Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of tyrosine phosphorylation in posttranslational processing and secretion of major virulence factors of Porphyromonas gingivalis

2016/23/N/NZ1/01513

Keywords:

gingipains phosphorylation periodontitis Porphyromonas gingivalis virulence enzymes

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Zuzanna Nowakowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 960 PLN

Project start date (Y-m-d): 2017-07-13

Project end date (Y-m-d): 2020-07-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer niestacjonarny typu laptop.

Information in the final report

  • Publication in academic press/journals (4)
  1. Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis
    Authors:
    Veillard Florian, Sztukowska Maryta, Nowakowska Zuzanna, Mizgalska Danuta, Thøgersen Ida B, Enghild Jan J, Bogyo Matthew, Potempa Barbara, Nguyen Ky-Anh, Potempa Jan
    Academic press:
    Biochimie (rok: 2019, tom: 166, strony: 161-172), Wydawca: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
    Status:
    Published
    DOI:
    10.1016/j.biochi.2019.06.010 - link to the publication
  2. Response regulator PorX coordinates oligonucleotide signalling and gene expression to control the secretion of virulence factors
    Authors:
    Schmitz Claus, Madej Mariusz, Nowakowska Zuzanna, Cuppari Anna, Jacula Anna, Książek Mirosław, Mikruta Katarzyna, Wisniewski Jerzy, Pudelko-Malik Natalia, Saran Anshu, Zeytuni Natalie, Mlynarz Piotr, Lamont Richard, Uson Isabel, Siksnys Virginijus, Potempa Jan, Solà Maria
    Academic press:
    Nucleic Acids Research , Wydawca: Oxford University Press
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  3. Phosphorylation of major Porphyromonas gingivalis virulence factors is crucial for their processing and secretion
    Authors:
    Zuzanna Nowakowska, Mariusz Madej, Sylwia Grad, Tiansong Wang, Murray Hackett, Daniel P. Miller, Richard J. Lamont, Jan Potempa
    Academic press:
    Molecular Oral Microbiology (rok: 2021, tom: 36, strony: 316-326), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/omi.12354 - link to the publication
  4. Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis
    Authors:
    Mariusz Madej, Joshua B R White, Zuzanna Nowakowska, Shaun Rawson, Carsten Scavenius, Jan J Enghild, Grzegorz P Bereta, Karunakar Pothula, Ulrich Kleinekathoefer, Arnaud Baslé, Neil A Ranson, Jan Potempa, Bert van den Berg
    Academic press:
    Nature Microbiology (rok: 2020, tom: 5, strony: 1016-1025), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41564-020-0716-y - link to the publication

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