Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Analysis of somatic mutations in miRNA and miRNA-biogenesis genes to identify new therapeutic targets and biomarkers of cancer

2016/22/A/NZ2/00184

Keywords:

miRNA deep sequencing somatic mutations lung cancer

Descriptors:

  • NZ2_1:
  • NZ2_11:
  • NZ5_5:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Kozłowski 

Number of co-investigators in the project: 5

Call: MAESTRO 8 - announced on 2016-06-15

Amount awarded: 3 419 300 PLN

Project start date (Y-m-d): 2017-05-15

Project end date (Y-m-d): 2024-05-14

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (18)
  1. Somatic mutations in miRNA genes in lung cancer – potential functional consequences of non-coding sequence variants
    Authors:
    Galka-Marciniak P, Urbanek-Trzeciak MO, Nawrocka PM, Dutkiewicz A, Giefing M, Lewandowska MA, Kozlowski P
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 793), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11060793 - link to the publication
  2. Consequences of genetic variants in miRNA genes
    Authors:
    Machowska M, Galka-Marciniak P, Kozlowski P
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2022, tom: 20, strony: 6443-6457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2022.11.036 - link to the publication
  3. Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools
    Authors:
    Suszynska M, Ratajska M, Galka-Marciniak P, Ryszkowska A, Wydra D, Debniak J, Jasiak A, Wasag D, Cybulski C, Kozlowski P
    Academic press:
    Cancer Prevention Research (rok: 2022, tom: 15(3), strony: 151-160), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1940-6207.CAPR-21-0295 - link to the publication
  4. BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation
    Authors:
    Suszynska M, Kluzniak W, Wokolorczyk D, Jakubowska A, Huzarski T, Gronwald J, Debniak T, Szwiec M, Ratajska M, Klonowska K, Narod S, Bogdanova N, Dörk T, Lubinski J, Cybulski C, Kozlowski P
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 740), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11060740 - link to the publication
  5. Profile of basal cell carcinoma mutations and copy number alterations- focus on gene-associated noncoding variants
    Authors:
    Nawrocka PM, Galka-Marciniak P, Urbanek-Trzeciak MO, M-Thirusenthilarasan I, Szostak N, Philips A, Susok L, Sand M, Kozlowski P
    Academic press:
    Frontiers in Oncology (rok: 2021, tom: 11, strony: 752579), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fonc.2021.752579 - link to the publication
  6. Essential thrombocythaemia progression to the fibrotic phase is associated with a decrease in JAK2 and PDL1 levels
    Authors:
    Lewandowski K, Kandula Z, Gniot M, Paczkowska E, Nawrocka PM, Wojtaszewska M, Janowski M, Mariak M, Handschuh L, Kozlowski P
    Academic press:
    Annals of Hematology (rok: 2022, tom: 101, strony: 2665-2667), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00277-022-05001-8 - link to the publication
  7. CMC: Cancer miRNA Census - a list of cancer-related miRNA genes
    Authors:
    Suszynska M, Machowska M, FraszczykE, Michalczyk M, Philips A, Galka-Marciniak P, Kozlowski P
    Academic press:
    Nucleic Acids Research (rok: 2024, tom: 52, strony: 1628-1644), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkae017 - link to the publication
  8. BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases
    Authors:
    Suszynska M, Ratajska M, Kozlowski P
    Academic press:
    Journal of Ovarian Research (rok: 2020, tom: 13, strony: 50), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13048-020-00654-3 - link to the publication
  9. Summary of BARD1 Mutations and Precise Estimation of Breast and Ovarian Cancer Risks Associated with the Mutations
    Authors:
    Suszynska M, Kozlowski P
    Academic press:
    Genes (rok: 2020, tom: 11, strony: 798), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes11070798 - link to the publication
  10. BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases
    Authors:
    Suszynska M, Ratajska M, Kozlowski P
    Academic press:
    Journal of Ovarian Research (rok: 2020, tom: 13, strony: 50), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13048-020-00654-3 - link to the publication
  11. A pan-cancer atlas of somatic mutations in miRNA biogenesis genes
    Authors:
    Galka-Marciniak P, Urbanek-Trzeciak MO, Nawrocka PM, Kozlowski P
    Academic press:
    Nucleic Acids Research (rok: 2021, tom: 49, strony: 601-620), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkaa1223 - link to the publication
  12. Consequences of genetic variants in miRNA genes
    Authors:
    Machowska M, Galka-Marciniak P, Kozlowski P
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2022, tom: 20, strony: 6443-6457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2022.11.036 - link to the publication
  13. BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation
    Authors:
    Suszynska M, Kluzniak W, Wokolorczyk D, Jakubowska A, Huzarski T, Gronwald J, Debniak T, Szwiec M, Ratajska M, Klonowska K, Narod S, Bogdanova N, Dörk T, Lubinski J, Cybulski C, Kozlowski P
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: 740), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11060740 - link to the publication
  14. Mutations in the miR-142 gene are not common in myeloproliferative neoplasms
    Authors:
    Galka-Marciniak P, Kandula Z, Tire A, Wegorek W, Gwozdz-Bak K, Handschuh L, Giefing M, Lewandowski K, Kozlowski P
    Academic press:
    Scientific Reports (rok: 2022, tom: 12(1), strony: 10924), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-15162-1 - link to the publication
  15. Pan-cancer analysis of somatic mutations in miRNA genes
    Authors:
    Urbanek-Trzeciak MO, Galka-Marciniak P, Nawrocka PM, Kowal E, Szwec S, Giefing M, Kozlowski P
    Academic press:
    EBioMedicine (rok: 2020, tom: 61, strony: 106031), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ebiom.2020.103051 - link to the publication
  16. qEva-CRISPR: a method for quantitative evaluation of CRISPR/Cas-mediated genome editing in target and off-target sites
    Authors:
    Dabrowska M, Czubak K, Juzwa W, Krzyzosiak WJ, Olejniczak M, Kozlowski P
    Academic press:
    Nucleic Acids Research (rok: 2018, tom: 46(17), strony: e101), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gky505 - link to the publication
  17. Large-scale meta-analysis of mutations identified in panels of breast/ovarian cancer-related genes - Providing evidence of cancer predisposition genes
    Authors:
    Suszynska M, Klonowska K, Jasinska AJ, Kozlowski P
    Academic press:
    Gynecologic Oncology (rok: 2019, tom: 153, strony: 452-462), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ygyno.2019.01.027 - link to the publication
  18. miRMut: Annotation of mutation in miRNA genes from whole-exome or whole-genome sequencing
    Authors:
    Urbanek-Trzeciak MO, Kozlowski P, Galka-Marciniak P
    Academic press:
    STAR Protocols (rok: 2021, tom: 3 (1), strony: 101023), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.xpro.2021.101023 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy