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Mitotic catastrophe and amplicon loss as a basis of negative selection of glioblastoma cells with oncogene amplicons

2016/21/D/NZ3/02616

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ3_3: Apoptoza
  • NZ3_4: Starzenie

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Lekarski; Oddział Nauk Biomedycznych

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Ewelina Stoczyńska-Fidelus

Number of co-investigators in the project: 5

Call

SONATA 11 – announced on 2016-03-15

Amount awarded
588 500 PLN
Project start date
2017-03-02
Project end date
2020-08-01
Project duration
41 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Chłodziarko-zamrażarka +4/-20°C. Cost: 3 000 PLN
  2. Komputer. Cost: 3 500 PLN
  3. Spektrofotometr umożliwiający pomiar niewielkich objętości. Cost: 40 000 PLN
  4. System umożliwiający obserwację i kwantyfikację zmian biologicznych komórek w czasie rzeczywistym (światło widzialne, fluorescencja). Cost: 40 000 PLN
  5. Zamrażarka niskotemperaturowa -80°C z zabezpieczeniem CO2.. Cost: 45 000 PLN
  6. Zestaw do analizy Western Blot z zasilaczem. Cost: 15 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Glioblastoma with BRAFV600E mutation and numerous metastatic foci: a case report

    Authors:
    Karolina Janik, Waldemar Och, Marta Popeda, Kamila Rosiak, Joanna Peciak, Piotr Rieske, Kamil Kulbacki, Blazej Szostak, Agnieszka Parda, Ewelina Stoczynska-Fidelus
    Academic press:
    Folia Neuropathologica (year: 2019, volume: 57(1), pages: 46030), Publisher: Polish Association of Neuropathologists and M. Mossakowski Medical Research Centre of the Polish Academy of Sciences
    Status:
    Published

  2. A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena

    Authors:
    Karolina Janik Cezary Treda Jolanta Zieba Piotr Rieske Joanna Peciak Roza Pawlowska Aneta Wlodarczyk Waldemar Och Ewelina Stoczynska-Fidelus
    Academic press:
    BMC Cancer (year: 2019, volume: 19(1), pages: 923), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12885-019-6130-2 – link to the publication

  3. Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation

    Authors:
    Wojciech Stec, Kamila Rosiak, Cezary Treda, Maciej Smolarz, Joanna Peciak, Marcin Pacholczyk, Anna Lenart, Dawid Grzela, Ewelina Stoczynska-Fidelus and Piotr Rieske
    Academic press:
    Oncotarget (year: 2018, volume: 9(9), pages: 8560-8572), Publisher: Oncotraget
    Status:
    Published
    DOI:
    10.18632/oncotarget.24058 – link to the publication

  4. EGFRvIII: An Oncogene with Ambiguous Role

    Authors:
    Rutkowska A, Stoczyńska-Fidelus E, Janik K, Włodarczyk A, Rieske P
    Academic press:
    Journal of Oncology (year: 2019, volume: 2019, pages: 46042), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1092587 – link to the publication

  5. Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells

    Authors:
    Aneta Wlodarczyk, Dagmara Grot, Ewelina Stoczynska-Fidelus, Piotr Rieske
    Academic press:
    Journal of Oncology (year: 2020, volume: 2020, pages: 2020:6783627), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/6783627 – link to the publication

Articles in post-conference publications (7)

  1. EXTREMELY LOW CONCENTRATION OF EGFRVIII MRNA IS SUFFICIENT TO KEEP THIS ONCOGENE PROTEIN AT DETECTABLE LEVEL

    Authors:
    Aneta Włodarczyk, Joanna Pęciak, Cezary Tręda, Karolina Janik, Krystyna Hułas-Bigoszewska, Adrianna Rutkowska, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (year: 2018, pages: 84), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 16-17 listopada 2018
    Status:
    Published

  2. ADAPTATION OF GLIOBLASTOMA CELLS WITH AMPLICONS TO IN VITRO CONDITIONS – LOSS OF AMPLICONS IN A FORM OF EXTRACHROMOSOMAL VESICLES AND EGF-MEDIATED SENESCENCE

    Authors:
    Karolina Janik, Weronika Dobrewa, Piotr Rieske, Joanna Pęciak, Cezary Tręda, Ewelina Stoczyńska-Fidelus
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (year: 2018, pages: 83), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 16-17 listopada 2018
    Status:
    Published

  3. Pharmacogenomic platform to test therapeutic molecules - in search of the mechanism underlying negative in vitro selection of tumor cells with oncogene amplicons

    Authors:
    Karolina Janik, Cezary Treda, Wojciech Stec, Kamila Rosiak, Piotr Rieske, Marcin Ciechanowski, Ewelina Stoczynska-Fidelus
    Conference:
    XXIst Gliwice Scientific Meetings (year: 2017, pages: 96), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska-Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 17-18 listopada
    Status:
    Published

  4. Immunocytochemical analysis of the specificity of EGFRvIII binding L8A4 antibody in tumor cell lines

    Authors:
    Adrianna Rutkowska, Cezary Tręda, Aneta Włodarczyk, Dagmara Grot, Ewelina Stoczynska-Fidelus, Piotr Rieske
    Conference:
    VIIIth Intercollegiate Biotechnology Symposium Symbioza (year: 2019, pages: 208), Publisher: Warszawskie Stowarzyszenie Biotechnologiczne (WSB) Symbioza
    Date:
    conference 17-19 May
    Status:
    Published

  5. VARIABLE POSITION OF DISULFIDE BRIDGES IN EGFRVIII MONOMERS AND COVALENT DIMERS CAN NOT ADVERSELY AFFECT L8A4 BASED CAR-T THERAPY

    Authors:
    Aneta Włodarczyk, Cezary Tręda, Marcin Pacholczyk, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIIIrd Gliwice Scientific Meetings 2019 (year: 2019, pages: 86), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 22-23 November
    Status:
    Published

  6. THE EGFRVIII GENE EXPRESSION ITSELF IS INSUFFICIENT TO ASSURANCE THE INCREASED SURVIVAL AND PROLIFERATION OF GLIOBLASTOMA CELL LINES

    Authors:
    Aneta Włodarczyk, Joanna Pęciak, Karolina Janik, Cezary Tręda, Katarzyna Wasiak, Marcin Ciechanowski, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIInd Gliwice Scientific Meetings 2018 (year: 2018, pages: 85), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 16-17 listopada 2018
    Status:
    Published

  7. HOMODIMERIZATION AS THE MAIN MECHANISM OF EGFRVIII ACTIVATION

    Authors:
    Adrianna Rutkowska, Cezary Tręda, Marcin Pacholczyk, Aneta Włodarczyk, Sylwia Janiszewska, Ewelina Stoczyńska-Fidelus, Piotr Rieske
    Conference:
    XXIIIrd Gliwice Scientific Meetings 2019 (year: 2019, pages: 64), Publisher: Association for the Support of Cancer Research, Center of Oncology Maria Sklodowska- Curie Memorial Institute Branch in Gliwice, Silesian University of Technology, Gliwice
    Date:
    conference 22-23 November
    Status:
    Published

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