Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Searching for high biological activity of legume seeds based on different levels of molecular modelling

2016/21/B/NZ9/00898

Keywords:

isoflavones isothermal titration calorymetry molecular modeling cell lines high bioactivity

Descriptors:

  • NZ9_7: Nutrition and food sciences

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grażyna Budryn 

Number of co-investigators in the project: 10

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 451 880 PLN

Project start date (Y-m-d): 2017-01-23

Project end date (Y-m-d): 2020-01-22

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Cicer arietinum L. sprouts' influence on mineralization of saos-2 and migration of MCF-7 cells
    Authors:
    Zakłos-Szyda M., Gałązka-Czarnecka I., Grzelczyk J., Budryn G.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4490), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25194490 - link to the publication
  2. Evaluation of estrogenic activity of red clover (Trifolium pratense L.) sprouts cultivated under different conditions by content of isoflavones, calorimetric study and molecular modelling
    Authors:
    Budryn G., Gałązka-Czarnecka I., Brzozowska E., Grzelczyk J., Mostowski R., Żyżelewicz D., Cerón-Carrasco J.P., Pérez-Sánchez H.
    Academic press:
    Food Chemistry (rok: 2018, tom: 245, strony: 324-326), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.100 - link to the publication
  3. The effects of Trifolium pratense L. sprouts' phenolic compounds on cell growth and migration of MDA-MB-231, MCF-7 and HUVEC cells
    Authors:
    Zakłos-Szyda, M., Budryn G.
    Academic press:
    Nutrients (rok: 2020, tom: 12, strony: 257), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12010257 - link to the publication
  4. Evaluation of isoflavones as bone resorption inhibitors upon interactions with receptor activator of nuclear factor-kB ligand (RANKL)
    Authors:
    Zakłos-Szyda, M., Budryn, G., Grzelczyk, J., Pérez-Sánchez, H., Żyżelewicz, D.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 206), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010206 - link to the publication
  5. Lactic acid fermentation of legume seed sprouts as a method of increasing the content of isoflavones and reducing microbial contamination
    Authors:
    Budryn, G., Klewicka, E., Grzelczyk, J., Gałązka-Czarnecka, I., Mostowski, R.
    Academic press:
    Food Chemistry (rok: 2019, tom: 285, strony: 478-484), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.foodchem.2019.01.178 - link to the publication
  6. Binding of red clover isoflavones to actin as a potential mechanism of anti-metastatic activity Restricting the migration of cancer cells
    Authors:
    Budryn, G., Grzelczyk J. Pérez-Sánchez, H.
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2471), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules2310247 - link to the publication

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