Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Epigenetic modifications of insulin pathway genes and their role in obesity-induced insulin resistance

2016/21/D/NZ5/00155

Keywords:

obesity insulin resistance insulin pathway DNA methylation histone modifications

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Małodobra-Mazur 

Number of co-investigators in the project: 4

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 494 680 PLN

Project start date (Y-m-d): 2017-02-24

Project end date (Y-m-d): 2021-08-23

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. KOMPUTER FUJITSU ESPRIMO.
  2. Sonikator (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. DNA methylation in adipocytes from visceral and subcutaneous adipose tissue influences insulin-signaling gene expression in obese individuals
    Authors:
    Aneta Cierzniak , Dorota Pawelka , Krzysztof Kaliszewski , Jerzy Rudnicki , Tadeusz Dobosz , Malgorzata Malodobra-Mazur
    Academic press:
    International Journal of Obesity (rok: 2021, tom: 45, strony: 650-658), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41366-020-00729-7 - link to the publication
  2. PPARG hypermethylation as the first epigenetic modification in newly onset insulin resistance in human adipocytes.
    Authors:
    [AUT. KORESP.] MAŁGORZATA MAŁODOBRA-MAZUR, [AUT.] ANETA CIERZNIAK, KRZYSZTOF KALISZEWSKI, TADEUSZ DOBOSZ
    Academic press:
    Genes (rok: 2021, tom: 12, strony: art.889 [12 s.]), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12060889 - link to the publication
  3. Histone modifications influence the insulin-signaling genes and are related to insulin resistance in human adipocytes.
    Authors:
    MAŁGORZATA MAŁODOBRA-MAZUR, [AUT.] ANETA CIERZNIAK, ANETA MYSZCZYSZYN, KRZYSZTOF KALISZEWSKI, TADEUSZ DOBOSZ
    Academic press:
    Int.J.Biochem.Cell Biol. (rok: 2021, tom: 137, strony: art.106031 [11 s.]), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2021.106031 - link to the publication
  4. The preliminary evaluation of epigenetic modifications regulating the expression of IL10 in insulin-resistant adipocytes
    Authors:
    Aneta Cierzniak, Krzysztof Kaliszewski, Małgorzata Małodobra-Mazur
    Academic press:
    Genes (rok: 2022, tom: 13, strony: 294), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes13020294 - link to the publication
  1. Metabolic differences between subcutaneous and visceral adipose tissues based on gene expression study
    Authors:
    ANETA CIERZNIAK, KRZYSZTOF KALISZEWSKI, MAŁGORZATA MAŁODOBRA-MAZUR
    Conference:
    4th International Wroclaw Scientific Meetings. (rok: 2020, ), Wydawca: Wydawnictwo Naukowe TYGIEL
    Data:
    konferencja 09-10 październik
    Status:
    Published
  2. The impact of epigenetic on insulin resistance in adipose tissue: in vivo study
    Authors:
    MAŁGORZATA MAŁODOBRA-MAZUR, ANETA ALAMA, DOROTA PAWEŁKA
    Conference:
    55th EASD Annual Meeting of the European Association for the Study of Diabetes (rok: 2019, ), Wydawca: Diabetologia [EASD]
    Data:
    konferencja 16-20 wrzesień
    Status:
    Published

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