalena Kaleta; Maria Ejmont; Marta Perek-Polnik; Bożenna Dembowska-Bagińska; Wiesława Grajkowska; Ewa Matyja
    Academic press:
    Acta Neuropathologica Communications (rok: 2020, tom: Vol. 8, strony: Article 105), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s40478-020-00084-9 - link to the publication
  3. Molecular markers of pediatric solid tumors-diagnosis, optimizing treatments, and determining susceptibility: current state and future directions.
    Authors:
    Trubicka Joanna, Grajkowska Wiesława, Dembowska-Bagińska Bożenna.
    Academic press:
    Cells (rok: 2022, tom: Vol. 11, Nr 7,, strony: Article 1238), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11071238 - link to the publication
  4. BCOR expression in pediatric pineoblastoma
    Authors:
    Joanna Trubicka, Maria Łastowska, Agnieszka Karkucińska-Więckowska, Magdalena Niemira, Maria Ejmont, Agnieszka Sowińska, Maciej Pronicki, Ewa Matyja, Wiesława Grajkowska
    Academic press:
    Folia Neuropathologica (rok: 2023, ), Wydawca: Termedia
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors.
    Authors:
    Immunohistochemical detection of ALK protein identifies APC mutated medulloblastoma and differentiates the WNT-activated medulloblastoma from other types of posterior fossa childhood tumors.
    Academic press:
    Brain Tumor Pathology (rok: 2019, tom: Vol. 36, Nr 1, strony: 45297), Wydawca: Apringer
    Status:
    Published
    DOI:
    10.1007/s10014-018-0331-2 - link to the publication
  6. Medulloblastoma with transitional features between Group 3 and Group 4 is associated with good prognosis.
    Authors:
    Maria Łastowska; Joanna Trubicka; Magdalena Niemira; Magdalena Paczkowska-Abdulsalam; Agnieszka Karkucińska-Więckowska; Magdalena Kaleta; Monika Drogosiewicz; Marta Perek-Polnik; Adam Krętowski; Bożena Cukrowska; Wiesława Grajkowska; Bożenna Dembowska-Bagińska; Ewa Matyja
    Academic press:
    Journal of Neuro-Oncology (rok: 2018, tom: Vol. 138, Nr 2, strony: 231-240), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11060-018-2797-5 - link to the publication
  7. Constitutional mosaicism of a de novo TP53 mutation in a patient with bilateral choroid plexus carcinoma.
    Authors:
    Joanna Trubicka; Iwona Filipek; Piotr Iwanowski; Małgorzata Rydzanicz; Wiesława Grajkowska; Dorota Piekutowska-Abramczuk; Krystyna Chrzanowska; Agnieszka Karkucińska-Więckowska; Katarzyna Iwanicka-Pronicka; Maciej Pronicki; Maria Łastowska; Rafał Płoski; Bożenna Dembowska-Bagińska
    Academic press:
    Cancer Genetics (rok: 2017, tom: Vol. 216-217, strony: 79 - 85), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.cancergen.201707.001 - link to the publication
  1. The presence of ROS1 fusions are not limited only to infantile hemispheric glioma.
    Authors:
    Trubicka Joanna, Ciołkowski Maciej, Perek-Polnik Marta, Dembowska-Bagińska Bożenna
    Conference:
    20th International Symposium on Pediatric Neuro-Oncology & the SIOPE-BTG. (rok: 2022, ), Wydawca: Oxford University Press
    Data:
    konferencja 11-15.06.2022
    Status:
    Published
  2. ALK expression at the protein level is a marker for the differentiation diagnosis of the WNT-activated type of pediatric medulloblastoma.
    Authors:
    Maria Łastowska; Joanna Trubicka; Magdalena Niemira; Magdalena Paczkowska-Abdulsalam; Agnieszka Karkucińska-Więckowska; Magdalena Kaleta; Monika Drogosiewicz; Magdalena Tarasińska; Marta Perek-Polnik; Adam Krętowski; Bożenna Dembowska-Bagińska; Wiesława Grajkowska; Maciej Pronicki; Ewa Matyja
    Conference:
    18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) (rok: 2018, ), Wydawca: Neuro-Oncology
    Data:
    konferencja 2018.06.30-2018.07.03
    Status:
    Published
  3. Germline mutations in MSH2 gene in pediatric patients with congenital and sporadic glioblastoma.
    Authors:
    Maria Ejmont; Małgorzata Rydzanicz; Wiesława Grajkowska; Marta Perek-Polnik; Agnieszka Sowińska; Magdalena Kozłowska; Maria Łastowska; Maciej Pronicki; Rafał Płoski; Bożenna Dembowska-Bagińska; Joanna Tr
    Conference:
    19th International Symposium on Pediatric Neuro-Oncology (ISPNO 2020) (rok: 2020, ), Wydawca: Oxford University Press
    Data:
    konferencja 2020.12.13-2020.12.16
    Status:
    Published
  4. Constitutional mosaicism of clinically important genetic markers in pediatric brain tumors detected by next-generation sequencing
    Authors:
    Joanna Trubicka; Małgorzata Rydzanicz; Iwona Filipek; Piotr Iwanowski; Wiesława Grajkowska; Maciej Pronicki; Rafał Płoski; Bożenna Dembowska-Bagińska; Maria Łastowska
    Conference:
    18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) (rok: 2018, ), Wydawca: Neuro-Oncology
    Data:
    konferencja 2018.06.30-2018.07.03
    Status:
    Published

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