Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Functional characterization of adipose-derived mesenchymal stem cells of patients suffering from rheumatic diseases in an aspect of their therapeutic application

2016/21/B/NZ5/00500

Keywords:

mesenchymal stem cells adipose tissue systemic lupus erythematosus systemic sclerosis ankylosing spondylitis

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Kontny 

Number of co-investigators in the project: 10

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 140 000 PLN

Project start date (Y-m-d): 2017-01-18

Project end date (Y-m-d): 2022-01-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kamera do mikroskopu wraz z oprogramownaiem do wizualizacji (20 000 PLN)
  2. Modernizacja cytometru przepływowego Aria I do Arii II (280 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (3)
  1. Inhibition of allogeneic and autologous T cell proliferation by adipose-derived mesenchymal stem cells of ankylosing spondylitis patients.
    Authors:
    Ewa Kuca-Warnawin, Magdalena Plebańczyk, Krzysztof Bonek, Ewa Kontny
    Academic press:
    Stem Cells International (rok: 2021, tom: 2021, strony: article ID 6637328, 17 stron), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6637328 - link to the publication
  2. Modulatory impact of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients on T helper cell differentiation.
    Authors:
    Ewa Kuca-Warnawin, Iwona Janicka, Krzysztof Bonek, Ewa Kontny
    Academic press:
    Cells (rok: 2021, tom: 10, strony: article ID 280, 15 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10020280 - link to the publication
  3. Modulation of T-cell activation markers expression by the adipose tissue-derived mesenchymal stem cells of patients with rheumatic diseases.
    Authors:
    Ewa Kuca-Warnawin, Iwona Janicka, Piotr Szczęsny, Marzena Olesińska, Krzysztof Bonek, Piotr Głuszko, Ewa Kontny
    Academic press:
    Cell Transplantation (rok: 2020, tom: 29, strony: 45304), Wydawca: SAGE Publication LTD
    Status:
    Published
    DOI:
    10.1177/0963689720945682 - link to the publication
  4. The phenotype and secretory activity of adipose-derived mesenchymal stem cells (ASCs) of patients with rheumatic disease.
    Authors:
    Ewa Kuca-Warnawin, Urszula Skalska, Iwona Janicka, Urszula Musiałowicz, Krzysztof Bonek, Piotr Głuszko, Piotr Szczęsny, Marzena Olesińska, Ewa Kontny
    Academic press:
    Cells (rok: 2019, tom: 8 (12), strony: pi:E1659), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8121659 - link to the publication
  5. Direct anti-proliferative effect of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients on allogeneic CD4+ cells.
    Authors:
    Ewa Kuca-Warnawin, Magdalena Plebańczyk, Krzysztof Bonek, Ewa Kontny
    Academic press:
    Reumatologia (rok: 2021, tom: 59, strony: 45648), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/reum.2021.103940 - link to the publication
  6. Impact and possible mechanism(s) of adipose tissue-derived mesenchymal stem cells on T-cell proliferation in patients with rheumatic disease.
    Authors:
    Ewa Kuca-Warnawin, Marzena Olesińska, Piotr Szczęsny, Ewa Kontny
    Academic press:
    Frontiers in Physiology (rok: 2022, tom: 12, strony: Article 749481, 1-16), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphys.2021.749481 - link to the publication
  7. Impact of adipose-derived mesenchymal stem cells (ASCs) of rheumatic disease patients on T helper cell differentiation.
    Authors:
    Ewa Kuca-Warnawin, Magdalena Plebańczyk, Marzena Ciechomska, Marzena Olesińska, Piotr Szczęsny, Ewa Kontny
    Academic press:
    International Journal of Molecular Sciences , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Basic characteristics of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients.
    Authors:
    E. Kuca-Warnawin, U. Skalska, M. Plebańczyk, I. Janicka, U. Musiałowicz, K. Bonek, P. Głuszko, E. Kontny
    Conference:
    39th European Workshop for rheumatology Research (EWRR), Lyon, Francja (rok: 2019, ), Wydawca: Annals of the Rheumatic Diseases 2019;78 (suppl1)
    Data:
    konferencja 28 luty - 3 marca
    Status:
    Published
  2. Differentiation of adipose derived mesenchymal stem cells obtained from patients with systemic lupus erythematosus, ankylosing spondylitis and systemic sclerosis.
    Authors:
    Ewa Kuca-Warnawin, Magdalena Plebańczyk, Anna Wajda, Krzysztof Bonek, Piotr Głuszko, Piotr Szczęsny, Marzena Olesińska, Włodzimierz Maśliński, Ewa Kontny
    Conference:
    Annual European Congress of Rheumatology, EULAR 2019, (rok: 2019, ), Wydawca: Ann Rheum Dis
    Data:
    konferencja 12-15.06.2019
    Status:
    Published
  3. Immunomodulatory activity of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients.
    Authors:
    E. Kuca-Warnawin, U. Skalska, I. Janicka, K. Bonek, P. Głuszko, W. Maśliński, E. Kontny
    Conference:
    39th European Workshop for Rheumatology Research (EWRR), Lyon, France (rok: 2019, ), Wydawca: Annals of the Rheumatic Diseases 2019;78 (suppl1)
    Data:
    konferencja 28 luty - 3 marca
    Status:
    Published

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