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Association of selected, inherited genetic factors with the effectiveness of treatment in head and neck squamous cell cancer patients subjected to radiotherapy and cisplatin-based chemoradiotherapy.

2016/23/B/NZ5/03470

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ2_1: Genetyka molekularna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Dorota Monika Butkiewicz

Number of co-investigators in the project: 7

Call

OPUS 12 – announced on 2016-09-15

Amount awarded
541 000 PLN
Project start date
2017-07-18
Project end date
2023-05-17
Project duration
70 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

  1. Germline Variants in Angiogenesis-Related Genes Contribute to Clinical Outcome in Head and Neck Squamous Cell Carcinoma.

    Authors:
    Butkiewicz D, Gdowicz-Kłosok A, Krześniak M, Rutkowski T, Łasut-Szyszka B, Składowski K.
    Academic press:
    Cancers (Basel) (year: 2022, volume: 14(7), pages: 1844), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14071844 – link to the publication

  2. Association of Genetic Variants in ANGPT/TEK and VEGF/VEGFR with Progression and Survival in Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy or Radiochemotherapy.

    Authors:
    Butkiewicz D, Gdowicz-Kłosok A, Krześniak M, Rutkowski T, Krzywon A, Cortez AJ, Domińczyk I, Składowski K.
    Academic press:
    Cancers (Basel) (year: 2020, volume: 12(6), pages: 1506), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12061506 – link to the publication

  3. DNA Double-Strand Break Response and Repair Gene Polymorphisms May Influence Therapy Results and Prognosis in Head and Neck Cancer Patients

    Authors:
    Butkiewicz D., Krześniak M., Gdowicz-Kłosok A., Składowski K., Rutkowski T.
    Academic press:
    Cancers (year: 2023, volume: 15, pages: 4972), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15204972 – link to the publication

Articles in post-conference publications (16)

  1. Combined BER gene variants are associated with radiochemotherapy results in head and neck cancer patients.

    Authors:
    Butkiewicz D., Krześniak M., Gdowicz-Kłosok A., Rutkowski T., Domińczyk I., Matuszczyk I., Składowski K.
    Conference:
    XXIV Gliwice Scientific Meetings (year: 2020, pages: 81), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 20-21.11.2020
    Status:
    Published

  2. Common variants in DNA damage response genes and treatment outcome in head and neck cancer.

    Authors:
    Gdowicz-Kłosok A., Krzesniak M., Rutkowski T., Domińczyk I., Matuszczyk I., Składowski K., Butkiewicz D.
    Conference:
    The 5th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer. (year: 2020, pages: 44), Publisher: NIO-PIB, Warszawa
    Date:
    conference 23-24.09.2020
    Status:
    Published

  3. Predictive value of variants in DSB repair genes in patients with head and neck cancer receiving radiotherapy and cisplatin-based chemoradiotherapy.

    Authors:
    Butkiewicz D., Krześniak M., Gdowicz-Kłosok A., Rutkowski T., Domińczyk I., Matuszczyk I., Składowski K.
    Conference:
    The 5th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer. (year: 2020, pages: 45), Publisher: NIO-PIB Warszawa
    Date:
    conference 23-24.09.2020
    Status:
    Published

  4. Effect of genetic variation in NHEJ pathway on combination treatment outcome in heas and neck cancer.

    Authors:
    Gdowicz-Kłosok A., Krześniak M., Rutkowski T., Domińczyk I., Matuszczyk I., Składowski K., Butkiewicz D.
    Conference:
    XXIV Gliwice Scientific Meetings (year: 2020, pages: 80), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 20-21.11.2020
    Status:
    Published

  5. A. Gdowicz-Kłosok, M. Krześniak, T. Rutkowski, B. Łasut-Szyszka, I. Domińczyk, I. Matuszczyk, K. Składowski, D. Butkiewicz. Analiza wariantów genów związanych z angiogenezą jako czynników modulujących proces progresji i rokowanie w raku głowy i szyi.

    Authors:
    A. Gdowicz-Kłosok, M. Krześniak, T. Rutkowski, B. Łasut-Szyszka, I. Domińczyk, I. Matuszczyk, K. Składowski, D. Butkiewicz.
    Conference:
    VI Śląskie Spotkania Naukowe, Podlesice (year: 2019, pages: 6), Publisher: http://gsn.io.gliwice.pl/index.php/ssn
    Date:
    conference 10-11.05.2019
    Status:
    Published

  6. NMR-based metabolomics in real-time monitoring of treatment induced toxicity in head and neck cancer and influence of individual genetic profile.

    Authors:
    107. Boguszewicz Ł, Bieleń A, Ciszek M, Mrochem-Kwarciak J, Wygoda A, Rutkowski T, Butkiewicz D, Krześniak M, Gdowicz-Kłosok A, Kotylak A, Skorupa A, Składowski K, Sokół M.
    Conference:
    15th Annual Conference of the Metabolomics Society, Metabolomics 2019 (year: 2019, pages: 75), Publisher: Metabolomics Society
    Date:
    conference 23-27.06.2019
    Status:
    Published

  7. Wybrane czynniki genetyczne w ocenie ryzyka nawrotu i prognozie u chorych na płaskonabłonkowego raka głowy i szyi

    Authors:
    A. Gdowicz-Kłosok, M. Krześniak, T. Rutkowski, B. Łasut-Szyszka, I. Domińczyk, I. Matuszczyk, K. Składowski, D. Butkiewicz
    Conference:
    Konferencja COI - IV Spotkania z onkologią molekularną i translacyjną. (year: 2019, pages: 26-27), Publisher: COI Warszawa
    Date:
    conference 4-5.04.2019
    Status:
    Published

  8. The MMP and TIMP variants are associated with progression and prognosis in head and neck cancer.

    Authors:
    M. Krześniak, A. Gdowicz-Kłosok, T. Rutkowski, I. Domińczyk, I. Matuszczyk, M. Pietrowska, K. Składowski, D. Butkiewicz
    Conference:
    XXII Gliwice Scientific Meetings, Gliwice (year: 2018, pages: 137), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 16-17.11.2018
    Status:
    Published

  9. Genetic variation in angiogenic growth factors and their receptors may affect therapy results in patients with head and neck squamous cell cancer (HNSCC).

    Authors:
    D. Butkiewicz, A. Gdowicz-Kłosok, B. Łasut-Szyszka, M. Krześniak, T. Rutkowski, I. Domińczyk, I. Matuszczyk, M. Pietrowska, K. Składowski
    Conference:
    XXII Gliwice Scientific Meetings, Gliwice (year: 2018, pages: 143), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 16-17.11.2018
    Status:
    Published

  10. Wpływ polimorficznych wariantów genów szlaku VEGF/VEGFR na skuteczność leczenia pacjentów z nowotworami regionu głowy i szyi – wyniki wstępne.

    Authors:
    A. Gdowicz-Kłosok, M. Krześniak, T. Rutkowski, I. Matuszczyk, I. Domińczyk, M. Pietrowska, K. Składowski, D. Butkiewicz
    Conference:
    V Śląskie Spotkania Naukowe, Bobolice (year: 2018, pages: 46180), Publisher: http://gsn.io.gliwice.pl/index.php/ssn
    Date:
    conference 25-26.05.2018
    Status:
    Published

  11. Impact of angiogenesis-regulating gene polymorphisms on prognosis in head and neck squamous cell carcinoma, HNSCC.

    Authors:
    A. Gdowicz-Kłosok, M. Krześniak, T. Rutkowski, I. Matuszczyk, I. Domińczyk, M. Pietrowska, K. Składowski, D. Butkiewicz
    Conference:
    XXI Gliwice Scientific Meetings, Gliwice (year: 2017, pages: 83), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 17-18.11.2017
    Status:
    Published

  12. Antioxidant and DNA repair gene polymorphisms influence therapy outcome in squamous cell carcinoma of head and neck (HNSCC).

    Authors:
    M. Krześniak, A. Gdowicz-Kłosok, T. Rutkowski, I. Matuszczyk, I. Domińczyk, M. Pietrowska, K. Składowski, D. Butkiewicz
    Conference:
    XXI Gliwice Scientific Meetings, Gliwice (year: 2017, pages: 107), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 17-18.11.2017
    Status:
    Published

  13. Inherited variation in MRN complex genes contributes to progression in unresected head and neck cancer treated with radiotherapy

    Authors:
    D. Butkiewicz, M. Krześniak, A. Gdowicz-Kłosok, T. Rutkowski, I. Domińczyk, I. Matuszczyk, M. Pietrowska, K. Składowski
    Conference:
    XXIII Gliwice Scientific Meetings, Gliwice (year: 2019, pages: 112), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 22-23.11.2019
    Status:
    Published

  14. Analiza wpływu wybranych czynników genetycznych na ostry odczyn popromienny u chorych leczonych na nowotwory głowy i szyi.

    Authors:
    Ł. Boguszewicz, D. Butkiewicz, M. Krześniak, A. Gdowicz-Kłosok, T. Rutkowski, J. Mrochem-Kwarciak, M. Ciszek, M. Sokół.
    Conference:
    Perspektywy w onkologii molekularnej - III Zjazd Centrum Onkologii-Instytutu im. M. Skłodowskiej-Curie (year: 2018, pages: 22), Publisher: COI Warszawa
    Date:
    conference 5-6.04.2018
    Status:
    Published

  15. Polymorphisms in angiogenesis-related genes and clinical outcome in patients with laryngeal squamous cell carcinoma.

    Authors:
    D. Butkiewicz, M. Krześniak, A. Gdowicz-Kłosok, T. Rutkowski, I. Matuszczyk, I. Domińczyk, K. Składowski
    Conference:
    10th Anniversary International Conference of Contemporary Oncology, Poznań (year: 2018, pages: 40), Publisher: Termedia
    Date:
    conference 21-23.03.2018
    Status:
    Published

  16. DDR signaling pathway gene polymorphism – the effect on prognosis in radio(chemo)therapy-treated head and neck cancer patients

    Authors:
    A. Gdowicz-Kłosok, B. Łasut-Szyszka, M. Krześniak, T. Rutkowski, I. Domińczyk, I. Matuszczyk, M. Pietrowska, K. Składowski, D. Butkiewicz
    Conference:
    XXIII Gliwice Scientific Meetings, Gliwice (year: 2019, pages: 111), Publisher: http://gsn.io.gliwice.pl/
    Date:
    conference 22-23.11.2019
    Status:
    Published

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