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Studies of interactions and dynamics of intrinsically disordered proteins in crucial biological processes - biophysical perspective including single molecule approach

2016/22/E/NZ1/00656

Keywords

Descriptors

  • NZ1_3: Biofizyka
  • NZ1_2: Biochemia
  • NZ1_5: Inżynieria genetyczna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Fizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Anna Zofia Niedźwiecka

Number of co-investigators in the project: 6

Call

SONATA BIS 6 – announced on 2016-06-15

Amount awarded
2 271 306 PLN
Project start date
2017-04-10
Project end date
2024-04-09
Project duration
84 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (6)

  1. The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor

    Authors:
    Nikola Sozańska, Barbara P. Klepka, Anna Niedzwiecka, Lilia Zhukova, Michał Dadlez, Beata Greb-Markiewicz, Andrzej Ożyhar, Aneta Tarczewska
    Academic press:
    Cell Communication and Signaling (year: 2025, volume: 1,06527777777778, pages: 46042), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-025-02154-7 – link to the publication

  2. Exploring the CNOT1(800–999) HEAT Domain and Its Interactions with Tristetraprolin (TTP) as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

    Authors:
    Maja K. Cieplak-Rotowska, Michał Dadlez, Anna Niedźwiecka
    Academic press:
    Biomolecules (year: 2025, volume: 15(3), 403, pages: 46047), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom15030403 – link to the publication

  3. Hydrodynamic Radii of Intrinsically Disordered Proteins: Fast Prediction by Minimum Dissipation Approximation and Experimental Validation

    Authors:
    Radost Waszkiewicz, Agnieszka Michas, Michał K. Białobrzewski, Barbara P. Klepka, Maja K. Cieplak-Rotowska, Zuzanna Staszałek, Bogdan Cichocki, Maciej Lisicki, Piotr Szymczak, and Anna Niedzwiecka
    Academic press:
    The Journal of Physical Chemistry Letters (year: 2024, volume: 15, pages: 5024-5033), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c00312 – link to the publication

  4. Diffusion coefficients of elastic macromolecules

    Authors:
    Bogdan Cichocki, Marcin Rubin, Anna Niedźwiecka, Piotr Szymczak
    Academic press:
    Journal of Fluid Mechanics (year: 2019, volume: 878, pages: R3), Publisher: CAMBRIDGE UNIV PRESS
    Status:
    Published
    DOI:
    10.1017/jfm.2019.652 – link to the publication

  5. Diversity of hydrodynamic radii of intrinsically disordered proteins

    Authors:
    Michał K. Białobrzewski, Barbara P. Klepka, Agnieszka Michaś, Maja K. Cieplak-Rotowska, Zuzanna Staszałek, Anna Niedźwiecka
    Academic press:
    European Biophysics Journal (year: 2023, volume: 52, pages: 607-618), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-023-01683-8 – link to the publication

  6. Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

    Authors:
    Cieplak-Rotowska Maja K., Tarnowski Krzysztof, Rubin Marcin, Fabian Marc R., Sonenberg Nahum, Dadlez Michał, Niedźwiecka Anna
    Academic press:
    Journal of The American Society for Mass Spectrometry (year: 2018, volume: 29, pages: 158-173), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13361-017-1830-9 – link to the publication

Articles in post-conference publications (13)

  1. Coral acid-rich protein-mediated emergence of calcium carbonate spherulitic structures,

    Authors:
    B. Klepka, T. Wojciechowski, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (year: 2023, pages: 81), Publisher: European Physical Society
    Date:
    conference 14-18 maja 2023
    Status:
    Published

  2. FCS and confocal studies of early stages of biomineralization steered by intrinsically disordered coral acid-rich proteins

    Authors:
    Barbara Klepka, Anna Niedźwiecka
    Conference:
    7th European Workshop on Advanced Fluorescence Methods 2022 (year: 2022, pages: 10), Publisher: LMU Munich
    Date:
    conference 5 - 9 grudnia 2022
    Status:
    Published

  3. Formation of calcium carbonate spherulites driven by coral polyanionic protein

    Authors:
    B. Klepka, T. Wojciechowski, A. Niedźwiecka
    Conference:
    Zakopane School of Physics -Breaking Frontiers: Submicron Structures in Physics and Biology (year: 2023, pages: 81), Publisher: Uniwersytet Jagielloński
    Date:
    conference 23-27 maja 2023
    Status:
    Published

  4. Expression and purification of intrinsically disordered C-terminal fragments of PARN in fusion with mCherry for FCS and SEC studies

    Authors:
    Z. Staszałek, M. K. Białobrzewski, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (year: 2023, pages: 111), Publisher: European Physical Society
    Date:
    conference 14-18 czerwca 2023
    Status:
    Published

  5. Fluorescence Correlation Spectroscopy Studies of Properties and Interactions of Intrinsically Disordered Proteins Involved in Regulation of Gene Expression

    Authors:
    K. Białobrzewski, A. M. Michaś, M. K. Cieplak-Rotowska, M. Duszka, A. Niedźwiecka
    Conference:
    18th Congress of the Polish Biophysical Society (year: 2022, pages: 10), Publisher: Polskie Towarzystwo Biofizyczne
    Date:
    conference 06-09.09.2022
    Status:
    Published

  6. Intrinsically disordered proteins that regulate fundamental biological processes – challenging targets for biophysical studies

    Authors:
    A. Niedźwiecka, M. K. Cieplak-Rotowska, M. K. Białobrzewski, B. Klepka
    Conference:
    Zakopane School of Physics -Breaking Frontiers: Submicron Structures in Physics and Biology (year: 2023, pages: 14), Publisher: Uniwersytet Jagielloński
    Date:
    conference 23-27.05.2023
    Status:
    Published

  7. Liquid-liquid phase separation of GW182 Silencing Domain

    Authors:
    M. K. Białobrzewski, Z. Staszałek, A. Michaś, A. Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 8 (year: 2023, pages: 65), Publisher: European Physical Society
    Date:
    conference 14-18 June 2023
    Status:
    Published

  8. Studies of interactions and conformational dynamics of intrinsically disordered proteins involved in miRNA-mediated gene silencing

    Authors:
    M. K. Białobrzewski, A. M. Michaś, M. K. Cieplak-Rotowska, A. Niedźwiecka
    Conference:
    Zakopane School of Physics, Breaking Frontiers: Submicron Structures in Physics and Biology (year: 2023, pages: 83), Publisher: Uniwersytet Jagielloński
    Date:
    conference 23-27.05.2023
    Status:
    Published

  9. Interplay of protein interactions involved in miRNA-mediated gene silencing, as revealed by HDX MS

    Authors:
    M. K. Cieplak-Rotowska, K. Tarnowski, M. Dadlez, M. R. Fabian, N. Sonenberg, A. Niedźwiecka
    Conference:
    19th IUPAB and 11th EBSA Congress (year: 2017, pages: S344), Publisher: European Biophysics Journal with Biophysics Letters; Springer w imieniu European Biophysics Societes' Association
    Date:
    conference 16-20 lipca 2017
    Status:
    Published
    DOI:
    link to the publication

  10. Identification of the GW182 silencing domain-binding site on CNOT1

    Authors:
    Agnieszka Stelmachowska, Maja Cieplak-Rotowska, Anna Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 7 (year: 2019, pages: 106), Publisher: European Physical Society
    Date:
    conference 15-19 maja 2019
    Status:
    Published

  11. Calcium-mediated aggregation of intrinsically disordered polyanionic proteins involved in early stages of coral biomineralization

    Authors:
    Barbara Klepka, Anna Niedźwiecka
    Conference:
    18th Congress of the Polish Biophysical Society (PTBF) (year: 2022, pages: 64), Publisher: Polskie Towarzystwo Biofizyczne
    Date:
    conference 6 – 9 września 2022
    Status:
    Published

  12. Influence of aromatic substituents at mRNA 5' cap analogues on their interactions with human eIF4E protein

    Authors:
    Michał Białobrzewski, Karolina Piecyk, Marzena Jankowska-Anyszka, Janusz Stępiński, Edward Darżynkiewicz, Anna Niedźwiecka
    Conference:
    Biomolecules and Nanostructures 7 (year: 2019, pages: 24), Publisher: European Physical Society
    Date:
    conference 15-19 maja 2019
    Status:
    Published

  13. Formation of coral acid-rich protein aggregates with calcium cations - is there a liquid-liquid phase separation out there?

    Authors:
    Barbara Klepka, Agnieszka Michaś, Anna Niedźwiecka
    Conference:
    Cellular mechanisms driven by phase separation (year: 2022, pages: 123), Publisher: EMBL/EMBO
    Date:
    conference 9 – 12 maja 2022
    Status:
    Published

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