Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Nano- and microstructures formed by self-assembly of block copolymers - preparation and applications as carriers for bioactive substances

2016/21/B/ST5/00250

Keywords:

polymersomes coacervates polymeric micelles copolymers polyelectrolytes confocal microscopy TEM microscopy

Descriptors:

  • ST5_21:
  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Mariusz Kępczyński 

Number of co-investigators in the project: 8

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 912 800 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2021-02-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. mieszadło magnetyczne z grzaniem.
  2. wytrząsarka typu vortex.
  3. Dysk przenośny (366 PLN)
  4. Mikrokalorymetr ITC (320 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Drug-loading capacity of polylactide-based micro- and nanoparticles – Experimental and molecular modeling study
    Authors:
    M. Zatorska, G. Łazarski, U. Maziarz, N. Wilkosz, T. Honda, S. Yusa, J. Bednar, D. Jamróz, M. Kepczynski
    Academic press:
    International Journal of Pharmaceutics (rok: 2020, tom: 591, strony: 120031), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2020.120031 - link to the publication
  2. Molecular Insight into Drug-Loading Capacity of PEG−PLGA Nanoparticles for Itraconazole
    Authors:
    Natalia Wilkosz, Grzegorz Łazarski, Lubomir Kovacik, Patrycja Gargas, Maria Nowakowska, Dorota Jamróz, Mariusz Kepczynski
    Academic press:
    The Journal of Physical Chemistry B (rok: 2018, tom: 122, strony: 7080-7090), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.8b03742 - link to the publication
  3. Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor
    Authors:
    Fabio Lolicato, Hanna Juhola, Agata Zak, Pekka A. Postila, Annina Saukko, Sami Rissanen, Giray Enkavi, Ilpo Vattulainen, Mariusz Kepczynski, Tomasz Róg
    Academic press:
    ACS Chemical Neuroscience (rok: 2020, tom: 11, strony: 1914−1924), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.9b00656 - link to the publication
  4. Polycation−Anionic Lipid Membrane Interactions
    Authors:
    W. Kopec, A. Żak, D. Jamróz, R. Nakahata, S. Yusa, V. Gapsys, M. Kepczynski
    Academic press:
    Langmuir (rok: 2020, tom: 36, strony: 12435−12450), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.0c01062 - link to the publication
  5. Molecular Mechanism of Polycation-Induced Pore Formation in Biomembranes
    Authors:
    N. Awasthi, W. Kopec, N. Wilkosz, D. Jamróz, J.S. Hub, M. Zatorska, R. Petka, M. Nowakowska, M. Kepczynski
    Academic press:
    ACS Biomaterials Science & Engineering (rok: 2019, tom: 5, strony: 780-794), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsbiomaterials.8b01495 - link to the publication
  6. Complex Behavior of Phosphatidylcholine−Phosphatidic Acid Bilayers and Monolayers: Effect of Acyl Chain Unsaturation
    Authors:
    Waldemar Kulig, Hanna Korolainen, Maria Zatorska, Urszula Kwolek, Paweł Wydro, Mariusz Kepczynski, Tomasz Róg
    Academic press:
    Langmuir (rok: 2019, tom: 35, strony: 5944−5956), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.9b00381 - link to the publication
  7. Encapsulation of Curcumin in Polystyrene-Based NanoparticlesDrug Loading Capacity and Cytotoxicity
    Authors:
    Maria Zatorska-Płachta, Grzegorz Łazarski, Urszula Maziarz, Aleksander Foryś, Barbara Trzebicka, Dawid Wnuk, Karolina Chołuj, Anna Karewicz, Marta Michalik, Dorota Jamróz, Mariusz Kepczynski
    Academic press:
    ACS Omega (rok: 2021, tom: 6, strony: 12168−12178), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.1c00867 - link to the publication

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