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The role of gut bacteria and microbiota-derived methylamines in the regulation of arterial blood pressure and the development of hypertension.

2016/21/B/NZ5/02544

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ4_4: Patofizjologia ogólna
  • NZ4_2: Fizjologia

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Warszawski Uniwersytet Medyczny

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marcin Ufnal

Number of co-investigators in the project: 3

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
864 900 PLN
Project start date
2017-01-24
Project end date
2020-02-23
Project duration
37 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Klatki metaboliczne (4 pcs). Cost: 16 000 PLN
  2. Komputer. Cost: 4 000 PLN
  3. Sprzęt do rozbudowania systemu telemetrycznego do pomiarów hemodynamicznych, umożliwiający pomiary u 12 szczurów jednocześnie.. Cost: 100 000 PLN
  4. Termocykler RT-PCR. Cost: 60 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Genetically determined hypertensive phenotype affects gut microbiota composition, but not vice versa

    Authors:
    Piotr Konopelski 1 , Marek Konop 1 , Karol Perlejewski 2 , Iwona Bukowska-Osko 2 , Marek Radkowski, Maksymilian Onyszkiewicz, Kinga Jaworska, Izabella Mogilnicka, Emilia Samborowska , Marcin Ufnal
    Academic press:
    J Hypertension (year: 2021, volume: 39, pages: 1790-1799), Publisher: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/HJH.0000000000002864. – link to the publication

  2. Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressure via peripheral and central mechanisms in rats.

    Authors:
    Huć T, Nowinski A, Drapala A, Konopelski P, Ufnal M.
    Academic press:
    Pharmacological Research (year: 2017, volume: 12, pages: 46041), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.phrs.2017.12.025. – link to the publication

  3. Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker.

    Authors:
    Konop M, Radkowski M, Grochowska M, Perlejewski K, Samborowska E, Ufnal M.
    Academic press:
    Biomarkers. (year: 2018, volume: 23(4), pages: 380-385.), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/1354750X.2018.1432689. – link to the publication

  4. Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.

    Authors:
    Huc T, Drapala A, Gawrys M, Konop M, Bielinska K, Zaorska E, Samborowska E, Wyczalkowska-Tomasik A, Pączek L, Dadlez M, Ufnal M.
    Academic press:
    Am J Physiol Heart Circ Physiol. (year: 2018, volume: 315(6), pages: H1805-H1820), Publisher: American Physiological Society
    Status:
    Published
    DOI:
    10.1152/ajpheart.00536.2018. – link to the publication

  5. High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats

    Authors:
    Bielinska K, Radkowski M, Grochowska M, Perlejewski K, Huc T, Jaworska K, Motooka D, Nakamura S, Ufnal M.
    Academic press:
    Nutrition (year: 2018, volume: 54, pages: 33-39), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nut.2018.03.004. – link to the publication

  6. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.

    Authors:
    Jaworska K, Huc T, Samborowska E, Dobrowolski L, Bielinska K, Gawlak M, Ufnal M.
    Academic press:
    PLoS One (year: 2017, volume: 12, pages: e0189310.), Publisher: PLoS One
    Status:
    Published
    DOI:
    10.1371/journal.pone.0189310 – link to the publication

  7. Trimethylamine N-oxide: A harmful, protective or diagnostic marker in lifestyle diseases?

    Authors:
    Nowiński A, Ufnal M.
    Academic press:
    Nutrition (year: 2018, volume: 46, pages: 46215), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nut.2017.08.001 – link to the publication

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