Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Looking for biomarkers of rheumatic diseases - comprehensive study of metabolomic profile, polymorphisms and expression of IL-23/Th17 pathway genes and miRNA molecules

2016/21/B/NZ5/01901

Keywords:

rheumatic disorders IL-23/Th17 signalling pathway metabolomic profile miRNA repertoire gene polymorphisms and expression

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Katarzyna Bogunia-Kubik 

Number of co-investigators in the project: 11

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 500 720 PLN

Project start date (Y-m-d): 2017-02-07

Project end date (Y-m-d): 2021-02-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do real-time PCR umożliwiający analizę 96 lub 384 próbek jednocześnie wraz z oprogramowaniem i stacją sterującą pracą urządzenia.

Information in the final report

  • Publication in academic press/journals (15)
  1. Disease Differentiation and Monitoring of Anti-TNF Treatment in Rheumatoid Arthritis and Spondyloarthropathies
    Authors:
    Bogunia-Kubik K, Wojtowicz W, Swierkot J, Mielko KA, Qasem B, Wielińska J, Sokolik R, Pruss Ł, Młynarz P
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(14), strony: 7389), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute), Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms22147389 - link to the publication
  2. IL-33 gene polymorphisms as potential biomarkers of disease susceptibility and response to TNF inhibitors in rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis patients.
    Authors:
    Iwaszko M, Wielińska J, Świerkot J, Kolossa K, Sokolik R, Bugaj B, Chaszczewska-Markowska M, Jeka S, Bogunia-Kubik K.
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 12, strony: 631603), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.631603 - link to the publication
  3. Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis.
    Authors:
    Gębura K, Świerkot J, Wysoczańska B, Korman L, Nowak B, Wiland P, Bogunia-Kubik K.
    Academic press:
    International Journal of Molecular Sciences (Int J Mol Sci.) (rok: 2017, tom: 18(7), strony: 1432), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute), Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms18071432 - link to the publication
  4. Relationship Between Interleukin-6 -174G/C Genetic Variant and Efficacy of Methotrexate Treatment in Psoriatic Arthritis Patients.
    Authors:
    Sokolik R, Iwaszko M, Świerkot J, Wysoczańska B, Korman L, Wiland P, Bogunia-Kubik K.
    Academic press:
    Pharmacogenomics and Personalized Medicine (rok: 2021, tom: 14, strony: 157-166), Wydawca: Dove Press
    Status:
    Published
    DOI:
    10.2147/PGPM.S264555 - link to the publication
  5. Validation of GWAS-identified variants for anti-TNF drug response in rheumatoid arthritis: a meta-analysis of two large cohorts.
    Authors:
    Sánchez-Maldonado JM, Cáliz R, López-Nevot MÁ, Cabrera- Serrano AJ, Moñiz-Díez A, Canhao H, Horst RT, Quartuccio L, Sorensen SB, Glintborg B, Hetland ML, Filipescu I, Pérez-Pampin E, Conesa-Zamora P, Swierkot J, Den Broeder A, De Vita S, Petersen ER, Li Y, Ferrer MÁ, Escudero A, Netea MG, Coenen M, Andersen V, Fonseca JE, Jurado M, Bogunia-Kubik K, Collantes E, Sainz J.
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 12, strony: 672255), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.672255 - link to the publication
  6. Changes in miRNA-5196 expression as a potential biomarker of anti-TNF-α therapy in rheumatoid arthritis and ankylosing spondylitis patients.
    Authors:
    Ciechomska M, Bonek K, Merdas M, Zarecki P, Swierkot J, Gluszko P, Bogunia-Kubik K, Maslinski W.
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (Arch Immun Ther Exp.) (rok: 2018, tom: 66, strony: 389-397), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-018-0513-y. - link to the publication
  7. Shared Epitope and polymorphism of MICA and NKG2D encoding genes in Greek and Polish patients with rheumatoid arthritis
    Authors:
    Wielińska J, Tarassi K, Iwaszko M, Kościńska K, Wysoczańska B, Mole E, Kitsiou Świerkot J, Kolossa K, Kouniaki D, Athanassiades T, Tsirogianni A, Bogunia-Kubik K.
    Academic press:
    Central European Journal of Immunology (rok: 2021, tom: 46(1), strony: 92-98), Wydawca: Termedia Publishing House
    Status:
    Published
    DOI:
    10.5114/ceji.2021.104425 - link to the publication
  8. IL-6 gene polymorphism is associated with protein serum level and disease activity in Polish patients with rheumatoid arthritis.
    Authors:
    Wielińska J, Dratwa M, Świerkot J, Korman L, Iwaszko M, Wysoczańska B, Bogunia-Kubik K.
    Academic press:
    HLA (rok: 2018, tom: 92 Suppl 2, strony: 38-41), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/tan.13355. - link to the publication
  9. MicroRNAs as potential biomarkers of treatment outcome in rheumatoid arthritis and ankylosing spondylitis.
    Authors:
    Wielińska J, Bogunia-Kubik K.
    Academic press:
    Pharmacogenomics (rok: 2021, tom: 22(5), strony: 291-301), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/pgs-2020-0148. - link to the publication
  10. Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors
    Authors:
    Wielińska J, Crossland RE, Łacina P, Świerkot J, Bugaj B, Dickinson A, Bogunia-Kubik K.
    Academic press:
    Disease Markers (rok: 2021, tom: 2021, strony: 2924935), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/2924935 - link to the publication
  11. Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis.
    Authors:
    Iwaszko M, Świerkot J, Dratwa M, Wysoczańska B, Korman L, Bugaj B, Kolossa K, Jeka S, Wiland P, Bogunia-Kubika K.
    Academic press:
    The Pharmacogenomics Journal (Pharmacogenomics J.) (rok: 2020, tom: 20(6), strony: 760-769), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41397-020-0164-3 - link to the publication
  12. Influence of NKG2D genetic variants on response to anti-TNF agents in patients with rheumatoid arthritis.
    Authors:
    Iwaszko M, Świerkot J, Kolossa K, Jeka S, Wiland P, Bogunia-Kubik K.
    Academic press:
    Genes (rok: 2018, tom: 9(2), strony: 64), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute), Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/genes9020064 - link to the publication
  13. Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis
    Authors:
    Wielińska J, Świerkot J, Kolossa K, Bugaj B, Chaszczewska-Markowska M, Jeka S, Bogunia-Kubik K.
    Academic press:
    Mediators of Inflammation (rok: 2021, tom: 2021, strony: 3125922), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/3125922 - link to the publication
  14. Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment
    Authors:
    Wielińska J, Kolossa K, Świerkot J, Dratwa M, Iwaszko M, Bugaj B, Wysoczańska B, Chaszczewska-Markowska M, Jeka S, Bogunia-Kubik K.
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2020, tom: 68(4), strony: 24), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-020-00590-6 - link to the publication
  15. Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
    Authors:
    Iwaszko M, Biały S, Bogunia-Kubik K
    Academic press:
    Cells (rok: 2021, tom: 10(11), strony: 3000), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute), Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/cells10113000 - link to the publication

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