The application of the yeast model to investigate the genotoxic properties of antimony

2016/21/B/NZ2/01751

Keywords

Descriptors

  • NZ2_1: Genetyka molekularna

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Robert Wysocki

Number of co-investigators in the project: 5

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
673 420 PLN
Project start date
2017-02-09
Project end date
2021-02-08
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator z wytrząsaniem. Cost: 15 000 PLN
  2. Piec do hybrydyzacji. Cost: 13 000 PLN
  3. Zestaw do elektroforezy i transferu. Cost: 9 500 PLN
  4. Zestaw do elektroforezy kwasów nukleinowych. Cost: 7 500 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

    Authors:
    Ireneusz Litwin, Seweryn Mucha, Ewa Pilarczyk, Robert Wysocki, Ewa Maciaszczyk-Dziubinska
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4510 (1-30)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094510 – link to the publication
  2. Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

    Authors:
    Robert Wysocki, Joana I. Rodrigues, Ireneusz Litwin, Markus J. Tamás
    Academic press:
    Cellular and Molecular Life Sciences (year: 2023, volume: 80, pages: 342 (1-30)), Publisher: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s00018-023-04992-5 – link to the publication

Book publications / chapters in book publications (1)

  1. Chapter 12 Molecular mechanisms of antimony transport and detoxification

    Authors:
    Robert Wysocki
    Book:
    Antimony (year: 2021, volume: Brak, pages: 275-302), Publisher: Berlin, Boston: De Gruyter
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski