Projects funded by the NCN

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Modulation mitochondrial metabolism and dynamics and tageting DNA methylation of adipose derived mesenchymal stromal stem cell (ASC) using resveratrol and 5-azacytydin as a therapeutic strategy in the course of Equine metabolic syndrome (EMS).

2016/21/B/NZ7/01111

Keywords:

syndrom metaboliczny u koni cukrzyca u koni komórki macierzyste koni

Descriptors:

  • NZ7_13: Prevention of animal diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Biologii i Hodowli Zwierząt

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Marycz 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 894 270 PLN

Project start date (Y-m-d): 2017-01-24

Project end date (Y-m-d): 2019-11-23

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  1. 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy.
    Authors:
    Kornicka Katarzyna, Szłapka-Kosarzewska Jolanta, Śmieszek Agnieszka, Marycz Krzysztof
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2019, tom: 23, strony: 237–259), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/jcmm.13914 - link to the publication
  2. Combination of resveratrol and 5-azacytydine improves osteogenesis of metabolic syndrome mesenchymal stem cells.
    Authors:
    Marycz Krzysztof, Kornicka Katarzyna, Irwin-Houston Jennifer, Weiss Christine
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2018, tom: 22, strony: 4771-4793), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/jcmm.13731 - link to the publication
  3. Immunomodulatory Properties of Adipose-Derived Stem Cells Treated with 5-Azacytydine and Resveratrol on Peripheral Blood Mononuclear Cells and Macrophages in Metabolic Syndrome Animals.
    Authors:
    Kornicka Katarzyna, Śmieszek Agnieszka, Węgrzyn Agnieszka, Röcken Michael, Marycz Krzysztof
    Academic press:
    Journal of Clinical Medicine (rok: 2018, tom: 7, strony: 383), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm7110383 - link to the publication
  4. Systemic administration of rejuvenated adipose-derived mesenchymal stem cells improves liver metabolism in equine metabolic syndrome (EMS)- new approach in veterinary regenerative medicine.
    Authors:
    Marycz Krzysztod, Szłapka-Kosarzewska Jolanta, Geburek Florian, Kornicka Katarzyna
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 2019, strony: 45300), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.1007/s12015-019-09913-3 - link to the publication
  5. Advanced nutritional and stem cells approaches to prevent equine metabolic syndrome.
    Authors:
    Krzysztof Marycz, Izabela Michalak, Katarzyna Kornicka
    Academic press:
    Research in Veterinary Science (rok: 2018, tom: 118, strony: 115-125), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.rvsc.2018.01.015 - link to the publication
  6. Evaluation of oxidative stress and mitophagy during adipogenic differentiation of adipose derived stem cells isolated from Equine Metabolic Syndrome (EMS) horses.
    Authors:
    Krzysztof Marycz, Christine Weiss, Agnieszka Śmieszek, Katarzyna Kornicka
    Academic press:
    Stem Cells International (rok: 2018, tom: 2018, strony: 45309), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2018/5340756 - link to the publication
  7. Metformin Increases Proliferative Activity and Viability of Multipotent Stromal Stem Cells Isolated from Adipose Tissue Derived from Horses with Equine Metabolic Syndrome
    Authors:
    Agnieszka Smieszek, Katarzyna Kornicka, Jolanta Szłapka-Kosarzewska,Peter Androvic, Lukas Valihrach, Lucie Langerova, Eva Rohlova, Mikael Kubista, Krzysztof Marycz
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 80), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8020080 - link to the publication
  8. 5-azacytidine and resveratrol enhance chondrogenic differentiation of metabolic syndrome-derived mesenchymal stem cells by modulating autophagy
    Authors:
    Marycz Krzysztof, Jennifer Irwin Houston, Christine Weiss, Michael Röcken, Katarzyna Kornicka
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2019, tom: 2019, strony: 45311), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2019/1523140 - link to the publication
  9. Characterization of Apoptosis, Autophagy and Oxidative Stress in Pancreatic Islets Cells and Intestinal Epithelial Cells Isolated from Equine Metabolic Syndrome (EMS) Horses.
    Authors:
    Kornicka Katarzyna, Śmieszek Agnieszka, Szłapka-Kosarzewska Jolanta, Irwin Houston Jennifer, Roecken Michael, Marycz Krzysztof
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 3068), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19103068 - link to the publication
  10. The Effect of Chronic Inflammation and Oxidative and Endoplasmic Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy
    Authors:
    Michalina Alicka and Krzysztof Marycz
    Academic press:
    Stem Cells International (rok: 2018, tom: 2018, strony: 45304), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2018/4274361 - link to the publication
  11. Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their potential therapeutic use.
    Authors:
    Katarzyna Kornicka, Jenny Houston, Krzysztof Marycz
    Academic press:
    Stem Cell Reviews and Reports (rok: 2018, tom: 14, strony: 337-345), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-018-9809-x - link to the publication
  12. Excessive Endoplasmic Reticulum Stress Correlates with Impaired Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose Tissue, but Not in Muscles in EMS Horses
    Authors:
    Krzysztof Marycz, Katarzyna Kornicka, Jolanta-Szłapka Kosarzewska, Christine Weiss
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19010165. - link to the publication
  13. Microvesicles isolated from 5-azacytidine-and-resveratrol-treated mesenchymal stem cells for the treatment of suspensory ligament injury in horse—a case report
    Authors:
    Katarzyna Kornicka-Garbowska, Rafał Pędziwiatr, Paulina Woźniak, Katarzyna Kucharczyk,Krzysztof Marycz
    Academic press:
    Stem Cell Research & Therapy (rok: 2019, tom: 10, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s13287-019-1469-5 - link to the publication
  14. Stem Cells in Equine Veterinary Practice—Current Trends, Risks, and Perspectives
    Authors:
    Katarzyna Kornicka, Florian Geburek, Michael Röcken, and Krzysztof Marycz
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 8, strony: 675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm8050675 - link to the publication

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