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Molecular signature of osteoinductive materials - attempting to standardize in vitro evaluation of biomaterials

2016/21/B/NZ5/00217

Keywords

Descriptors

  • NZ3_8: Komórki macierzyste
  • NZ1_8: Inżynieria tkankowa
  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński, Wydział Biologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Anna Maria Osyczka

Number of co-investigators in the project: 7

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
964 600 PLN
Project start date
2017-04-19
Project end date
2021-04-18
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik Elisa z modułem do odczytu luminescencji. Cost: 117 000 PLN
  2. PCR w czasie rzeczywistym - dofinansowanie zakupu.

Information in the final report

Publication in academic press/journals (12)

  1. Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration

    Authors:
    Krzysztof Łukowicz, Barbara Zagrajczuk, Karolina Truchan, Łukasz Niedzwiedzki, Katarzyna Cholewa-Kowalska, Anna M Osyczka
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: Feb 26; 23(5):2598, pages: 11 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23052598 – link to the publication

  2. Molecular Indicators of Biomaterials Osteoinductivity - Cell Migration, BMP Production and Signalling Turns a Key

    Authors:
    Krzysztof Łukowicz, Barbara Zagrajczuk, Jarosław Wieczorek, Katarzyna Millan-Ciesielska, Izabela Polkowska, Katarzyna Cholewa-Kowalska, Anna M Osyczka
    Academic press:
    Stem Cell Rev Rep (year: 2021, volume: 46342, pages: 19 stron), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-021-10300-0 – link to the publication

  3. The role of CaO/SiO2 ratio and P2O5 content in gel-derived bioactive glass-polymer composites in the modulation of their bioactivity and osteoinductivity in human BMSCs

    Authors:
    K. Łukowicz, B. Zagrajczuk, A. Nowak, Ł. Niedżwiedzki, M. Łączka, K. Cholewa-Kowalska, A.M. Osyczka
    Academic press:
    Materias Science and Engineering C (year: 2020, volume: 109, pages: art. no. 110535), Publisher: ScienceDirect
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110535 – link to the publication

  4. Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties

    Authors:
    M. Wekwejt, S. Chen, B. Kaczmarek-Szczepańska, M. Nadolska, K. Łukowicz, A. Pałubicka, A. Michno, A. M. Osyczka, M. Michálek and A. Zieliński
    Academic press:
    Biomaterials Science (year: 2021, volume: 9, pages: 3112), Publisher: The Royal Society of Chemistry 2021
    Status:
    Published
    DOI:
    10.1039/d1bm00079a – link to the publication

  5. Properties of scaffolds based on chitosan and collagen with bioglass 45S5

    Authors:
    Beata Kaczmarek, Kinga Nadolna, Agata Owczarek, Olha Mazur, Alina Sionkowska, Krzysztof Łukowicz, Jithin Vishnu, Geetha Manivasagam, Anna M. Osyczka
    Academic press:
    IET Nanobiotechnology (year: 2020, volume: 14, pages: 830-832), Publisher: The Institution of Engineering and Technology 2020
    Status:
    Published
    DOI:
    10.1049/iet-nbt.2020.0045 – link to the publication

  6. Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties

    Authors:
    M. Wekwejt, M. Michalska-Sionkowska, M. Bartmański, M. Nadolska, K. Łukowicz, A. Pałubicka, A.M. Osyczka, A. Zieliński
    Academic press:
    Materials Science & Engineering C (year: 2020, volume: 117, pages: Nr 111286), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.111286 – link to the publication

  7. Collagen-based scaffolds enriched with glycosaminoglycans isolated from skin of Salmo salar fish

    Authors:
    B. Kaczmarek, A. Sionkowska, A.M. Osyczka
    Academic press:
    Polymer Testing (year: 2017, volume: 62, pages: 132-136), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymertesting.2017.06.022 – link to the publication

  8. Scaffolds based on chitosan and collagen with glycosaminoglycans crosslinked by tannic acid

    Authors:
    B.Kaczmarek, A.Sionkowska, A.M.Osyczka
    Academic press:
    Polymer Testing (year: 2018, volume: 65, pages: 163-168), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.polymertesting.2017.11.026 – link to the publication

  9. Connexin 43 in osteogenesis

    Authors:
    Łukowicz K, Fijał K, Nowak A, Osyczka AM
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (year: 2020, volume: 74, pages: 406-415), Publisher: Instytut Immunologii i Terapii Doświadczalnej PAN we Wrocławiu
    Status:
    Published
    DOI:
    10.5604/01.3001.0014.4153 – link to the publication

  10. New insights into the PLGA and PCL blending: Physico-mechanical properties and cell response

    Authors:
    J. Pawlik, K. Łukowicz, K. Cholewa-Kowalska, A.M.Osyczka
    Academic press:
    Materials Research Express (year: 2019, volume: 6, pages: art no. 085344), Publisher: IOPScience
    Status:
    Published
    DOI:
    10.1088/2053-1591/ab2823 – link to the publication

  11. Antibacterial activity and cytocompatibility of bone cement enriched with antibiotic, nanosilver, and nanocopper for bone regeneration

    Authors:
    M. Wekwejt, A. Michno, K. Truchan, A. Pałubicka, B. Świeczko-Żurek, A.M. Osyczka, A. Zieliński
    Academic press:
    Nanomaterials (year: 2019, volume: 9, pages: art. no. 1114), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nano9081114 – link to the publication

  12. Physicochemical properties of scaffolds based on mixtures of chitosan, collagen and glycosaminoglycans with nano-hydroxyapatite addition

    Authors:
    B. Kaczmarek, A. Sionkowska, A.M. Osyczka
    Academic press:
    International Journal of Biological Macromolecules (year: 2018, volume: 15, pages: 1880-1883), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2018.07.035. – link to the publication

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Graphic design and implementation: Jakub Piotrowski