Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Neuromedin U, new potential regulator of colorectal cancer metastasis mechanisms.

2016/22/E/NZ3/00341

Keywords:

colorectal cancer metastasis neuromedin U

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Patrycja Przygodzka 

Number of co-investigators in the project: 4

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 315 716 PLN

Project start date (Y-m-d): 2017-05-05

Project end date (Y-m-d): 2022-05-04

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kołyska laboratoryjna. (5 000 PLN)
  2. Zestaw komputerowy z systemem Windows Professional, oprogramowaniem Microsoft Office (4 500 PLN)
  3. Aparat do prowadzenia reakcji PCR w czasie rzeczywistym z komputerem sterującym pracą urządzenia oraz oprogramowaniem do analizy danych. (180 000 PLN)
  4. Termomikser z wymiennymi blokami grzejnymi.
  5. Szybkoobrotowa wirówka laboratoryjna.

Information in the final report

  • Publication in academic press/journals (5)
  1. Regulation of miRNAs by Snail during epithelial-to-mesenchymal transition in HT29 colon cancer cells.
    Authors:
    Patrycja Przygodzka , Izabela Papiewska-Pająk, Helena Bogusz-Koziarska, Ewelina Sochacka, Joanna Boncela & M. Anna Kowalska
    Academic press:
    Scientific reports (rok: 2019, tom: 9, strony: 2165), Wydawca: Nature research
    Status:
    Published
    DOI:
    10.1038/s41598-019-39200-7 - link to the publication
  2. Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor.
    Authors:
    Przygodzka Patrycja, Sochacka Ewelina, Soboska Kamila, Pacholczyk Marcin, Papiewska-Pająk Izabela, Przygodzki Tomasz, Płociński Przemysław, Ballet Steven, De Prins Ann, Boncela Joanna
    Academic press:
    Journal of Experimental and Clinical Cancer Research (rok: 2021, tom: 40: 283, strony: -), Wydawca: BioMed Central Ltd. Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13046-021-02073-8 - link to the publication
  3. Snail Overexpression Alters the microRNA Content of Extracellular Vesicles Released from HT29 Colorectal Cancer Cells and Activates Pro-Inflammatory State In Vivo.
    Authors:
    Izabela Papiewska-Pająk, Patrycja Przygodzka, Damian Krzyżanowski, Kamila Soboska, Izabela Szulc-Kiełbik, Olga Stasikowska-Kanicka, Joanna Boncela, Małgorzata Wągrowska-Danilewicz, M. Anna Kowalska
    Academic press:
    Cancers (rok: 2021, tom: 13 (2), 172, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13020172 - link to the publication
  4. Neuromedin U: A Small Peptide in the Big World of Cancer
    Authors:
    Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Joanna Boncela
    Academic press:
    Cancers (rok: 2019, tom: 11 (9), strony: 1312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11091312 - link to the publication
  5. Neuromedin U secreted by colorectal cancer cells promotes a tumour-supporting microenvironment.
    Authors:
    Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Marcin Pacholczyk, Marcin Braun, Hassan Kassassir, Izabela Papiewska-Pająk, Michał Kiełbik, Joanna Boncela
    Academic press:
    Journal of Experimental & Clinical Cancer Research (tom: x, strony: x), Wydawca: x
    Status:
    Submitted