Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of gut bacteria and microbiota-derived methylamines in the regulation of arterial blood pressure and the development of hypertension.

2016/21/B/NZ5/02544

Keywords:

hypertension gut microbiota circulatory system

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology
  • NZ4_2: Physiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marcin Ufnal 

Number of co-investigators in the project: 3

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 864 900 PLN

Project start date (Y-m-d): 2017-01-24

Project end date (Y-m-d): 2020-02-23

Project duration:: 37 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Klatki metaboliczne (4 szt.) (16 000 PLN)
  2. Komputer (4 000 PLN)
  3. Sprzęt do rozbudowania systemu telemetrycznego do pomiarów hemodynamicznych, umożliwiający pomiary u 12 szczurów jednocześnie. (100 000 PLN)
  4. Termocykler RT-PCR (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.
    Authors:
    Jaworska K, Huc T, Samborowska E, Dobrowolski L, Bielinska K, Gawlak M, Ufnal M.
    Academic press:
    PLoS One (rok: 2017, tom: 12, strony: e0189310.), Wydawca: PLoS One
    Status:
    Published
    DOI:
    10.1371/journal.pone.0189310 - link to the publication
  2. Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats.
    Authors:
    Huć T, Nowinski A, Drapala A, Konopelski P, Ufnal M.
    Academic press:
    Pharmacological Research (rok: 2017, tom: 12, strony: 45310), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2017.12.025. - link to the publication
  3. Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.
    Authors:
    Huc T, Drapala A, Gawrys M, Konop M, Bielinska K, Zaorska E, Samborowska E, Wyczalkowska-Tomasik A, Pączek L, Dadlez M, Ufnal M.
    Academic press:
    Am J Physiol Heart Circ Physiol. (rok: 2018, tom: 315(6), strony: H1805-H1820), Wydawca: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpheart.00536.2018. - link to the publication
  4. Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker.
    Authors:
    Konop M, Radkowski M, Grochowska M, Perlejewski K, Samborowska E, Ufnal M.
    Academic press:
    Biomarkers. (rok: 2018, tom: 23(4), strony: 380-385.), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/1354750X.2018.1432689. - link to the publication
  5. Trimethylamine N-oxide: A harmful, protective or diagnostic marker in lifestyle diseases?
    Authors:
    Nowiński A, Ufnal M.
    Academic press:
    Nutrition (rok: 2018, tom: 46, strony: 45485), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nut.2017.08.001 - link to the publication
  6. Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa
    Authors:
    Piotr Konopelski 1 , Marek Konop 1 , Karol Perlejewski 2 , Iwona Bukowska-Osko 2 , Marek Radkowski, Maksymilian Onyszkiewicz, Kinga Jaworska, Izabella Mogilnicka, Emilia Samborowska , Marcin Ufnal
    Academic press:
    J Hypertension (rok: 2021, tom: 39, strony: 1790-1799), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/HJH.0000000000002864. - link to the publication
  7. High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats
    Authors:
    Bielinska K, Radkowski M, Grochowska M, Perlejewski K, Huc T, Jaworska K, Motooka D, Nakamura S, Ufnal M.
    Academic press:
    Nutrition (rok: 2018, tom: 54, strony: 33-39), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nut.2018.03.004. - link to the publication

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