Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular signature of osteoinductive materials - attempting to standardize in vitro evaluation of biomaterials

2016/21/B/NZ5/00217

Keywords:

human mesenchymal stem cells bone morphogenetic proteins osteoinductive surfaces and scaffolds 2D and 3D cultures dynamic cultures in perfusion bioreactor ectopic bone formation in vivo

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ1_8: Tissue engineering
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Osyczka 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 964 600 PLN

Project start date (Y-m-d): 2017-04-19

Project end date (Y-m-d): 2021-04-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. PCR w czasie rzeczywistym - dofinansowanie zakupu.
  2. Czytnik Elisa z modułem do odczytu luminescencji (117 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. The role of CaO/SiO2 ratio and P2O5 content in gel-derived bioactive glass-polymer composites in the modulation of their bioactivity and osteoinductivity in human BMSCs
    Authors:
    K. Łukowicz, B. Zagrajczuk, A. Nowak, Ł. Niedżwiedzki, M. Łączka, K. Cholewa-Kowalska, A.M. Osyczka
    Academic press:
    Materias Science and Engineering C (rok: 2020, tom: 109, strony: art. no. 110535), Wydawca: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110535 - link to the publication
  2. Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration
    Authors:
    Krzysztof Łukowicz, Barbara Zagrajczuk, Karolina Truchan, Łukasz Niedzwiedzki, Katarzyna Cholewa-Kowalska, Anna M Osyczka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: Feb 26; 23(5):2598, strony: 11 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052598 - link to the publication
  3. Physicochemical properties of scaffolds based on mixtures of chitosan, collagen and glycosaminoglycans with nano-hydroxyapatite addition
    Authors:
    B. Kaczmarek, A. Sionkowska, A.M. Osyczka
    Academic press:
    International Journal of Biological Macromolecules (rok: 2018, tom: 15, strony: 1880-1883), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2018.07.035. - link to the publication
  4. Antibacterial activity and cytocompatibility of bone cement enriched with antibiotic, nanosilver, and nanocopper for bone regeneration
    Authors:
    M. Wekwejt, A. Michno, K. Truchan, A. Pałubicka, B. Świeczko-Żurek, A.M. Osyczka, A. Zieliński
    Academic press:
    Nanomaterials (rok: 2019, tom: 9, strony: art. no. 1114), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano9081114 - link to the publication
  5. Properties of scaffolds based on chitosan and collagen with bioglass 45S5
    Authors:
    Beata Kaczmarek, Kinga Nadolna, Agata Owczarek, Olha Mazur, Alina Sionkowska, Krzysztof Łukowicz, Jithin Vishnu, Geetha Manivasagam, Anna M. Osyczka
    Academic press:
    IET Nanobiotechnology (rok: 2020, tom: 14, strony: 830-832), Wydawca: The Institution of Engineering and Technology 2020
    Status:
    Published
    DOI:
    10.1049/iet-nbt.2020.0045 - link to the publication
  6. Collagen-based scaffolds enriched with glycosaminoglycans isolated from skin of Salmo salar fish
    Authors:
    B. Kaczmarek, A. Sionkowska, A.M. Osyczka
    Academic press:
    Polymer Testing (rok: 2017, tom: 62, strony: 132-136), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymertesting.2017.06.022 - link to the publication
  7. Connexin 43 in osteogenesis
    Authors:
    Łukowicz K, Fijał K, Nowak A, Osyczka AM
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2020, tom: 74, strony: 406-415), Wydawca: Instytut Immunologii i Terapii Doświadczalnej PAN we Wrocławiu
    Status:
    Published
    DOI:
    10.5604/01.3001.0014.4153 - link to the publication
  8. Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties
    Authors:
    M. Wekwejt, M. Michalska-Sionkowska, M. Bartmański, M. Nadolska, K. Łukowicz, A. Pałubicka, A.M. Osyczka, A. Zieliński
    Academic press:
    Materials Science & Engineering C (rok: 2020, tom: 117, strony: Nr 111286), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.111286 - link to the publication
  9. Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties
    Authors:
    M. Wekwejt, S. Chen, B. Kaczmarek-Szczepańska, M. Nadolska, K. Łukowicz, A. Pałubicka, A. Michno, A. M. Osyczka, M. Michálek and A. Zieliński
    Academic press:
    Biomaterials Science (rok: 2021, tom: 9, strony: 3112), Wydawca: The Royal Society of Chemistry 2021
    Status:
    Published
    DOI:
    10.1039/d1bm00079a - link to the publication
  10. Scaffolds based on chitosan and collagen with glycosaminoglycans crosslinked by tannic acid
    Authors:
    B.Kaczmarek, A.Sionkowska, A.M.Osyczka
    Academic press:
    Polymer Testing (rok: 2018, tom: 65, strony: 163-168), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymertesting.2017.11.026 - link to the publication
  11. Molecular Indicators of Biomaterials Osteoinductivity - Cell Migration, BMP Production and Signalling Turns a Key
    Authors:
    Krzysztof Łukowicz, Barbara Zagrajczuk, Jarosław Wieczorek, Katarzyna Millan-Ciesielska, Izabela Polkowska, Katarzyna Cholewa-Kowalska, Anna M Osyczka
    Academic press:
    Stem Cell Rev Rep (rok: 2021, tom: 45612, strony: 19 stron), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-021-10300-0 - link to the publication
  12. New insights into the PLGA and PCL blending: Physico-mechanical properties and cell response
    Authors:
    J. Pawlik, K. Łukowicz, K. Cholewa-Kowalska, A.M.Osyczka
    Academic press:
    Materials Research Express (rok: 2019, tom: 6, strony: art no. 085344), Wydawca: IOPScience
    Status:
    Published
    DOI:
    10.1088/2053-1591/ab2823 - link to the publication

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