Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pathophysiology of granulomatosis with polyangiitis (GPA) - extracellular vesicles and RNA transport

2016/21/D/NZ6/02123

Keywords:

neutrophil extracellula vesicles granulomatosis with polyangiitis miRNA mRNA

Descriptors:

  • NZ1_1: Molecular biology
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Surmiak 

Number of co-investigators in the project: 3

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 616 133 PLN

Project start date (Y-m-d): 2017-02-06

Project end date (Y-m-d): 2020-01-05

Project duration:: 35 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zbiornik do przechowywania próbek w ciekłym azocie.
  2. blok grzewczy (termoblok) - z wkładem na probówki 1,5-2ml (3 500 PLN)
  3. Mikrowirówka.
  4. komplet pipet.
  5. Uniwersalna wirówka laboratoryjna z chłodzeniem (44 000 PLN)
  6. Wytrząsarka kołyskowa (kołyska laboratoryjna) (1 799 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis
    Authors:
    Marcin Surmiak , Anna Gielicz , Darko Stojkov , Rafał Szatanek , Katarzyna Wawrzycka-Adamczyk , Shida Yousefi , Hans-Uwe Simon , Marek Sanak
    Academic press:
    The Journal of Lipid Research (rok: 2020, tom: 61(1), strony: 45300), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.M092072. - link to the publication
  2. Endothelial cells response to neutrophil-derived extracellular vesicles miRNAs in anti-PR3 positive vasculitis
    Authors:
    Marcin Surmiak, Joanna Kosałka-Węgiel, Stanisław Polański, Marek Sanak
    Academic press:
    Clinical & Experimental Immunology (rok: 2021, tom: 204, strony: 267-282), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cei.13581 - link to the publication
  3. Profile of circulating extracellular vesicles microRNA correlates with the disease activity in granulomatosis with polyangiitis
    Authors:
    Marcin Surmiak, Katarzyna Wawrzycka-Adamczyk, Joanna Kosałka-Węgiel, Stanisław Polański, Marek Sanak
    Academic press:
    Clinical and Experimental Immunology (rok: 2022, ), Wydawca: Oxford Academic
    Status:
    Accepted for publication
    DOI:
    10.1093/cei/uxac022 - link to the publication
  1. Circulating extracellular vesicles from patients with granulomatosis with polyangiitis stimulate neutrophils to generate reactive oxygen species and neutrophil extracellular traps
    Authors:
    Marcin Surmiak, Anna Gielicz, Darko Stojkov, Rafał Szatanek, Katarzyna Wawrzycka-Adamczyk, Shida Yousefi, Hans-Uwe Simon, Jacek Musiał, Marek Sanak
    Conference:
    5th European Congress of Immunology (Amsterdam) (rok: 2018, ), Wydawca: Wiener Medizinische Akademie GmbH
    Data:
    konferencja 2-5.09
    Status:
    Published
  2. Clathrin-mediated endocytosis inhibitor can limit activation of neutrophils by plasma derived extracellular vesicles from patients with granulomatosis with polyangiitis
    Authors:
    Marcin Surmiak, Joanna Kosałka, Rafał Szatanek, Marek Sanak
    Conference:
    xMAP CONNECT 2019 (rok: 2019, ), Wydawca: Luminex
    Data:
    konferencja 5-6 November
    Status:
    Published
  3. Molecular handprints of neutrophils activated by plasma derived extracellular vesicles from patients with granulomatosis with polyangiitis
    Authors:
    Marcin Surmiak, Joanna Kosałka, Marek Sanak
    Conference:
    World Immune Regulation Meeting XIII (rok: 2019, ), Wydawca: SIAF
    Data:
    konferencja 6-9 April
    Status:
    Published
  4. Molecular background of endothelial cells activation mediated by extracellular vesicles isolated from plasma of patients with granulomatosis with polyangiitis
    Authors:
    Marcin Surmiak, Joanna Kosałka, Agnieszka Grabowska, Marek Sanak
    Conference:
    World Immune Regulation Meeting XIII (Davos, Switzerland) (rok: 2019, ), Wydawca: SIAF
    Data:
    konferencja 6-9 April
    Status:
    Published
  5. Pro-survival phenotype of human endothelial cells exposed to neutrophil-derived extracellular vesicles
    Authors:
    Marcin Surmiak, Stanisław Polański, Joanna Kosałka, Marek Sanak
    Conference:
    5th European Congress of Immunology (Amsterdam) (rok: 2018, ), Wydawca: Wiener Medizinische Akademie GmbH
    Data:
    konferencja 2-5.09
    Status:
    Published

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