Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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System engineering approach to modeling, analysis and prediction of outcome of combined anticancer therapies

2016/21/B/ST7/02241

Keywords:

Hybrid models clinical data analysis combined anticancer therapy evolutionary games

Descriptors:

  • ST7_4: Micro- and nanosystems engineering
  • ST7_3: Simulation engineering and modelling
  • ST7_11: Electronic, optoelectronic and photonic components and systems for applications (e.g. in biomedical engineering)

Panel:

ST7 - Systems and communication engineering: electronics, communication, optoelectronics

Host institution :

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Świerniak 

Number of co-investigators in the project: 8

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 800 240 PLN

Project start date (Y-m-d): 2017-02-13

Project end date (Y-m-d): 2020-08-12

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  • Articles in post-conference publications (8)
  • Book publications / chapters in book publications (4)
  1. Computational determination of the optimal dose of the cis-platinum to maximize the life time of patients diagnosed with cancer
    Authors:
    E. Kozłowska, K. Puszynski
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2019, tom: 47/2 (29/63), strony: 187-196), Wydawca: Polskie Towarzystwo matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v47i2.6485 - link to the publication
  2. Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level
    Authors:
    M. Kardynska, A. Paszek, J. Smieja, D. Spiller, W. Widlak, M. White, P. Paszek, M. Kimmel
    Academic press:
    PLOS Computational Biology (rok: 2018, tom: 14, strony: e1006130), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1006130 - link to the publication
  3. Spatiotemporal sensitivity of systems modeled by cellular automata,
    Authors:
    Krzysztof Fujarewicz, Krzysztof łakomiec
    Academic press:
    Mathematical Methods in Applied Sciences (rok: 2018, tom: 41, strony: 8897-8905), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/mma.5358 - link to the publication
  4. Circuits regulating superoxide and nitric oxide production and neutralization in different cell types: expression of participating genes and changes induced by ionizing radiation
    Authors:
    P. Bil, S. Ciesielska, R. Jaksik, J. Rzeszowska-Wolny
    Academic press:
    Antioxidants (rok: 2020, tom: 9, strony: 701 (1-14)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9080701 - link to the publication
  5. Virtual clinical trials identify effective combination therapies in ovarian cancer
    Authors:
    Emilia Kozłowska, Tuulia Vallius, Johanna Hynninen, Skari Hietanen, Anniina Farkkila, Sampsa Hautaniemi
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: art.n. 18678), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-55068-z - link to the publication
  6. Time-dependent synergy for multi-agent anticancer therapy
    Authors:
    K. Fujarewicz, K. Lakomiec
    Academic press:
    BioRxiv (rok: 2020, tom: 44105, strony: BIORXIV/2020/332031 (1-11)), Wydawca: BioRxiv Team
    Status:
    Published
    DOI:
    10.08.332031 - link to the publication
  7. Heavy-tailed distributions in branching process models of secondary cancerous tumors
    Authors:
    P. A. Ernst, M. Kimmel, M. Kurpas, Q. Zhou
    Academic press:
    Journal of Applied Probability (rok: 2018, tom: 50, strony: 99-114), Wydawca: Applied Probability Trust
    Status:
    Published
    DOI:
    10.1017/apr.2018.73 - link to the publication
  8. Mathematical modelling reveals unexpected inheritance and variability patterns of cell cycle parameters in mammalian cells,
    Authors:
    M. Mura, C. Feillet, R. Bertolusso, F. Delaunay, M. Kimmel
    Academic press:
    PLOS Computational Biology (rok: 2019, tom: 15, strony: art. n. e10007054), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pchi.1007054 - link to the publication
  9. Optimal control in a model of chemotherapy-induced radiosensilisation
    Authors:
    Piotr Bajger, Krzysztof Fujarewicz, Andrzej Swierniak
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2019, tom: 47/1 (28/63), strony: 81-91), Wydawca: Polskie Towarzystwo Matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v47i1.6480 - link to the publication
  10. Prediction of lung cancer patients' response to combined chemo-radiotherapy using a personalised hybrid model,
    Authors:
    Sebastian Wolkowicz, Krzysztof Fujarewicz, Monika Kurpas, Krzysztof Lakomiec, Jaroslaw Smieja, Rafał Suwinski, Andrzej Swierniak
    Academic press:
    Mathematica Applicanda (Matematyka Stosowana) (rok: 2019, tom: 47/2 (29/63), strony: 219-228), Wydawca: Polskie Towarzystwo Matematyczne
    Status:
    Published
    DOI:
    10.14708/ma.v47i2.6486 - link to the publication
  11. Application of sensitivity analysis to discover potential molecular drug targets
    Authors:
    M. Kardynska, J. Smieja, P. Paszek, K. Puszynski
    Academic press:
    European Journal of Pharmacology (rok: 2020, ), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  12. Anticancer activity of functional polysuccinates with N-aceryl-cysteine in side chains
    Authors:
    M. Mrówka, K. jaszcz, M. Skonieczna
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 885, strony: nr. 173501), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173501 - link to the publication
  13. Heat shock response regulates stimulus specificity and sensitivity of the proinflammatory NF-kB signalling.
    Authors:
    A. Paszek, M. Kardynska, J. Bagnall, J. Smieja, D.G. Spiller, P. Widlak, M. Kimmel. W. Widlak, P. Paszek
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18/1, strony: Article Numeber 77), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-020-00583-0 - link to the publication
  14. LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies
    Authors:
    M. Hashemi, S. Sarabandi, S. Karami, J. Smieja, A. Moazeni-Roodi, S. Ghavami, M. J. Los
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: 24, strony: 1160-1168), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.14836 - link to the publication
  15. Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum based doublet
    Authors:
    E. Kozlowska, R. Suwinski, M. Giglok, A. swierniak, M. Kimmel
    Academic press:
    PLOS Computational Biology (rok: 2020, tom: 16, strony: 16(10): e1008234), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1008234 - link to the publication
  16. THE ROLE OF INTERVENTIONS IN THE CANCER EVOLUTION - AN EVOLUTIONARY GAMES APPROACH
    Authors:
    A. Swierniak, M. Krzeslak, D.Borys, M. Kimmel
    Academic press:
    Mathematical Biosciences and Engineering (rok: 2018, tom: 16, strony: 265-291), Wydawca: AIMS
    Status:
    Published
    DOI:
    10.3934/mbe.2019014 - link to the publication
  1. Control time delay in optimal control problems arising in combined anticancer therapies
    Authors:
    Andrzej Swierniak, Helmut Maurer
    Conference:
    14th Vienese Conference Optimal Control and Dynamic Games, (rok: 2018, ), Wydawca: University of Vien
    Data:
    konferencja 3.07 - 6.07
    Status:
    Published
  2. Modeling and optimization of combined chemo-radiotherapy
    Authors:
    Andrzej Swierniak, Jaroslaw Smieja, Krzysztof Fujarewicz, Rafal Suwinski
    Conference:
    The 2019 European Simulation and Modelling Conference , Modelling and Simulation'2019, ESM'2019 (rok: 2019, ), Wydawca: Universitad de Illes Balears, Spain
    Data:
    konferencja 43766
    Status:
    Published
  3. Effects of pharmacokinetics and DNA repair on the structure of optimal controls insimple model of radio-chemotherapy
    Authors:
    Piotr Bajger, Krzysztof Fujarewicz, Andrzej Świerniak
    Conference:
    International Conference on Models and Methods in Automation and Robotics, Międzyzdroje (rok: 2018, ), Wydawca: IEEE
    Data:
    konferencja 43338
    Status:
    Published
  4. 3D spatial dependencies study in the hawk and dove model
    Authors:
    A. Swierniak, M. Bonk, D. Borys
    Conference:
    13th International Conference on Biomedical Engineering Systems and Technologies and 11th International Conference on Bioinformatics Models, Methods and Algorithms - Bioinformatics 2020 (rok: 2020, ), Wydawca: BIOSTEC
    Data:
    konferencja 43884
    Status:
    Published
  5. Games with resources and their use in modeling control processes in heterogenous populations
    Authors:
    Andrzej Swierniak, Michal Krzeslak, Damian Borys
    Conference:
    23rd International Conference on Methods and Models in Automation and Robotics, Międzyzdroje (rok: 2019, ), Wydawca: IEEE
    Data:
    konferencja 43703
    Status:
    Published
  6. Modeling evolutionary effects of anticancer therapies by spatial games with resources
    Authors:
    A. Swierniak, D. Borys
    Conference:
    21st IFAC World Congress in Berlin, (1st Virtual IFAC World Congress) (rok: 2020, ), Wydawca: IFAC
    Data:
    konferencja 44036
    Status:
    Published
  7. Structural sensitivity of control models arising in combined chemo-radiotherapy
    Authors:
    Marzena Dolbniak, Jaroslaw Smieja, Andrzej Swierniak
    Conference:
    International Conference on Models and Methods in Automation and Robotics, Międzyzdroje (rok: 2018, ), Wydawca: IEEE
    Data:
    konferencja 43338
    Status:
    Published
  8. Combined radio-chemo-therapy as a control problem: optimization of protocols vs. real therapy schedules,
    Authors:
    Andrzej Swierniak, Piotr Bajger, Rafał Suwiński, Jarosław Śmieja
    Conference:
    EuroSciCon Conference on Robotics, Automation and Data Analytics (rok: 2019, ), Wydawca: EuroSciCon
    Data:
    konferencja 43564
    Status:
    Published
  1. Games with resources and their use in modeling effects of anticancer treatment
    Authors:
    Andrzej Świerniak, Michał Krześlak, Damian Borys
    Book:
    Information Technology in Biomedicine, Proc. 6th Intern. Conf. ITIB'2018 (rok: 2018, tom: 762, strony: 290-303), Wydawca: Springer Nature
    Status:
    Published
  2. Sensitivity Analysis of Biomedical Models Using Green's Function
    Authors:
    Łakomiec K., Kurasz K., Fujarewicz K.
    Book:
    Information Technology in Biomedicine. ITIB 2018. Advances in Intelligent Systems and Computing, (rok: 2018, tom: 762, strony: 481-492), Wydawca: Springer Nature
    Status:
    Published
  3. Modeling and optimization of radio-chemotherapy
    Authors:
    Andrzej Swierniak, Jaroslaw Smieja, Marzena Mura, Piotr Bajgier
    Book:
    Advances in Intelligent Systems and Computing, (Proc. of 21 Polish Conference on Biocybernetics and Biomedical Engineering) (rok: 2020, tom: 1033, strony: 223-234), Wydawca: Springer
    Status:
    Published
  4. Towards personalized radio-chemotherapy - learning from clinical data vs. model optimization
    Authors:
    A. Swierniak, J. Smieja, K. Fujarewicz, R. Suwinski
    Book:
    Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (rok: 2020, tom: LNAI 12033, strony: 371-379), Wydawca: Springer
    Status:
    Published

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