Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Senescence or apoptosis: role of miR-34a in endothelial cells

2016/22/E/NZ3/00405

Keywords:

microRNA miR-34a senescence apoptosis Nrf2 endothelium autophagy DNA damage mitoptosis metabolism

Descriptors:

  • NZ3_4:
  • NZ3_7:
  • NZ3_3:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Grochot-Przęczek 

Number of co-investigators in the project: 4

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 2 467 000 PLN

Project start date (Y-m-d): 2017-04-11

Project end date (Y-m-d): 2023-04-10

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Nrf2 Sequesters Keap1 Preventing Podosome Disassembly: A Quintessential Duet Moonlights in Endothelium
    Authors:
    Damian Kloska, Aleksandra Kopacz, Dominik Cysewski, Martin Aepfelbacher, Jozef Dulak, Alicja Jozkowicz, Anna Grochot-Przeczek
    Academic press:
    Antioxidants & Redox Signaling (rok: 2019, tom: 30, strony: 1790-1730), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/ars.2018.7505 - link to the publication
  2. Beyond repression of Nrf2: an update on Keap1
    Authors:
    Aleksandra Kopacz, Damian Kloska, Henry Jay Forman, Alicja Jozkowicz, Anna Grochot-Przeczek
    Academic press:
    Free Radical Biology and Medicine (rok: 2020, tom: 157, strony: 63-74), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.03.023 - link to the publication
  3. Overlooked and valuable facts to know in the NRF2/KEAP1 field
    Authors:
    Aleksandra Kopacz, Ana I. Rojo, Chinmai Patibandla, Diego Lastra-Martínez, Aleksandra Piechota-Polanczyk, Damian Kloska, Alicja Jozkowicz, Calum Sutherland, Antonio Cuadrado, Anna Grochot-Przeczek
    Academic press:
    Free Radical Biology and Medicine (rok: 2022, tom: 192, strony: 37-49), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2022.08.044 - link to the publication
  4. Keap1 governs ageing-induced protein aggregation in endothelial cells
    Authors:
    Aleksandra Kopacz, Damian Kloska, Marta Targosz-Korecka, Bartłomiej Zapotoczny, Dominik Cysewski, Nicolas Personnic, Ewa Werner, Karolina Hajduk, Alicja Jozkowicz, Anna Grochot-Przeczek
    Academic press:
    Redox Biology (rok: 2020, tom: 34, strony: 101572), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2020.101572 - link to the publication
  5. Nrf2 in aging – Focus on the cardiovascular system
    Authors:
    Damian Kloska, Aleksandra Kopacz, Aleksandra Piechota-Polanczyk, Witold N. Nowak, Jozef Dulak, Alicja Jozkowicz, Anna Grochot-Przeczek
    Academic press:
    Vascular Pharmacology (rok: 2019, tom: 112, strony: 42-53), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2018.08.009 - link to the publication
  6. Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.
    Authors:
    Kopacz A, Klóska D, Proniewski B, Cysewski D, Personnic N, Piechota-Polańczyk A, Kaczara P, Zakrzewska A, Forman HJ, Dulak J, Józkowicz A, Grochot-Przęczek A.
    Academic press:
    Redox Biology (rok: 2020, tom: 28, strony: 101304), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2019.101304 - link to the publication
  7. Simvastatin Attenuates Abdominal Aortic Aneurysm Formation Favoured by Lack of Nrf2 Transcriptional Activity
    Authors:
    Aleksandra Kopacz, Ewa Werner, Anna Grochot-Przęczek, Damian Klóska, Karolina Hajduk, Christoph Neumayer, Alicja Józkowicz, Aleksandra Piechota-Polanczyk
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2020, tom: 2020, strony: -), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/6340190 - link to the publication
  8. Endothelial miR-34a deletion guards against aneurysm development despite endothelial dysfunction
    Authors:
    Aleksandra Kopacz; Damian Kloska; Anna Bar; Marta Targosz-Korecka; Dominik Cysewski; Kamil Awsiuk; Aleksandra Piechota-Polanczyk;Milena Cichon; Stefan Chlopicki; Alicja Jozkowicz; Anna Grochot-Przeczek
    Status:
    Accepted for publication

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