Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular mechanisms of cardiac microvascular endothelial cell activation by autoreactive CD4+ T lymphocytes and inflammatory myeloid cells

2016/21/B/NZ5/01397

Keywords:

myocarditis cardiac microvascular endothelial cells TNF-alpha

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Błyszczuk 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 715 230 PLN

Project start date (Y-m-d): 2017-02-22

Project end date (Y-m-d): 2021-02-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. System Bioflux z mikroskopem fluorescencyjnym (485 000 PLN)
  2. Zestaw komputerowy wraz z oprogramowaniem (2 szt.) (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Complexity of TNF-α Signaling in Heart Disease
    Authors:
    Filip Rolski, Przemysław Błyszczuk
    Academic press:
    J Clin Med. (rok: 2020, tom: 9, strony: 45315), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9103267 - link to the publication
  2. Myocarditis in Humans and in Experimental Animal Models
    Authors:
    Przemysław Błyszczuk
    Academic press:
    Frontiers in Cardiovascular Medicine (rok: 2019, tom: 6, strony: 45308), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcvm.2019.00064 - link to the publication
  3. TNF-α protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4+ T cells
    Authors:
    Filip Rolski, Karolina Tkacz, Kazimierz Węglarczyk, Grzegorz Kwiatkowski, Paweł Pelczar, Agnieszka Jaźwa-Kusior, Anna Bar, Gabriela M Kuster, Stefan Chłopicki, Maciej Siedlar, Gabriela Kania, Przemysław Błyszczuk
    Academic press:
    Cardiovascular Research, (rok: 2023, tom: Online ahead of print cvad158, strony: Online ahead of print cvad158), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/cvr/cvad158 - link to the publication
  4. T Lymphocyte-Derived Exosomes Transport MEK1/2 and ERK1/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells
    Authors:
    Filip Rolski, Marcin Czepiel, Karolina Tkacz, Katarzyna Fryt, Maciej Siedlar, Gabriela Kania, Przemysław Błyszczuk
    Academic press:
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (rok: 2022, tom: eCollection 2022, strony: Article ID 2457687), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2022/2457687 - link to the publication
  1. TNF-alpha protects from exacerbated autoinflammatory response in mouse model of experimental autoimmune myocarditis
    Authors:
    F. Rolski, K. Weglarczyk, P. Pelczar, M. Siedlar, B. Ludewig, G. Kania, P. Blyszczuk
    Conference:
    ESC Congress (rok: 2020, ), Wydawca: Oxford University Press
    Data:
    konferencja 29 sierpnia - 1 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  2. Abstract 14723: Autoreactive T Lymphocytes Activate Cardiac Endothelium Independently of Tnf-α and Cause Endothelial Dysfunction Through Exosomes in Experimental Autoimmune Myocarditis
    Authors:
    Filip Rolski, Marcin Czepiel, Kazimierz Weglarczyk, Maciej Siedlar, Gabriela Kania and Przemysław Błyszczuk
    Conference:
    American Heart Association (rok: 2020, ), Wydawca: Circulation
    Data:
    konferencja 13-17.11.2020
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy