Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Unknown areas of activity of human ribonuclease Dicer

2016/22/E/NZ1/00422

Keywords:

ribonuclease Dicer microRNA biogenesis short regulatory RNAs

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ2_7: Bioinformatics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Kurzyńska-Kokorniak 

Number of co-investigators in the project: 5

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 959 600 PLN

Project start date (Y-m-d): 2017-05-08

Project end date (Y-m-d): 2023-05-07

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna z pionowym przepływem powietrza, klasa bezpieczeństwa II (35 000 PLN)
  2. Aspirator.
  3. Termocykler (25 000 PLN)
  4. Licencja oprogramowania DNA Dynamo Software.
  5. Zestaw komputerowy wraz z oprogramowaniem (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Genetic Insight into the Domain Structure and Functions of Dicer-Type Ribonucleases
    Authors:
    Ciechanowska Kinga, Pokornowska Maria, Kurzyńska-Kokorniak Anna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(2), strony: 616), Wydawca: MDPI, St. Alban-Anlage 66, 4052 Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms22020616 - link to the publication
  2. Characteristics of Transfer RNA-Derived Fragments Expressed during Human Renal Cell Development: The Role of Dicer in tRF Biogenesise Role of Dicer in tRF Biogenesis
    Authors:
    Kazimierczyk Marek, Wojnicka Marta, Biała Ewa, Żydowicz-Machtel Paulina, Imiołczyk Barbara, Ostrowski Tomasz, Kurzyńska-Kokorniak Anna, Wrzesinski Jan
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(7), strony: nr artykułu: 3644), Wydawca: MDPI, St. Alban-Anlage 66, 4052 Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms23073644 - link to the publication
  3. Human ribonuclease Dicer – structure and functions
    Authors:
    Koralewska N, Ciechanowska K, Pokornowska M, Figlerowicz M, Kurzyńska-Kokorniak A.
    Academic press:
    Postępy Biochemii (rok: 2019, tom: 65(3), strony: 173-182), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2019_267 - link to the publication
  4. The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer
    Authors:
    Szczepańska Agnieszka, Wojnicka Marta, Kurzyńska-Kokorniak Anna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(16), strony: 8690), Wydawca: MDPI, St. Alban-Anlage 66, 4052 Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms22168690 - link to the publication
  5. RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
    Authors:
    Koralewska Natalia, Szczepańska Agnieszka, Ciechanowska Kinga, Wojnicka Marta, Pokornowska Maria, Milewski Marek, Gudanis Dorota, Baranowski Daniel, Nithin Chandran, Bujnicki Janusz, Gdaniec Zofia, Figlerowicz Marek, Kurzyńska-Kokorniak Anna
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78(7), strony: 3709-3724), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s00018-021-03795-w - link to the publication
  6. The RNA-RNA base pairing potential of human Dicer and Ago2 proteins
    Authors:
    Pokornowska M, Milewski MC, Ciechanowska K, Szczepańska A, Wojnicka M, Radogostowicz Z, Figlerowicz M, Kurzynska-Kokorniak A.
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2020, tom: 77 (16), strony: 3231-3244), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03344-6 - link to the publication
  7. Unknown Areas of Activity of Human Ribonuclease Dicer: A Putative Deoxyribonuclease Activity
    Authors:
    Wojnicka M, Szczepanska A, Kurzynska-Kokorniak A.
    Academic press:
    Molecules (rok: 2020, tom: 25(6), strony: 1414), Wydawca: MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
    Status:
    Published
    DOI:
    10.3390/molecules25061414 - link to the publication

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