Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Modified siRNAs, ribozymes and CRISPR/Cas system as strategies for influenza A virus inhibition. Application and comparison of RNA-targeting methods.

2016/21/N/NZ1/00565

Keywords:

influenza virus siRNA RNAi ribozyme hammerhead CRISPR Cas9

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Julita Piasecka 

Number of co-investigators in the project: 2

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 149 960 PLN

Project start date (Y-m-d): 2017-03-16

Project end date (Y-m-d): 2021-03-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zestaw komputerowy (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure
    Authors:
    Kesy J, Patil KM, Kumar SR, Shu ZY, Yong HY, Zimmermann L, Ong AAL, Toh DFK, Krishna MS, Yang LX, Decout JL, Luo DH, Prabakaran M, Chen G, Kierzek E
    Academic press:
    Bioconjugate Chemistry (rok: 2019, tom: 30, strony: 931-943), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.9b00039 - link to the publication
  2. RNA Secondary Structure Motifs of the Influenza A Virus as Targets for siRNA-Mediated RNA Interference
    Authors:
    Piasecka J, Lenartowicz E, Soszynska-Jozwiak M, Szutkowska B, Kierzek R, Kierzek E
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2020, tom: 19, strony: 627-642), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2019.12.018 - link to the publication
  3. Organization of the Influenza A Virus Genomic RNA in the Viral Replication Cycle-Structure, Interactions, and Implications for the Emergence of New Strains
    Authors:
    Piasecka J, Jarmolowicz A, Kierzek E
    Academic press:
    Pathogens (rok: 2020, tom: 9, strony: 951), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens9110951 - link to the publication
  4. Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides
    Authors:
    Michalak P, Soszynska-Jozwiak M, Biala E, Moss WN, Kesy J, Szutkowska B, Lenartowicz E, Kierzek R, Kierzek E
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 3801), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-40443-7 - link to the publication
  5. Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA
    Authors:
    Michalak P, Piasecka J, Szutkowska B, Kierzek R, Biala E, Moss WN, Kierzek E
    Academic press:
    Viruses (rok: 2021, tom: 13, strony: 525), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v13030525 - link to the publication

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