Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Rescue from bone loss, diminished mineral density and strength in mice after treatment with steroid and nonsteroid anti-inflammatory drugs by injection of exosomes with agomir miRNA

2016/21/B/NZ7/02748

Keywords:

diclofenac methylprednisolone miRNA bone strength mineralization non-steroid anti-inflammatory drug glucocorticoid

Descriptors:

  • NZ7_7: Rehabilitation
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Głowacki 

Number of co-investigators in the project: 9

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 620 750 PLN

Project start date (Y-m-d): 2017-03-03

Project end date (Y-m-d): 2022-03-02

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Bieżnia laboratoryjna dla myszy NG firmy Ugo Basile, numer katalogowy: 47303.

Information in the final report

  • Publication in academic press/journals (6)
  1. Gene Expression in MC3T3-E1 Cells Treated with Diclofenac and Methylprednisolone
    Authors:
    Tomasz P. Lehmann, Ewa Iwańczyk-Skalska, Jerzy Harasymczuk , Paweł P. Jagodziński, Maciej Głowacki
    Academic press:
    Genes (rok: 2023, tom: 14, strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes14010184 - link to the publication
  2. Mechanical properties of the mouse femur after treatment with diclofenac and running exercises
    Authors:
    A. Trzaskowska, S. Mielcarek, T. Lehmann, E. Pruszyńska-Oszmałek, P. Kołodziejski, M. Głowacki
    Academic press:
    Acta Bioeng Biomech (rok: 2022, tom: 24, strony: 129-139), Wydawca: Faculty of Mechanical Engineering Wroclaw University of Technology
    Status:
    Published
    DOI:
    10.37190/ABB-02061-2022-03 - link to the publication
  3. Recovery from bone loss, diminished mineral density and strength in mice after treatment with steroidal and nonsteroidal anti-inflammatory drugs by injection of exosomes enriched with agomir miRNAs
    Authors:
    Tomasz P. Lehmann, Ewa Pruszyńska-Oszmałek, Paweł Kołodziejski, Magdalena Wojtków, Celina Pezowicz, Mirosław Szybowicz, Paweł Jagodzinski, Marek Nowicki, Aleksandra Trzaskowska, Sławomir Mielcarek, Maciej Głowacki
    Academic press:
    Journal of Medicinal Science (rok: 2019, tom: 88, strony: 261-266), Wydawca: Poznan University of Medical Sciences, Poland
    Status:
    Published
    DOI:
    10.20883/medical.379 - link to the publication
  4. Trabecular bone remodelling in the femur of C57BL/6J mice treated with diclofenac in combination with treadmill exercise
    Authors:
    Tomasz P. Lehmann, Magdalena Wojtków, Ewa Pruszyńska-Oszmałek, Paweł Kołodziejski, Celina Pezowicz, Aleksandra Trzaskowska, Sławomir Mielcarek, Mirosław Szybowicz, Ariadna B. Nowicka, Marek Nowicki, Ewa Misterska, Ewa Iwańczyk-Sklaska, Paweł Jagodziński, Maciej Głowacki
    Academic press:
    Acta of Bioengineering and Biomechanics (rok: 2021, tom: 23, strony: 45362), Wydawca: Faculty of Mechanical Engineering Wroclaw University of Technology
    Status:
    Published
    DOI:
    10.37190/ABB-01851-2021-01 - link to the publication
  5. Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo
    Authors:
    Natalia Leciejewska, Ewa Pruszynska-Oszmałek, Karolina Mielnik, Maciej Głowacki, Tomasz P. Lehmann, Maciej Sassek, Bartosz Gaweda , Dawid Szczepankiewicz, Krzysztof W. Nowak and Paweł A. Kołodziejski
    Academic press:
    Genes (rok: 2022, tom: 13, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13010081 - link to the publication
  6. The regulation of collagen processing by miRNAs in disease and possible implications for bone turnover.
    Authors:
    Lehmann Tomasz P., Guderska Urszula, Kałek Klaudia, Marzec Maria, Urbanek Agnieszka, Czernikiewicz Alicja, Sąsiadek Maria, Karpiński Paweł, Pławski Andrzej, Głowacki Maciej, Jagodziński Paweł P.
    Academic press:
    Int. J. Mol. Sci. (rok: 2022, tom: 23, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010091 - link to the publication

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