Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The study of the contribution of telomerase regulation to cancer cells resistance to DNA-damaging drugs

2016/21/B/NZ7/01079

Keywords:

telomerase drug resistance ABC cancer DNA damage migration adhesion

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Błażej Rubiś 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 316 100 PLN

Project start date (Y-m-d): 2017-01-24

Project end date (Y-m-d): 2020-07-23

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik fluorescencji (200 000 PLN)
  2. Kamera chłodzona do chemiluminescencji z oprogramowaniem.
  3. Pipety (3 szt.) (12 000 PLN)
  4. Zamrażarka niskotemperaturowa (40 000 PLN)
  5. Kamera do mikroskopu Zeiss (12 000 PLN)
  6. Komputer z systemem antyprzepięciowym i back up oraz oprogramowaniem (8 000 PLN)
  7. Mieszadło magnetyczne (5 000 PLN)
  8. Pojemnik do przechowywania komórek w ciekłym azocie (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Telomere length: how the length makes a difference
    Authors:
    M. Lulkiewicz, J. Bajsert, P. Kopczynski, W. Barczak, B. Rubis
    Academic press:
    Molecular Biology Reports (rok: 2020, tom: w trakcie, strony: w trakcie), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-020-05551-y - link to the publication
  2. The non-canonical functions of telomerase: to turn off or not to turn off
    Authors:
    Aleksandra Romaniuk, Anna Paszel-Jaworska, Ewa Totoń, Natalia Lisiak, Hanna Hołysz, Anna Królak, Sylwia Grodecka-Gazdecka, Błażej Rubiś
    Academic press:
    Molecular Biology Reports (rok: 2018, tom: 17, strony: tba), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-018-4496-x - link to the publication
  3. Vitamin C as a Modulator of the Response to Cancer Therapy
    Authors:
    Wiktoria Błaszczak, Wojciech Barczak, Julia Masternak, Przemysław Kopczyński, Anatoly Zhitkovich, Błażej Rubiś
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 453), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules24030453 - link to the publication
  4. Telomerase inhibitor TMPyP4 alters adhesion and migration of breast-cancer cells MCF7 and MDA-MB-231.
    Authors:
    Natalia Konieczna, Aleksandra Romaniuk-Drapała, Natalia Lisiak, Ewa Totoń, Anna Paszel-Jaworska, Mariusz Kaczmarek, Błażej Rubiś.
    Academic press:
    Int. J. Mol. Sci. (rok: 2019, tom: 20, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20112670 - link to the publication
  5. hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells
    Authors:
    Aleksandra Romaniuk-Drapała, Ewa Totoń, Natalia Konieczna, Marta Machnik, Wojciech Barczak, Dagmar Kowal, Przemysław Kopczyński, Mariusz Kaczmarek, Błażej Rubiś
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 867/1-21), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10040867 - link to the publication
  6. Potential of Naturally Derived Compounds in Telomerase and Telomere Modulation in Skin Senescence and Aging
    Authors:
    Barbara Jacczak, Błażej Rubiś, Ewa Totoń
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1636675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126381 - link to the publication
  7. Telomerase and drug resistance in cancer
    Authors:
    Natalia Lipinska, Aleksandra Romaniuk, Anna Paszel-Jaworska, Ewa Toton, Przemyslaw Kopczynski, Blazej Rubis
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2017, tom: 74, strony: 4121-4132), Wydawca: SpringerLink
    Status:
    Published
    DOI:
    10.1007/s00018-017-2573-2 - link to the publication