The involvement of the dopaminergic system in maternal separation-stress induced vulnerability to eating disorders

2016/21/B/NZ4/00204

Keywords

Descriptors

  • NZ4_7: Neurofizjologia
  • NZ4_9: Neurobiologia systemowa

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Jagielloński, Wydział Biologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Grzegorz Władysław Hess

Number of co-investigators in the project: 5

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
1 055 150 PLN
Project start date
2017-02-17
Project end date
2020-02-16
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Doposażenie stanowiska do pomiarów elektrofizjologicznych metodą "patch clamp" ze skrawków mózgu. Cost: 385 000 PLN
  2. Monitor Dell. Cost: 700 PLN

Information in the final report

Publication in academic press/journals (2)

  1. RLN3/RXFP3 signaling in the PVN inhibits magnocellular neurons via M-like current activation and contributes to binge eating behavior

    Authors:
    Kania A., Szlaga A., Sambak A., Guguła A., Błasiak A., Micioni Di Bonaventura M.V., Hossain M.A., Cifani C., Hess G., Gundlach A.L., Błasiak A.
    Academic press:
    Journal of Neuroscience (year: 2020, volume: 40, pages: 5362-5375), Publisher: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.2895-19.2020 – link to the publication
  2. Early life stress-induced alterations in the activity and morphology of ventral tegmental area neurons in female rats

    Authors:
    Spyrka J., Guguła A., Rak A., Tylko G., Hess G., Błasiak A.
    Academic press:
    Neurobiology of Stress (year: 2020, volume: 13, pages: 100250), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ynstr.2020.100250 – link to the publication

Articles in post-conference publications (4)

  1. Early life stress influences mesocorticolimbic pathways of female rats by altering dendritic spine density in ventral tegmental area

    Authors:
    Guguła A., Celary A., Tylko G., Hess G., Błasiak A.
    Conference:
    FENS Regional Meeting 2019 (year: 2019, pages: Abstracts; P 175), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 43656
    Status:
    Published
  2. Early life stress decreases excitability of VTA neurons - implications for stress induced alteration in reward system functioning

    Authors:
    Spyrka J., Devaux Q., Hess G., Błasiak A.
    Conference:
    11th FENS Forum of Neuroscience (year: 2018, pages: B015), Publisher: Federation of European Neuroscience Societies
    Date:
    conference 7 - 11.07
    Status:
    Published
  3. Maternal separation modifies dendritic spine density in ventral tegmental area neurons in a sub-region-specific manner: study in female rats

    Authors:
    Celary A., Guguła A., Tylko G., Hess G., Błasiak A.
    Conference:
    14th International Congress of the Polish Neuroscience Society (year: 2019, pages: Supplement/2019; P 1.7), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 43705
    Status:
    Published
  4. Maternal separation stress alters excitability and stress induced c-fos expression in ventral tegmental area dopaminergic neurons of adult female rats

    Authors:
    Guguła A., Spyrka J., Cizio K., Hess G., Błasiak A.
    Conference:
    14th International Congress of the Polish Neuroscience Society (year: 2019, pages: Supplement/2019; P9.2), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 43705
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski