Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Impaired angiogenesis in Duchenne muscular dystrophy - is there a role for heme oxygenase-1 and statins?

2016/21/B/NZ1/00293

Keywords:

angiogenesis statins HO-1 induced pluripotent stem cells iPSC DMD

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Łoboda 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 244 100 PLN

Project start date (Y-m-d): 2017-02-09

Project end date (Y-m-d): 2021-02-08

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dysk zewnętrznzy (414 PLN)
  2. Zestaw komputerowy.

Information in the final report

  • Publication in academic press/journals (13)
  • Articles in post-conference publications (2)
  1. Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system
    Authors:
    Mucha O, Podkalicka P, Czarnek M, Biela A. Mieczkowski M, Kachamakova-Trojanowska N, Stepniewski J, Jozkowicz A, Dulak J, Loboda A.
    Academic press:
    Acta Biochimica Polonica (rok: 2018, tom: 65, strony: 277-286), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2017_2542 - link to the publication
  2. Dysregulated Autophagy and Mitophagy in a Mouse Model of Duchenne Muscular Dystrophy Remain Unchanged Following Heme Oxygenase-1 Knockout
    Authors:
    Mucha O, Kaziród K, Podkalicka P, Rusin K, Dulak J, Łoboda A
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 470-487), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010470 - link to the publication
  3. Heme oxygenase inhibition in cancers: Possible tools and targets
    Authors:
    Podkalicka P, Mucha O, Józkowicz A, Dulak J, Łoboda A.
    Academic press:
    Contemporary Oncology (rok: 2017, tom: 2, strony: 23-32), Wydawca: Termedia Publishing House Ltd.
    Status:
    Published
    DOI:
    10.5114/wo.2018.73879 - link to the publication
  4. Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
    Authors:
    Podkalicka P, Stępniewski J, Mucha O, Kachamakova-Trojanowska N, Dulak J, Łoboda A.
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 1614-1644), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10121614. - link to the publication
  5. Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future
    Authors:
    Łoboda A, Dulak J
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 1227-1263), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00134-x. - link to the publication
  6. Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy
    Authors:
    Mucha O, Podkalicka P, Kaziród K, Dulak J, Łoboda A.
    Academic press:
    Skeletal Muscle (rok: 2021, tom: 11, strony: 21-37), Wydawca: BioMed Central Ltd. Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13395-021-00276-3 - link to the publication
  7. Molekularne mechanizmy dystrofii mięśniowej Duchenne'a i nowe możliwości terapeutyczne
    Authors:
    Podkalicka P, Myszka M, Dulak J, Łoboda A
    Academic press:
    Postępy Biochemii (rok: 2022, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  8. Heme Oxygenase-1 Influences Satellite Cells and Progression of Duchenne Muscular Dystrophy in Mice.
    Authors:
    Pietraszek-Gremplewicz K, Kozakowska M, Bronisz-Budzynska I, Ciesla M, Mucha O, Podkalicka P, Madej M, Glowniak U, Szade K, Stepniewski J, Jez M, Andrysiak K, Bukowska-Strakova K, Kaminska A, Kostera-Pruszczyk A, Jozkowicz A, Loboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Signaling (rok: 2018, tom: 29, strony: 128-148), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/ars.2017.7435. - link to the publication
  9. Lack of miR-378 attenuates muscular dystrophy in mdx mice
    Authors:
    Podkalicka P, Mucha O, Bronisz-Budzyńska I, Kozakowska M, Pietraszek-Gremplewicz K, Cetnarowska A, Głowniak-Kwitek U, Bukowska-Strakova K, Cieśla M, Kulecka M, Ostrowski J, Mikuła M, Potulska-Chromik A, Kostera-Pruszczyk A, Józkowicz A, Łoboda A, Dulak J.
    Academic press:
    JCI Insight (rok: 2020, tom: 5, strony: e135576), Wydawca: American Society for Clinical Investigation (ASCI)
    Status:
    Published
    DOI:
    10.1172/jci.insight.135576. - link to the publication
  10. Targeting angiogenesis in Duchenne muscular dystrophy
    Authors:
    Podkalicka P, Mucha O, Dulak J, Loboda A.
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2019, tom: 76, strony: 1507–1528), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03006-7 - link to the publication
  11. Age-dependent dysregulation of muscle vasculature and blood flow recovery after hindlimb ischemia in the mdx model of Duchenne Muscular Dystrophy
    Authors:
    Podkalicka P, Mucha O, Kaziród K, Bronisz-Budzyńska I, Ostrowska-Paton S, Tomczyk M, Andrysiak K, Stępniewski J, Dulak J, Łoboda A.
    Academic press:
    Biomedicines (rok: 2021, tom: 9, strony: 481-506), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9050481 - link to the publication
  12. The role of Nrf2 in acute and chronic muscle injury
    Authors:
    Bronisz-Budzyńska I, Kozakowska M, Podkalicka P, Kachamakova-Trojanowska N, Łoboda A, Dulak J.
    Academic press:
    Skeletal Muscle (rok: 2020, tom: 10, strony: 22), Wydawca: BioMed Central Ltd. Part of Springer Nature.
    Status:
    Published
    DOI:
    10.1186/s13395-020-00255-0. - link to the publication
  13. miR-146a deficiency does not aggravate muscular dystrophy in mdx mice.
    Authors:
    Bronisz-Budzyńska I, Chwalenia K, Mucha O, Podkalicka P, Bukowska-Strakova K, Józkowicz A, Łoboda A, Kozakowska M, Dulak J.
    Academic press:
    Skeletal Muscle (rok: 2019, tom: 9, strony: 45308), Wydawca: BMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
    Status:
    Published
    DOI:
    10.1186/s13395-019-0207-0 - link to the publication
  1. Heme oxygenase-1 modulates angiogenesis related alterations in murine model of Duchenne muscular dystrophy
    Authors:
    O. Mucha, P. Podkalicka, M. Tomczyk, K. Rusin, I. Bronisz-Budzynska, M. Kozakowska, A. Jozkowicz, J. Dulak, A. Loboda
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published
  2. The lack of miR-378 attenuates dystrophic phenotype in mdx mice through decreased inflammation, fibrosis and systemic metabolic alterations
    Authors:
    P. Podkalicka, O. Mucha, M. Kozakowska, K. Pietraszek-Gremplewicz, I. Bronisz-Budzynska, J. Ostrowski, M. Mikula, A. Jozkowicz, A. Loboda, J. Dulak
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 43652
    Status:
    Published

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