Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Toxicokinetics of xenobiotics in human tissues:integrated research of the behavior of psychoactive substances in bone marrow and alternative autopsy materials

2016/22/E/ST4/00054

Keywords:

psychotropic drugs toxicokinetics metabolite prediction biological materials bone marrow vitreouse humor

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • ST4_8: Organic chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

UNIWERSYTET JAGIELLOŃSKI, Wydział Chemii UNIWERSYTET JAGIELLOŃSKI

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Renata Wietecha-Posłuszny 

Number of co-investigators in the project: 8

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 648 800 PLN

Project start date (Y-m-d): 2017-04-12

Project end date (Y-m-d): 2023-04-11

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. termomikser z wyposazeniem.
  2. laptopy przenosne szt 2.
  3. myjka ultradzwiekowa.
  4. vortekx mikser z wyposażeniem.
  5. mieszadła magnetyczne (3 498 PLN)
  6. licencja na oprogramowanie.
  7. monitor LCD.
  8. ultraczuły system fotojonizacji biopróbek ciekłych i stałych w analizach TOF-MS z analizatorem metabolitów (380 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  • Book publications / chapters in book publications (3)
  1. Determination of carbamazepine and its main metabolite in human hair by capillary electrophoresis and liquid chromatography techniques, both coupled with mass spectrometry
    Authors:
    Aneta Wożniakiewicz, Renata Wietecha-Posłuszny*
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis Open (rok: 2023, tom: 1, strony: 100009), Wydawca: Esevier
    Status:
    Published
    DOI:
    10.1016/j.jpbao.2023.100009 - link to the publication
  2. Differentiation of Isomeric Metabolites of Carbamazepine Based on Acidbase Properties; Experimental Vs Theoretical Approach
    Authors:
    P. Nowak, M. Mitoraj, F. Sagan, R. Wietecha-Posłuszny
    Academic press:
    Journal of Chromatography A (rok: 2021, tom: 1651, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2021.462275 - link to the publication
  3. Spectroscopy as a Useful Tool for the Identification of Changes with Time in Postmortem Vitreous Humor for Forensic Toxicology Purposes
    Authors:
    A. Wójtowicz, A. Mitura, R. Wietecha-Posłuszny*, R. Kurczab, M. Zawadzki
    Academic press:
    Monatshefte für Chemie - Chemical Monthly (rok: 2021, tom: 152, strony: 745-755), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00706-021-02786-8 - link to the publication
  4. A sustainable approach for the stability study of psychotropic substances using vitreous humor and liver as alternative matrices
    Authors:
    Anna Wójtowicz, Marcin Reciak, Paweł Mateusz Nowak, Renata Wietecha‑Posłuszny*
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2022, tom: 414, strony: 6355–6370), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-022-04064-w - link to the publication
  5. Contemporary Trends in Drug Analysis of Vitreous Humor: A critical review
    Authors:
    Anna Wójtowicz, Renata Wietecha-Posłuszny*, Mgdalena Snamina
    Academic press:
    Trends in Analytical Chemistry (rok: 2020, tom: 129, strony: 115935), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2020.115935 - link to the publication
  6. Effective extraction methodology for the isolation of antidepressants from human blood
    Authors:
    M. Świądro, R. Wietecha-Posłuszny, D. Dudek
    Academic press:
    Monatshefte für Chemie - Chemical Monthly (rok: 2020, tom: 151, strony: 1225–1230), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00706-020-02643-0 - link to the publication
  7. Development of a new method for drug detection based on a combination of the dried blood spot method and capillary electrophoresis
    Authors:
    M. Świądro, P. Stelmaszczyk, R. Wietecha-Posłuszny*, D. Dudek
    Academic press:
    J. Chromatogr. B (rok: 2020, tom: 1157, strony: 122339), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2020.122339 - link to the publication
  8. Dried Blood Spots sampling in case samples deprived of hematocrit level information - investigation and calculation strategy
    Authors:
    Alicja Majda, Renata Wietecha-Posłuszny*, Magdalena Świądro, Karolina Mrochem, Paweł Kościelniak
    Academic press:
    Journal of Chromatography B (rok: 2019, tom: 1124, strony: 308-312), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2019.06.025 - link to the publication
  9. Fast and efficient analyses of the post-mortem human blood and bone marrow using DI-SPME/LC-TOF MS method for forensic medicine purposes
    Authors:
    1.Alicja Majda, Karolina Mrochem, Renata Wietecha-Posłuszny*, Marcin Zawadzki, Szczepan Zapotoczny
    Academic press:
    Talanta (rok: 2020, tom: 209, strony: 120533), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2019.120533 - link to the publication
  10. Human bone marrow as a tissue in post-mortem identification and determination of psychoactive substances - Screening methodology
    Authors:
    Renata Wietecha-Posłuszny*, Sofia Lendor, Magdalena Garnysz, Marcin Zawadzki, Paweł Kościelniak
    Academic press:
    Journal of Chromatography B, 1061-1062, 459-467 (2017) (rok: 2017, tom: 1061-1062, strony: 459-467), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2017.08.006 - link to the publication
  11. DESI-MS analysis of human fluids and tissues for forensic applications
    Authors:
    Anna Wójtowicz, Renata Wietecha Posłuszny*
    Academic press:
    Applied Physics A (rok: 2019, tom: 125, strony: 312, 9 stron), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00339-019-2564-2 - link to the publication
  12. New green DI-SPME/CE-MS method for quantitative analysis of selected illicit drugs in human whole blood
    Authors:
    Alicja Chromiec, Klaudia Ordon, Renata Wietecha-Posłuszny*
    Academic press:
    Green Analytical Chemistry (rok: 2023, tom: 5, strony: 100063), Wydawca: Esevier
    Status:
    Published
    DOI:
    10.1016/j.greeac.2023.100063 - link to the publication
  13. Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs
    Authors:
    Magdalena Snamina, Renata Wietecha-Posłuszny*, Marcin Zawadzki
    Academic press:
    Talanta (rok: 2019, tom: 204, strony: 607-612), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2019.06.054 - link to the publication
  14. The DI-SPME Method for Determination of Selected Narcotics and Their Metabolites, and Application to Bone Marrow and Whole Blood Analysis
    Authors:
    Magdalena Świądro, Alicja Chromiec, Marcin Zawadzki, Renata Wietecha-Posłuszny*
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 4116), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27134116 - link to the publication
  15. Direct analysis from dried blood spot card surfaces with direct probe mass spectrometry – Evaluation study
    Authors:
    Anna Wójtowicz, Alicja Majda, Szczepan Zapotoczny, Renata Wietecha‐Posłuszny*
    Academic press:
    Rapid Communications Mass Spectrometry (rok: 2019, tom: 33, strony: 1148-1152), Wydawca: Wiley&Sons, Ltd.
    Status:
    Published
    DOI:
    10.1002/rcm.8447 - link to the publication
  16. White Analytical Chemistry: An Approach to Reconcile the Principles of Green Analytical Chemistry and Functionality
    Authors:
    P. Nowak, R. Wietecha-Posłuszny*, J. Pawliszyn
    Academic press:
    TrAC-TRENDS IN ANALYTICAL CHEMISTRY (rok: 2021, tom: 138, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.trac.2021.116223 - link to the publication
  1. Application of Capillary Electrophoresis to Forensic Analysis
    Authors:
    Michał Woźniakiewicz, Małgorzata Król, Renata Wietecha-Posłuszny
    Book:
    Flow and Capillary Electrophoretic Analysis (rok: 2018, tom: Chapter 19, strony: 411-437), Wydawca: Nova Science Publishers, Inc. New York
    Status:
    Published
  2. Analiza materiału biologicznego z wykorzystaniem metody suchej kropli krwi (DBS)
    Authors:
    A. Wójtowicz, R. Wietecha-Posłuszny, P. Stelamszczyk
    Book:
    Analityka sądowa (rok: 2022, tom: Tom 1 [red.] P. Kościelniak, M, strony: 307-318), Wydawca: Wydawnictwo PWN, Warszawa
    Status:
    Published
  3. Nowoczesne techniki ekstrakcji leków psychotropowych do fazy stałej wykorzystywane w analizach toksykologicznych
    Authors:
    Piotr Barwa, Renata Wietecha-Posłuszny*
    Book:
    Kryminalistyka a nowoczesne technologie (rok: 2019, tom: nie dotyczy, strony: 283-309), Wydawca: Uniwersytet Jagielloński
    Status:
    Published

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