Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Reversal of heart failure during mechanical support of left ventricular function - role of nucleotides and energetics in cardiac cells

2016/22/M/NZ4/00678

Keywords:

Heart failure Regeneration Mechanical unloading Nucleotides Mitochondria

Descriptors:

  • NZ4_11: Metabolism
  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ryszard Smoleński 

Number of co-investigators in the project: 10

Call: HARMONIA 8 - announced on 2016-06-15

Amount awarded: 1 400 100 PLN

Project start date (Y-m-d): 2017-04-21

Project end date (Y-m-d): 2022-10-20

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
    Authors:
    Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano
    Academic press:
    Nature Communications (rok: 2019, tom: 10, strony: 2168), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-019-10175-3 - link to the publication
  2. Nucleotide ecto‑enzyme metabolic pattern and spatial distribution in calcific aortic valve disease; its relation to pathological changes and clinical presentation
    Authors:
    Barbara Kutryb‑Zajac, Patrycja Jablonska, Marcin Serocki, Alicja Bulinska, Paulina Mierzejewska, Daniela Friebe, Christina Alter, Agnieszka Jasztal, Romuald Lango, Jan Rogowski, Rafal Bartoszewski, Ewa M. Slominska, Stefan Chlopicki, Jürgen Schrader, Magdi H. Yacoub, Ryszard T. Smolenski
    Academic press:
    Clinical Research in Cardiology (rok: 2019, tom: 10,1007, strony: https://doi.org/10.1007/s00392-019-01495-x), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00392-019-01495-x - link to the publication
  3. Simultaneous accurate quantification of HO-1, CD39, and CD73 in human calcified aortic valves using multiple enzyme digestion - filter aided sample pretreatment (MED-FASP) method and targeted proteomics.
    Authors:
    Olkowicz M, Jablonska P, Rogowski J, Smolenski RT.
    Academic press:
    Talanta (rok: 2018, tom: 128, strony: 492-499), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2018.01.044 - link to the publication
  4. Beneficial Effects of RNS60 in Cardiac Ischemic Injury.
    Authors:
    Zabielska-Kaczorowska MA, Wierzbicka B, Kalmes A, Slominska EM, Yacoub MH, Smolenski RT
    Academic press:
    Curr Issues Mol Biol. (rok: 2022, tom: 44, strony: 4877-4887), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cimb44100331 - link to the publication
  5. Novel Targets for a Combination of Mechanical Unloading with Pharmacotherapy in Advanced Heart Failure
    Authors:
    Jedrzejewska A, Braczko A, Kawecka A, Hellmann M, Siondalski P, Slominska E, Kutryb-Zajac B, Yacoub MH, Smolenski RT
    Academic press:
    Int. J. Mol. Sci (rok: 2022, tom: 23, strony: 9886), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23179886 - link to the publication
  6. Purine Nucleotides Metabolism and Signaling in Huntington's Disease: Search for a Target for Novel Therapies
    Authors:
    Marta Tomczyk 1,* , Talita Glaser 2, Ewa M. Slominska 1 , Henning Ulrich 2 and Ryszard T. Smolenski 1,*
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6545), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126545 - link to the publication
  7. Huntingtin protein maintains balanced energetics in mouse cardiomyocytes
    Authors:
    Marta Tomczyk , Talita Glaser , Henning Ulrich , Ewa M. Slominska & Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides & Nucleic Acids (rok: 2020, tom: dostep online, strony: dostep online), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2020.1815769 - link to the publication
  8. Label-free quantitative SWATH-MS proteomic analysis of adult myocardial slices in vitro after biomimetic electromechanical stimulation
    Authors:
    Zabielska-Kaczorowska MA, Bogucka AE, Macur K, Czaplewska P, Watson SA, Perbellini F, Terracciano CM, Smolenski RT
    Academic press:
    Sci Rep. (rok: 2022, tom: 12, strony: 16533), Wydawca: Nature Potrfolio
    Status:
    Published
    DOI:
    10.1038/s41598-022-20494-z - link to the publication
  9. Nucleotide metabolism during experimental preservation for transplantation with Transmedium Transplant Fluid (TTF) in comparison to Histidine-Tryptophan-Ketoglutarate (HTK).
    Authors:
    Zabielska-Kaczorowska MA, Smolenski RT.
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2022, tom: online ahead of print, strony: 45301), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2022.2139393 - link to the publication
  10. Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions
    Authors:
    El-Mehalmey WA, Latif N, Ibrahim AH, Haikal RR, Mierzejewska P, Smolenski RT, Yacoub MH, Alkordi MH
    Academic press:
    Biomater Sci (rok: 2021, tom: 10, strony: 1342-1351), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1bm01519b - link to the publication
  11. Statin treatment of patients with calcific aortic valve disease modulates extracellular adenosine metabolism on the cell surface of the aortic valve
    Authors:
    Barbara Kutryb-Zajac, Patrycja Jablonska, Areta Hebanowska, Romuald Lango, Jan Rogowski, Ewa M. Slominska & Ryszard T. Smolenski
    Academic press:
    Nucleosides, Nucleotides & Nucleic Acids (rok: 2020, tom: 39, strony: 1389-1399), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2020.1733603 - link to the publication
  12. Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases
    Authors:
    Barbara Kutryb-Zajac, Paulina Mierzejewska, Ewa M. Slominska and Ryszard T. Smolenski
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204652 - link to the publication

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