Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of exogenous hormonally active compounds in the biology of human granulosa tumors.

2016/21/B/NZ7/01080

Keywords:

Endocrine disrupting chemicals human granulosa tumors viability anoikis invasion

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ3_1: Cell biology
  • NZ4_6: Endocrinology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anna Ptak 

Number of co-investigators in the project: 5

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 834 900 PLN

Project start date (Y-m-d): 2017-02-09

Project end date (Y-m-d): 2020-08-08

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikroskop odwrócony z jasnym polem, kontrastem fazowym i fluorescencyjnym wraz z kamerą i oprogramowaniem do analizy obrazu (135 000 PLN)
  2. Zamrażalka niskotemperturowa -86° o pojemości 86l (20 000 PLN)
  3. Inkubator IL 23 DIGITAL. AMB..

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate IGF1 secretion by adult ovarian granulosa cell tumor spheroids and thereby increase proliferation of non-cancer ovarian granulosa cells
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Academic press:
    Toxicol In Vitro (rok: 2020, tom: 8, strony: 65:104769), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2020.104769 - link to the publication
  2. Disruption of 17β-estradiol secretion by persistent organic pollutants present in human follicular fluid is dependent on the potential of ovarian granulosa tumor cell lines to metabolize estrogen
    Authors:
    Gogola J, Hoffmann M, Nimpsz S, Ptak A
    Academic press:
    Molecular and Cellular Endocrinology (rok: 2020, tom: 1, strony: 503:110698), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2019.110698 - link to the publication
  3. Mixtures of persistent organic pollutants increase ovarian granulosa tumor cell line migration and spheroid invasion by upregulating MMP2 expression and activity via IGF1R
    Authors:
    Justyna Gogola-Mruk, Marta Hoffmann-Młodzianowska, Kinga Kamińska, Anna Ptak
    Academic press:
    Toxicology (rok: 2021, tom: 452, strony: 152715), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2021.152715 - link to the publication
  4. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Academic press:
    Chemosphere (rok: 2019, tom: 217, strony: 100-110), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2018.11.018. - link to the publication
  1. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate proliferation of granulosa tumor via IGF1R – 3D cell culture model
    Authors:
    Justyna Gogola, Marta Hoffmann and Anna Ptak
    Conference:
    LINZ 2018 - EUSAAT 2018; 21st European Congress on Alternatives to Animal Testing - 18th Annual Congress of EUSAAT (rok: 2018, ), Wydawca: Springer Spektrum
    Data:
    konferencja 23-26 wrzesień
    Status:
    Published
  2. The mixture of persistent organic pollutants present in human follicular fluid stimulates the estradiol secretion by adult granulosa tumor spheroids via the classic and non-classic estrogen receptors
    Authors:
    Gogola J, Hoffmann M, Nimpsz N, Ptak A
    Conference:
    55th Congress of the European Societies of Toxicology (EUROTOX 2019) (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 8-11 wrzesień
    Status:
    Published
  3. Endocrine-disrupting chemicals present in human follicular fluid disrupt granulosa cell tumors E2 secretion dependent on estrogen metabolism potential
    Authors:
    Gogola J, Hoffmann M, Nimpsz S, Ptak A
    Conference:
    21st European Congress on Gynaecological Oncology (ESGO 2019) (rok: 2019, ), Wydawca: BMJ Journals
    Data:
    konferencja 2-5 listopad
    Status:
    Published
  4. Persistent endocrine-disrupting chemicals in human follicular fluid stimulate proliferation in granulosa tumor spheroids
    Authors:
    Gogola J, Hoffmann M, Ptak A
    Conference:
    38th International Symposium on Halogenated Persistent Organic Pollutants (POPs) & 10th International PCB Workshop : DIOXIN 2018 (rok: 2018, ), Wydawca: Organohalogen Compounds
    Data:
    konferencja 26-31 sierpień
    Status:
    Published

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