Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The involvement of the dopaminergic system in maternal separation-stress induced vulnerability to eating disorders

2016/21/B/NZ4/00204

Keywords:

maternal separation stress binge eating reward system ventral tegmental area

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Hess 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 055 150 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2020-02-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Doposażenie stanowiska do pomiarów elektrofizjologicznych metodą "patch clamp" ze skrawków mózgu (385 000 PLN)
  2. Monitor Dell (700 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Early-life stress modifies the reactivity of neurons in the ventral tegmental area and lateral hypothalamus to acute stress in female rats
    Authors:
    Gugula A., Trenk A., Celary A., Cizio K, Tylko G., Blasiak A., Hess G.
    Academic press:
    Neuroscience (rok: 2021, tom: b.d., strony: b.d.), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    b.d. - link to the publication
  2. RLN3/RXFP3 signaling in the PVN inhibits magnocellular neurons via M-like current activation and contributes to binge eating behavior
    Authors:
    Kania A., Szlaga A., Sambak A., Guguła A., Błasiak A., Micioni Di Bonaventura M.V., Hossain M.A., Cifani C., Hess G., Gundlach A.L., Błasiak A.
    Academic press:
    Journal of Neuroscience (rok: 2020, tom: 40, strony: 5362-5375), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.2895-19.2020 - link to the publication
  3. Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats
    Authors:
    Spyrka J., Guguła A., Rak A., Tylko G., Hess G., Błasiak A.
    Academic press:
    Neurobiology of Stress (rok: 2020, tom: 13, strony: 100250), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ynstr.2020.100250 - link to the publication
  1. Early life stress influences mesocorticolimbic pathways of female rats by altering dendritic spine density in ventral tegmental area
    Authors:
    Guguła A., Celary A., Tylko G., Hess G., Błasiak A.
    Conference:
    FENS Regional Meeting 2019 (rok: 2019, ), Wydawca: Federation of European Neuroscience Societies
    Data:
    konferencja 43656
    Status:
    Published
  2. Maternal separation modifies dendritic spine density in ventral tegmental area neurons in a sub-region-specific manner: study in female rats
    Authors:
    Celary A., Guguła A., Tylko G., Hess G., Błasiak A.
    Conference:
    14th International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 43705
    Status:
    Published
  3. Maternal separation stress alters excitability and stress induced c-fos expression in ventral tegmental area dopaminergic neurons of adult female rats
    Authors:
    Guguła A., Spyrka J., Cizio K., Hess G., Błasiak A.
    Conference:
    14th International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 43705
    Status:
    Published
  4. Early life stress decreases excitability of VTA neurons - implications for stress induced alteration in reward system functioning
    Authors:
    Spyrka J., Devaux Q., Hess G., Błasiak A.
    Conference:
    11th FENS Forum of Neuroscience (rok: 2018, ), Wydawca: Federation of European Neuroscience Societies
    Data:
    konferencja 7 - 11.07
    Status:
    Published

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