Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Resonance Raman spectroscopy studies of the in vitro and ex vivo haemoglobin adducts with gasotransmitters in biological systems

2016/23/N/ST4/00929

Keywords:

Pophyrins erythrocytes haemoglobin nitric oxide carbon monoxide hydrogen sulfide

Descriptors:

  • ST4_3: Molecular architecture and structure
  • NZ1_2: Biochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Jakub Dybaś 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 400 PLN

Project start date (Y-m-d): 2017-07-26

Project end date (Y-m-d): 2020-01-25

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Objektyw do pomiarów imersyjnych (16 000 PLN)
  2. chłodziarka GKv Liebherr 242/X31/19 (3 826 PLN)
  3. Dysk twardy przenośny (300 PLN)
  4. Lactate Scout.
  5. Komputer przenośny (3 500 PLN)
  6. Dysk twardy (325 PLN)
  7. Przyrząd wielofunkcyjny Elmetron CX-601.
  8. Zużywalne elementy spektrometru (10 000 PLN)
  9. CompareVOA (15 689 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. Probing Heme Active Sites of Hemoglobin in Functional Red Blood Cells Using Resonance Raman Spectroscopy
    Authors:
    J. Dybas, T. Chiura, K. M. Marzec, P. J. Mak
    Academic press:
    The Journal of Physical Chemistry B (rok: 2021, tom: 125, strony: 3556-3565), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.1c01199 - link to the publication
  2. Spectroscopy-based characterization of Hb–NO adducts in human red blood cells exposed to NO-donor and endothelium-derived NO
    Authors:
    J. Dybas, P. Berkowicz, B. Proniewski, K. Dziedzic-Kocurek, J. Stanek, M. Baranska, S. Chlopicki, K. M. Marzec
    Academic press:
    Analyst (rok: 2018, tom: 143, strony: 4335-4346), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8AN00302E - link to the publication
  3. Raman imaging of haem metabolism in situ in macrophages and Kupffer cells
    Authors:
    J. Dybas, M. Grosicki, M. Baranska, K. M. Marzec
    Academic press:
    Analyst (rok: 2018, tom: 143, strony: 3489-3498), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8AN00282G - link to the publication
  1. 7. Vibrational imaging of proteins: changes in the tissues and cells in the lifestyle disease studies
    Authors:
    K. Majzner, K. Czamara, M. Z. Pacia, J. Dybas, E. Bik, K. Chrabaszcz, E. Wiercigroch, A. Dorosz, A. Wislocka, K. M. Marzec, K. Malek and M. Baranska
    Book:
    Vibrational Spectroscopy in Protein Research (rok: 2020, tom: Rozdział 7, strony: 177-218), Wydawca: Academic Press
    Status:
    Published

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