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Genetic features of Reed-Sternberg cells and their interplay with macrophages in classical Hodgkin lymphoma: identification of drug resistance and disease relapse mechanisms.

2016/22/M/NZ5/00668

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_5: Diagnostyka chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Hematologii i Transfuzjologii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Przemysław Juszczyński

Number of co-investigators in the project: 9

Call

HARMONIA 8 – announced on 2016-06-15

Amount awarded
1 497 441 PLN
Project start date
2017-06-21
Project end date
2023-04-20
Project duration
70 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

  1. PIM Kinases Promote Survival and Immune Escape in Primary Mediastinal Large B-Cell Lymphoma through Modulation of JAK-STAT and NF-κB Activity

    Authors:
    Szydłowski M, Dębek S, Prochorec-Sobieszek M, Szołkowska M, Tomirotti AM, Juszczyński P, Szumera-Ciećkiewicz A.
    Academic press:
    Am J Pathol. (year: 2020, volume: 191, pages: 567-574), Publisher: American Society for Investigative Pathology
    Status:
    Published
    DOI:
    10.1016/j.ajpath.2020.12.001 – link to the publication

  2. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

    Authors:
    Maciej Szydłowski, Filip Garbicz, Ewa Jabłońska , Patryk Górniak, Dorota Komar, Beata Pyrzyńska, Kamil Bojarczuk, Monika Prochorec-Sobieszek , Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Gołas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Białopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Puła, Michał Pawlak, Dominika Nowis, Jakub Golab, Andrea M Tomirotti, Krzysztof Brzózka, Mariana Pacheco-Blanco, Kristyna Kupcova, Michael R Green, Ondrej Havranek, Bjoern Chapuy, Przemysław Juszczyński
    Academic press:
    Cancer Research (year: 2021, volume: 81, pages: 6029-6043), Publisher: AACR
    Status:
    Published
    DOI:
    10.1158/0008-5472.CAN-21-1023 – link to the publication

  3. PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma

    Authors:
    Maciej Szydłowski, Ewa Kurtz, Filip Garbicz, Julia Maroszek, Michał Pawlak, Natalia Ochocka, Marcin Tabaka, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Patryk Górniak, Olga Szymańska-Giemza, Grzegorz Rymkiewicz, Agnieszka Kołkowska-Leśniak, Wojciech Kukwa, Ewa Paszkiewicz-Kozik, Justyna Totoń-Żurańska, Sylwia Radomska, Zofia Pilch, Dominika Nowis, Jakub Golab, Michał Kurlapski, Jan Maciej Zaucha, Alicja Braczko, Marcin Kaszkowiak, Paweł Wołkow, Katarzyna Wiktorska, John Brognard, Sabina Lichołai, Ewa Lech-Marańda, Przemysław Juszczyński
    Status:
    Accepted for publication

Articles in post-conference publications (2)

  1. Hodgkin Lymphoma Reed-Sternberg Cells Induce Immunosuppressive and Pro-Angiogenic Phenotype of Tumor-Associated Macrophages in a Paracrine Manner

    Authors:
    Maciej Szydlowski, Michał Pawlak, Filip Garbicz, Patryk Górniak, Justyna Żurańska, Magdalena Król, Bartłomiej Taciak, Maciej Białasek, Anna Szumera-Ciećkiewicz, Kamil Sokół, Monika Stańczak, Daria Owczarek, Monika Prochorec-Sobieszek, Anna Polak, Emilia Bialopiotrowicz, Michał Kurlapski, Jan Zaucha, Paweł Wołkow, Przemyslaw Juszczynski
    Conference:
    All-Virtual 62nd ASH Annual Meeting & Exposition (year: 2020, pages: 30-30), Publisher: American Society of Hematology
    Date:
    conference 2020-12
    Status:
    Published
    DOI:
    link to the publication

  2. Inhibition of PIM Kinases in Diffuse Large B-Cell Lymphoma Cells Targets MYC-Dependent Transcriptional Program, Increases CD20 Expression and Augments the Efficacy of Anti-CD20 Antibodies

    Authors:
    Maciej Szydlowski, Filip Garbicz, Ewa Jabłońska, Patryk Górniak, Beata Pyrzynska, Kamil Bojarczuk, Dorota Komar, Monika Prochorec-Sobieszek, Anna Szumera-Ciećkiewicz, Grzegorz Rymkiewicz, Magdalena Cybulska, Małgorzata Statkiewicz, Marta Gajewska, Michał Mikula, Aniela Golas, Joanna Domagała, Magdalena Winiarska, Agnieszka Graczyk-Jarzynka, Emilia Bialopiotrowicz, Anna Polak, Joanna Barankiewicz, Bartosz Pula, Michael R Green, Dominika Nowis, Jakub Golab, Andrea Massimiliano Tomirotti, Krzysztof Brzózka, Mariana Pacheco-Blanco, Kristyna Kupcova, Ondrej Havranek, Bjoern Chapuy, Przemyslaw Juszczynski.
    Conference:
    All-Virtual 62nd ASH Annual Meeting & Exposition (year: 2020, pages: Blood (2020) 136 (Supplement 1): 33–34.), Publisher: American Society of Hematology
    Date:
    conference 2020-12
    Status:
    Published
    DOI:
    link to the publication

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