Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Functional investigation of MiR92b-3p for diagnosis and miRNA-based cure in chemically induced liver injury in fish

2016/21/B/NZ9/03566

Keywords:

RNA interference Locked Nucleic Acids hepatotoxicity mechanism microcystin liver regeneration whitefish toxicogenomics

Descriptors:

  • NZ9_11: Biohazards, biological containment, biosafety, biosecurity
  • NZ7_2: Environment and health risks

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Paweł Brzuzan 

Number of co-investigators in the project: 9

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 525 750 PLN

Project start date (Y-m-d): 2017-01-16

Project end date (Y-m-d): 2021-01-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Moduł do pomiaru fluorescencji do urządzenia GloMax®-Multi+ (15 000 PLN)
  2. Komora laminarna II klasy bezpieczeństwa biologicznego Esco Airstream (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. De Novo Profiling of Long Non-Coding RNAs Involved in MC-LR-Induced Liver Injury in Whitefish: Discovery and Perspectives
    Authors:
    Florczyk M, Brzuzan P, Woźny M
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(2), strony: 941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020941 - link to the publication
  2. In vivo miRNA delivery in whitefish: Synthetic MiR92b-3p uptake and the efficacy of gene expression silencing
    Authors:
    Paweł Brzuzan, Maciej Woźny , Bogdan Lewczuk, Maciej Florczyk , Piotr Gomułka, Paulina Budzińska, Michał Wesołowski, Stefan Dobosz
    Academic press:
    Experimental Biology and Medicine (rok: 2019, tom: 244, strony: 52-63), Wydawca: Sage Publishers
    Status:
    Published
    DOI:
    10.1177/1535370218824573 - link to the publication
  3. Functional investigation of MiR92b-3p for diagnosis and miRNA-based cure in chemically induced liver injury in fish: a project description
    Authors:
    Paweł Brzuzan, Maciej Woźny, Maciej Florczyk
    Academic press:
    Environmental Biotechnology (rok: 2017, tom: 12(2), strony: 40-42), Wydawca: University ofr Warmia and Mazury in Olsztyn, Poland
    Status:
    Published
    DOI:
    10.14799/ebms287 - link to the publication

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