Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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In Search for the novel therapeutic strategies in the treatment of brain ischemia. Determination of the neuroprotective activity of AP39, the new H2S donor, in the model of focal brain ischemia in rats.

2016/21/D/NZ4/03302

Keywords:

MCAo brain ischemia hydrogen sulfide ischemia apoptosis

Descriptors:

  • NZ7_15: Toxicology
  • NZ4_9: Systems neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Bartosz Pomierny 

Number of co-investigators in the project: 2

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 499 380 PLN

Project start date (Y-m-d): 2017-02-24

Project end date (Y-m-d): 2022-02-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kriostat (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Identification of optimal reference genes for gene expression studies in a focal cerebral ischaemia model—Spatiotemporal effects
    Authors:
    Pomierny Bartosz, Krzyżanowską Weronika, Jurczyk Jakub, Strach Beata, Skórkowska Alicja, Innesa Leonovich, Budziszewska Bogusława, Pera Joanna
    Academic press:
    Jounal of Cellular and Molecular Medicine (rok: 2022, ), Wydawca: Wiley
    Status:
    Accepted for publication
    DOI:
    10.1111/jcmm.17284 - link to the publication
  2. The Slow-Releasing and Mitochondria-Targeted Hydrogen Sulfide (H2S) Delivery Molecule AP39 Induces Brain Tolerance to Ischemia
    Authors:
    Bartosz Pomierny, Weronika Krzyżanowska, Jakub Jurczyk, Alicja Skórkowska, Beata Strach, Małgorzata Szafarz, Katarzyna Przejczowska-Pomierny, Roberta Torregrossa, Matthew Whiteman, Monika Marcinkowska, Joanna Pera, and Bogusława Budziszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45316), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22157816 - link to the publication

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