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Epigenetic modifications of insulin pathway genes and their role in obesity-induced insulin resistance

2016/21/D/NZ5/00155

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Małgorzata Małodobra-Mazur

Number of co-investigators in the project: 4

Call

SONATA 11 – announced on 2016-03-15

Amount awarded
494 680 PLN
Project start date
2017-02-24
Project end date
2021-08-23
Project duration
54 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. KOMPUTER FUJITSU ESPRIMO.
  2. Sonikator. Cost: 35 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. PPARG hypermethylation as the first epigenetic modification in newly onset insulin resistance in human adipocytes.

    Authors:
    [AUT. KORESP.] MAŁGORZATA MAŁODOBRA-MAZUR, [AUT.] ANETA CIERZNIAK, KRZYSZTOF KALISZEWSKI, TADEUSZ DOBOSZ
    Academic press:
    Genes (year: 2021, volume: 12, pages: art.889 [12 s.]), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12060889 – link to the publication

  2. The preliminary evaluation of epigenetic modifications regulating the expression of IL10 in insulin-resistant adipocytes

    Authors:
    Aneta Cierzniak, Krzysztof Kaliszewski, Małgorzata Małodobra-Mazur
    Academic press:
    Genes (year: 2022, volume: 13, pages: 294), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13020294 – link to the publication

  3. Histone modifications influence the insulin-signaling genes and are related to insulin resistance in human adipocytes.

    Authors:
    MAŁGORZATA MAŁODOBRA-MAZUR, [AUT.] ANETA CIERZNIAK, ANETA MYSZCZYSZYN, KRZYSZTOF KALISZEWSKI, TADEUSZ DOBOSZ
    Academic press:
    Int.J.Biochem.Cell Biol. (year: 2021, volume: 137, pages: art.106031 [11 s.]), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2021.106031 – link to the publication

  4. DNA methylation in adipocytes from visceral and subcutaneous adipose tissue influences insulin-signaling gene expression in obese individuals

    Authors:
    Aneta Cierzniak , Dorota Pawelka , Krzysztof Kaliszewski , Jerzy Rudnicki , Tadeusz Dobosz , Malgorzata Malodobra-Mazur
    Academic press:
    International Journal of Obesity (year: 2021, volume: 45, pages: 650-658), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41366-020-00729-7 – link to the publication

Articles in post-conference publications (2)

  1. The impact of epigenetic on insulin resistance in adipose tissue: in vivo study

    Authors:
    MAŁGORZATA MAŁODOBRA-MAZUR, ANETA ALAMA, DOROTA PAWEŁKA
    Conference:
    55th EASD Annual Meeting of the European Association for the Study of Diabetes (year: 2019, pages: S136 poz.269), Publisher: Diabetologia [EASD]
    Date:
    conference 16-20 wrzesień
    Status:
    Published

  2. Metabolic differences between subcutaneous and visceral adipose tissues based on gene expression study

    Authors:
    ANETA CIERZNIAK, KRZYSZTOF KALISZEWSKI, MAŁGORZATA MAŁODOBRA-MAZUR
    Conference:
    4th International Wroclaw Scientific Meetings. (year: 2020, pages: 94-96), Publisher: Wydawnictwo Naukowe TYGIEL
    Date:
    conference 09-10 październik
    Status:
    Published

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