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Epigenetic changes leading to remodeling of chromatin structure and alterations in gene expression in replicative and premature senescence of vascular smooth muscle cells; histone H3 modifications and the involvement of HP1 alpha

2016/21/B/NZ3/00370

Keywords:

H3K9me3 HP1 alpha senescence VSMC

Descriptors:

  • NZ3_1:
  • NZ3_4:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Bielak-Żmijewska 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 999 800 PLN

Project start date (Y-m-d): 2017-02-01

Project end date (Y-m-d): 2022-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells
    Authors:
    Agnieszka Gadecka, Natalia Nowak, Edyta Bulanda, Dorota Janiszewska, Magdalena Dudkowska, Ewa Sikora, Anna Bielak-Zmijewska*
    Academic press:
    GeroScience (rok: 2025, tom: 47, strony: 3907-3925), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-024-01504-6 - link to the publication
  2. Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of senescence
    Authors:
    Gadecka A, Koblowska M, Kossowska H, Iwanicka-Nowicka R, Janiszewska D, Mosieniak G, Bojakowski K, Goryca K, Bielak-Zmijewska A
    Academic press:
    Cell Communication and Signaling (rok: 2025, tom: 23, strony: 321), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-025-02315-8 - link to the publication
  3. Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome
    Authors:
    A. Gadecka, A. Bielak-Żmijewska
    Academic press:
    Nutrients (rok: 2019, tom: 11, strony: 1251), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11061251 - link to the publication
  4. Targeting normal and cancer senescent cells as a strategy of senotherapy
    Authors:
    E.Sikora, A. Bielak-Żmijewska, G. Mosieniak
    Academic press:
    Ageing Research Reviews (rok: 2019, tom: 55, strony: 100941), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2019.100941 - link to the publication
  5. A common signature of cellular senescence; does it exist?
    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G
    Academic press:
    Ageing Research Reviews (rok: 2021, tom: 71, strony: 101458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101458 - link to the publication
  6. The Role of Curcumin in the Modulation of Ageing
    Authors:
    A. Bielak-Zmijewska, W. Grabowska, A. Ciolko, A. Bojko , G. Mosieniak, L. Bijoch, E. Sikora
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(5), strony: pii: E1239), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20051239 - link to the publication
  7. Mechanizmy regulujące strukturę chromatyny oraz zmiany towarzyszące starzeniu komórkowemu
    Authors:
    Gadecka A, Bielak-Żmijewska A
    Academic press:
    Postępy Biochemii (rok: 2025, tom: 71, strony: 61-78), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_590 - link to the publication

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