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The role of cancer stem cells in extracellular matrix production and drug resistance in ovarian cancer

2016/22/E/NZ5/00381

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ4_4: Patofizjologia ogólna

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Radosław Januchowski

Number of co-investigators in the project: 4

Call

SONATA BIS 6 – announced on 2016-06-15

Amount awarded
1 467 000 PLN
Project start date
2017-05-18
Project end date
2022-05-17
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dyski twarde.
  2. Stanowisko komputerowe z drukarką. Cost: 24 000 PLN

Information in the final report

Publication in academic press/journals (12)

  1. The significance of interferon gamma inducible protein 16 (IFI16) expression in drug resistant ovarian cancer cell lines

    Authors:
    Borucka Justyna, Sterzyńska Karolina, Kaźmierczak Dominika, Świerczewska Monika, Nowacka Marta, Wojtowicz Karolina, Klejewski Andrzej, Nowicki Michał, Zabel Maciej, Ramlau Rodryg, Januchowski Radosław
    Academic press:
    Biomedicine & Pharmacotherapy (year: 2022, volume: 150, pages: E113036, 13 stron), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.3390/ijms23105846 – link to the publication

  2. The profile of microRNA expression and potential role in the regulation of drug-resistant genes in doxorubicin and topotecan resistant ovarian cancer cell lines.

    Authors:
    Stasiak Piotr, Kaźmierczak Dominika, Jopek Karol, Nowicki Michał, Ruciński Marcin, Januchowski Radosław
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: E5846, 25 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105846 – link to the publication

  3. New and Old Genes Associated with Primary and Established Responses to Cisplatin and Topotecan Treatment in Ovarian Cancer Cell Lines

    Authors:
    Monika Świerczewska, Andrzej Klejewski, Karolina Wojtowicz , Maciej Brązert , Dariusz Iżycki, Michał Nowicki , Maciej Zabel and Radosław Januchowski
    Academic press:
    Molecues (year: 2017, volume: 22, pages: E1717 - 15 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22101717 – link to the publication

  4. Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development.

    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Nowacka M, Kaźmierczak D, Andrzejewska M, Rusek D, Brązert M, Brązert J, Nowicki M, Januchowski R.
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20(1), pages: E54, 21 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20010054. – link to the publication

  5. The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines.

    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Andrzejewska M, Rusek D, Sobkowski M, Kędzia W, Brązert J, Nowicki M, Januchowski R
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: E2901, 17 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19102901 – link to the publication

  6. Role of miRNA in ovarian cancer diagnosis, prognosis and development of drug resistance

    Authors:
    Kaźmierczak D, Sterzyńska K, Januchowski R
    Academic press:
    Postępy Biologii Komórki (year: 2021, volume: 48, pages: 271-282), Publisher: FUNDACJA BIOLOGII KOMÓRKI I BIOLOGII MOLEKULARNEJ
    Status:
    Published

  7. Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines.

    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Nowicki M, Brązert J, Januchowski R
    Academic press:
    Journal of Cancer (year: 2018, volume: 9, pages: 4413-4421), Publisher: IVYSPPING
    Status:
    Published
    DOI:
    10.7150/jca.27342 – link to the publication

  8. Drug Resistance Evaluation in Novel 3D In Vitro Model

    Authors:
    Marta Nowacka, Karolina Sterzynska , Malgorzata Andrzejewska , Michal Nowicki and Radoslaw Januchowski
    Academic press:
    Biomedicine & Pharmacotherapy (year: 2021, volume: 138, pages: E111536, 15 stron), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.111536 – link to the publication

  9. Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines

    Authors:
    Sterzyńska K, Kaźmierczak D, Klejewski A, Świerczewska M, Wojtowicz K, Nowacka M, Brązert J, Nowicki M, Januchowski R
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20(16), pages: E3927, 15 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20163927. – link to the publication

  10. The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

    Authors:
    Dominika Kazmierczak, Karol Jopek, Karolina Sterzynska, Michal Nowicki, Marcin Rucinski and Radoslaw Januchowski
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: E526, 21 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010526 – link to the publication

  11. Effect of ALDH1A1 Gene Knockout on Drug Resistance in Paclitaxel and Topotecan Resistant Human Ovarian Cancer Cell Lines in 2D and 3D Model

    Authors:
    Marta Nowacka, Barbara Ginter-Matuszewska, Monika Swierczewska, Karolina Sterzyńska, Michał Nowicki and Radosław Januchowski
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: E3036, 23 strony), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063036 – link to the publication

  12. The significance of microRNA genes expression in regulation of extracellular matrix and others drug resistant genes in drug resistant ovarian cancer cell lines

    Authors:
    Dominika Kaźmierczak, Karol Jopek, Karolina Sterzyńska, Barbara Ginter-Matuszewska, Michał Nowicki, Marcin Ruciński, Radosław Januchowski
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 9;21(7), pages: 2619), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072619 – link to the publication

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