Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Patophysiology of depression: molecular regulation of melatonin homeostasis

2016/23/B/NZ5/02634

Keywords:

depression melatonin diagnostics

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Monika Dmitrzak-Węglarz 

Number of co-investigators in the project: 8

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 194 500 PLN

Project start date (Y-m-d): 2017-09-04

Project end date (Y-m-d): 2022-09-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Adaptery do robota (8 szt.) (28 000 PLN)
  2. System kontroli jakości kwasów nukleinowych i białek (158 000 PLN)
  3. System płuczący.
  4. Platforma do oznaczeń multipleksowych Luminex (model Magpix).
  5. Termocykler gradientowy (40 000 PLN)
  6. ThermoMixer C (13 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (6)
  1. Differences in the Clinical Picture in Women with a Depressive Episode in the Course of Unipolar and Bipolar Disorder
    Authors:
    Bilska K, Pawlak J, Kapelski P, Narożna B, Zakowicz P, Szczepankiewicz A, Skibińska M, Dmitrzak-Weglarz M
    Academic press:
    Journal o Clinical Medicine (rok: 2021, tom: 10(4), strony: 676), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10040676. - link to the publication
  2. Methylation of melatonin receptors in patients with unipolar and bipolar depression
    Authors:
    Lesickaa M, Dmitrzak-Weglarz M, Jablonska E, Wieczorek E, Kapelski P , Szczepankiewicz A , Pawlak J , Reszka E
    Academic press:
    Mechanisms of Ageing and Development (rok: 2023, tom: 211, strony: 111776), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2023.111776 - link to the publication
  3. Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis - Current Status
    Authors:
    Dmitrzak-Weglarz M, Reszka E
    Academic press:
    Neuropsychobiology (rok: 2017, tom: 76, strony: 117-129), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000489470 - link to the publication
  4. ProBDNF as an Indicator of Improvement among Women with Depressive Episodes
    Authors:
    Zwolińska W, Skibinska M, Słopień A, Dmitrzak-Węglarz M.
    Academic press:
    Metabolites (rok: 2022, tom: 12(4), strony: 358), Wydawca: MDPI
    Status:
    Published
    DOI:
    metabo12040358 - link to the publication
  5. Transcripts of orphan nuclear receptor (NR4A1) & potassium channel (KCNK17) genes as new potential biomarkers for depression
    Authors:
    M. Dmitrzak-Weglarza, A. Szczepankiewicza, P. Kapelski, J. Chaberska, K. Kwiatkowska, J. Duda, S. Dziuda, M. Skibinska, E. Reszka, J. Pawlak
    Academic press:
    Meta Gene (rok: 2020, tom: 26, strony: 100786), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mgene.2020.100786 - link to the publication
  6. Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse
    Authors:
    Banach E, Pawlak J, Kapelski P, Szczepankiewicz A, Rajewska-Rager A, Skibinska M, Czerski P, Twarowska-Hauser J, Dmitrzak-Weglarz M
    Academic press:
    Journal of Affective Disorders (rok: 2018, tom: 241, strony: 142-146), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jad.2018.07.080 - link to the publication
  7. Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression
    Authors:
    Dmitrzak-Weglarz M, Szczepankiewicz A, Rybakowski J, Kapelski P, Bilska K, Skibinska M, Reszka E, Lesicka M, Jablonska E, Wieczorek E, Pawlak j
    Academic press:
    Pharmacopsychiatry (rok: 2021, tom: 54(6):., strony: 261-268), Wydawca: Thieme
    Status:
    Published
    DOI:
    10.1055/a-1546-9483 - link to the publication
  8. Molecular Regulation of the Melatonin Biosynthesis Pathway in Unipolar and Bipolar Depression
    Authors:
    Dmitrzak-Weglarz M, Banach E, Bilska K, Narozna B, Szczepankiewicz A, Reszka E, Jablonska E, Kapelski P, Skibinska S, Pawlak J
    Academic press:
    Frontiers in Pharmacology (rok: 2021, tom: 12, strony: 666541), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2021.666541 - link to the publication
  9. An altered global DNA methylation status in women with depression
    Authors:
    Reszka E, Jabłońska E, Lesicka M, Wieczorek E, Kapelski P, Szczepankiewicz A, Pawlak J, Dmitrzak-Węglarz M
    Academic press:
    J Psychiatr Res (rok: 2021, tom: 137, strony: 283-289), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    j.jpsychires.2021.03.003 - link to the publication
  10. Transcriptomic profiling as biological markers of depression – A pilot study in unipolar and bipolar women
    Authors:
    Dmitrzak-Weglarz M, Szczepankiewicz A, Rybakowski J, Kapelski P, Bilska K, Skibinska M, Reszka E, Lesicka M, Jablonska E, Wieczorek E, Bukowska-Olech E, Pawlak J
    Academic press:
    World J Biol Psychiatry (rok: 2021, tom: 22(10), strony: 744-756), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    15622975.2021.1907715 - link to the publication
  1. Orphan nuclear receptor as candidate biomarker in depression – pilot study
    Authors:
    J. Chaberska, K. Kwiatkowska, J. Duda, B. Naro˙zna, J. Pawlak, A. Szczepankiewicz, P. Kapelski, S. Dziuda, A. Rajewska-Rager, M. Dmitrzak-Weglarz
    Conference:
    The 27th European Congress of Psychiatry (rok: 2019, ), Wydawca: European Psychiatric Association
    Data:
    konferencja 43561
    Status:
    Published
  2. Stressful life events as a trigger factor of a depressive episode
    Authors:
    Karolina Bilska, Joanna Pawlak, Paweł Kapelski, Karolina Wasicka-Przewoźna, Beata Narożna, Monika Dmitrzak-Węglarz
    Conference:
    Psychological Trauma: Global burden on mental and physical health (rok: 2020, ), Wydawca: WPA
    Data:
    konferencja 10-12 grudnia 2020
    Status:
    Published
  3. Zmiany globalnej metylacji jako biomarker depresji
    Authors:
    Dmitrzak Węglarz M, Reszka E, Jabłońska E, Lesicka M, Wieczorek E, Kapelski P, Szczepankiewicz A, Pawlak J
    Conference:
    46 Zjazd PTP: Psychiatria w obliczu zmian (rok: 2021, ), Wydawca: PTP
    Data:
    konferencja 24-26 czerwca
    Status:
    Published
  4. Dysfunction of melatonin expression in depression – pilot study
    Authors:
    M. Dmitrzak-Weglarz1, J. Pawlak1, E. Reszka2, A. Szczepankiewicz1, P. Kapelski1, S. Dziuda1, A. Rajewska-Rager1, J. Duda1, P. Czerski1, J. Hauser1
    Conference:
    The 27th European Congress of Psychiatry (rok: 2019, ), Wydawca: European Psychiatric Association
    Data:
    konferencja 43561
    Status:
    Published
  5. Sleeping and activity patterns correlations with symtoms and course of affective disorders.
    Authors:
    Dmitrzak-Węglarz M, Pawlak J, Reszka E, Kapelski P Dziuda S, Duda J, Szczepankiewicz A, Skibinska M, Rajewska-Rager A, Czerski P, Twarowska-Hauser J
    Conference:
    The 30th Conference of the International Society for Chronobiology (rok: 2019, ), Wydawca: Faculty of Psychology University of Warsaw
    Data:
    konferencja 2-5 lipca 2019
    Status:
    Published
  6. The use of expression microarrays in the search for biomarkers of depression
    Authors:
    MonikaDmitrzak-Weglarz, Joanna Pawlak, Aleksandra Szczepankiewicz, Pawel Kapelski, Sebastian Dziuda, Aleksandra Rajewska-Rager, Joanna Duda, Piotr Czerski, Joanna Hauser
    Conference:
    IX Zjazd Polskiego Towarzystwa Genetyki Człowieka w Bydgoszczy (rok: 2018, ), Wydawca: PTGC
    Data:
    konferencja 13-15 września 2018
    Status:
    Published