Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mitotic catastrophe and amplicon loss as a basis of negative selection of glioblastoma cells with oncogene amplicons

2016/21/D/NZ3/02616

Keywords:

mitotic catastrophe amplicon oncogene primary culture glioblastoma mitotic death senescence apoptosis

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis
  • NZ3_4: Ageing

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski, Oddział Nauk Biomedycznych

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewelina Stoczyńska-Fidelus 

Number of co-investigators in the project: 5

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 588 500 PLN

Project start date (Y-m-d): 2017-03-02

Project end date (Y-m-d): 2020-08-01

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Chłodziarko-zamrażarka +4/-20°C (3 000 PLN)
  2. Spektrofotometr umożliwiający pomiar niewielkich objętości (40 000 PLN)
  3. System umożliwiający obserwację i kwantyfikację zmian biologicznych komórek w czasie rzeczywistym (światło widzialne, fluorescencja) (40 000 PLN)
  4. Zestaw do analizy Western Blot z zasilaczem (15 000 PLN)
  5. Komputer (3 500 PLN)
  6. Zamrażarka niskotemperaturowa -80°C z zabezpieczeniem CO2. (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (7)
  1. A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena
    Authors:
    Karolina Janik Cezary Treda Jolanta Zieba Piotr Rieske Joanna Peciak Roza Pawlowska Aneta Wlodarczyk Waldemar Och Ewelina Stoczynska-Fidelus
    Academic press:
    BMC Cancer (rok: 2019, tom: 19(1), strony: 923), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12885-019-6130-2 - link to the publication
  2. EGFRvIII: An Oncogene with Ambiguous Role
    Authors:
    Rutkowska A, Stoczyńska-Fidelus E, Janik K, Włodarczyk A, Rieske P
    Academic press:
    Journal of Oncology (rok: 2019, tom: 2019, strony: 45311), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1092587 - link to the publication
  3. Glioblastoma with BRAFV600E mutation and numerous metastatic foci: a case report
    Authors:
    Karolina Janik, Waldemar Och, Marta Popeda, Kamila Rosiak, Joanna Peciak, Piotr Rieske, Kamil Kulbacki, Blazej Szostak, Agnieszka Parda, Ewelina Stoczynska-Fidelus
    Academic press:
    Folia Neuropathologica (rok: 2019, tom: 57(1), strony: 45299), Wydawca: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells
    Authors:
    Aneta Wlodarczyk, Dagmara Grot, Ewelina Stoczynska-Fidelus, Piotr Rieske
    Academic press:
    Journal of Oncology (rok: 2020, tom: 2020, strony: 2020:6783627), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/6783627 - link to the publication
  5. Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation
    Authors:
    Wojciech Stec, Kamila Rosiak, Cezary Treda, Maciej Smolarz, Joanna Peciak, Marcin Pacholczyk, Anna Lenart, Dawid Grzela, Ewelina Stoczynska-Fidelus and Piotr Rieske
    Academic press:
    Oncotarget (rok: 2018, tom: 9(9), strony: 8560-8572), Wydawca: Oncotraget
    Status:
    Published
    DOI:
    10.18632/oncotarget.24058 - link to the publication
  1. HOMODIMERIZATION AS THE MAIN MECHANISM OF EGFRVIII ACTIVATION
    Authors:
    Adrianna Rutkowska, Cezary Tręda, Marcin Pacholczyk, Aneta Włodarczyk, Sylwia Janiszewska, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIIIrd Gliwice Scientific Meetings 2019 (rok: 2019, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 22-23 November
    Status:
    Published
  2. ADAPTATION OF GLIOBLASTOMA CELLS WITH AMPLICONS TO IN VITRO CONDITIONS – LOSS OF AMPLICONS IN A FORM OF EXTRACHROMOSOMAL VESICLES AND EGF-MEDIATED SENESCENCE
    Authors:
    Karolina Janik, Weronika Dobrewa, Piotr Rieske, Joanna Pęciak, Cezary Tręda, Ewelina Stoczyńska-Fidelus
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (rok: 2018, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 16-17 listopada 2018
    Status:
    Published
  3. Immunocytochemical analysis of the specificity of EGFRvIII binding L8A4 antibody in tumor cell lines
    Authors:
    Adrianna Rutkowska, Cezary Tręda, Aneta Włodarczyk, Dagmara Grot, Ewelina Stoczynska-Fidelus, Piotr Rieske
    Conference:
    VIIIth Intercollegiate Biotechnology Symposium Symbioza (rok: 2019, ), Wydawca: Warszawskie Stowarzyszenie Biotechnologiczne (WSB) "Symbioza"
    Data:
    konferencja 17-19 May
    Status:
    Published
  4. THE EGFRVIII GENE EXPRESSION ITSELF IS INSUFFICIENT TO ASSURANCE THE INCREASED SURVIVAL AND PROLIFERATION OF GLIOBLASTOMA CELL LINES
    Authors:
    Aneta Włodarczyk, Joanna Pęciak, Karolina Janik, Cezary Tręda, Katarzyna Wasiak, Marcin Ciechanowski, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (rok: 2018, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 16-17 listopada 2018
    Status:
    Published
  5. EXTREMELY LOW CONCENTRATION OF EGFRVIII MRNA IS SUFFICIENT TO KEEP THIS ONCOGENE PROTEIN AT DETECTABLE LEVEL
    Authors:
    Aneta Włodarczyk, Joanna Pęciak, Cezary Tręda, Karolina Janik, Krystyna Hułas-Bigoszewska, Adrianna Rutkowska, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (rok: 2018, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 16-17 listopada 2018
    Status:
    Published
  6. Pharmacogenomic platform to test therapeutic molecules - in search of the mechanism underlying negative in vitro selection of tumor cells with oncogene amplicons
    Authors:
    Karolina Janik, Cezary Treda, Wojciech Stec, Kamila Rosiak, Piotr Rieske, Marcin Ciechanowski, Ewelina Stoczynska-Fidelus
    Conference:
    XXIst Gliwice Scientific Meetings (rok: 2017, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska-Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 17-18 listopada
    Status:
    Published
  7. VARIABLE POSITION OF DISULFIDE BRIDGES IN EGFRVIII MONOMERS AND COVALENT DIMERS CAN NOT ADVERSELY AFFECT L8A4 BASED CAR-T THERAPY
    Authors:
    Aneta Włodarczyk, Cezary Tręda, Marcin Pacholczyk, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIIIrd Gliwice Scientific Meetings 2019 (rok: 2019, ), Wydawca: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Data:
    konferencja 22-23 November
    Status:
    Published

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