Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Multi-domain proteins with disordered linkers in cellulose decomposition and cell adhesion

2016/21/B/NZ1/00006

Keywords:

multi-domain proteins intrinsically disordered proteins adhesion proteins enzymes cellulose molecular dynamics simulations coarse-grained models

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_1: Molecular biology
  • ST4_7: Electrochemistry, microfluidics in chemistry, sensors

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Fizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Bartosz Różycki 

Number of co-investigators in the project: 2

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 278 400 PLN

Project start date (Y-m-d): 2017-01-12

Project end date (Y-m-d): 2020-10-11

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Serwer komputerowy (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  • Book publications / chapters in book publications (3)
  1. Influence of lipid rafts on pattern formation during T-cell adhesion
    Authors:
    Long Li, Jinglei Hu, Bartosz, Różycki, Xiaohuan Wang, Helong Wu, Fan Song
    Academic press:
    New Journal of Physics (rok: 2021, tom: 23, strony: 43052), Wydawca: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1367-2630/abeacb - link to the publication
  2. Structural analysis of phosphatidylinositol 4-kinase III beta (PI4KB)-14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro
    Authors:
    Dominika Chalupska, Andrea Eisenreichova, Bartosz Różycki, Lenka Rezabkova, Jana Humpolickova, Martin Klima, Evzen Boura
    Academic press:
    Journal of Structural Biology (rok: 2017, tom: 200, strony: 36-44), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsb.2017.08.006 - link to the publication
  3. The length but not the sequence of peptide linker modules exerts the primary influence on the conformations of protein domains in cellulosome multi-enzyme complexes
    Authors:
    Bartosz Różycki, Pierre-André Cazade, Shane O'Mahony, Damien Thompson, Marek Cieplak
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2017, tom: 19, strony: 21414-21425), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7CP04114D - link to the publication
  4. Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization
    Authors:
    Andrés M. Vera, Albert Galera-Prat, Michał Wojciechowski, Bartosz Różycki, Douglas V. Laurents, Mariano Carrión-Vázquez, Marek Cieplak and Philip Tinnefeld
    Academic press:
    Structure (rok: 2021, tom: 29, strony: 587-597), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.str.2021.01.006 - link to the publication
  5. Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
    Authors:
    Long Li, Jinglei Hu, Bartosz Różycki, Fan Song
    Academic press:
    Nano Letters (rok: 2020, tom: 20, strony: 722-728), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.nanolett.9b04596 - link to the publication
  6. Pseudo-Improper-Dihedral Model for Intrinsically Disordered Proteins
    Authors:
    Łukasz Mioduszewski, Bartosz Różycki, Marek Cieplak
    Academic press:
    Journal of Chemical Theory and Computation (rok: 2020, tom: 16, strony: 4726-4733), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jctc.0c00338 - link to the publication
  7. Structural insights into Acyl-coenzyme A binding domain containing 3 (ACBD3) protein hijacking by picornaviruses
    Authors:
    Dominika Chalupska, Bartosz Różycki, Martin Klima, Evzen Boura
    Academic press:
    Protein Science (rok: 2019, tom: 28, strony: 2073-2079), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/pro.3738 - link to the publication
  8. Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3
    Authors:
    Alessandro Sicorello, Bartosz Różycki, Petr V. Konarev, Dmitri I. Svergun, Annalisa Pastore
    Academic press:
    Structure (rok: 2021, tom: 29, strony: 45303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.str.2020.09.010 - link to the publication
  9. Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites
    Authors:
    Vladimira Horova, Heyrhyoung Lyoo, Bartosz Różycki, Dominika Chalupska, Miroslav Smola, Jana Humpolickova, Jeroen RPM Strating, Frank JM van Kuppeveld, Evzen Boura, Martin Klima
    Academic press:
    PLOS Pathogens (rok: 2019, tom: 15, strony: e1007962), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1007962 - link to the publication
  10. Dual binding in cohesin-dockerin complexes: the energy landscape and the role of short, terminal segments of the dockerin module
    Authors:
    Michał Wojciechowski, Bartosz Różycki, Pham Dinh Quoc Huy, Mai Suan Li, Edward Bayer, Marek Cieplak
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 5051), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-23380-9 - link to the publication
  11. Phosphatidylinositol 4-kinase IIIbeta (PI4KB) forms highly flexible heterocomplexes that include ACBD3, 14-3-3, and Rab11 proteins
    Authors:
    Dominika Chalupska, Bartosz Różycki, Jana Humpolickova, Lenka Faltova, Martin Klima, Evzen Boura
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 567), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-37158-6 - link to the publication
  12. Interplay between cooperativity of intercellular receptor-ligand binding and coalescence of nanoscale lipid clusters in adhering membranes
    Authors:
    Long Li, Jinglei Hu, Xinghua Shi, Bartosz Różycki, Fan Song
    Academic press:
    Soft Matter (rok: 2021, tom: 17, strony: 1912-1920), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D0SM01904F - link to the publication
  13. Konformacje białek wielodomenowych i częściowo nieustrukturyzowanych - symulacje i eksperymenty
    Authors:
    Bartosz Różycki
    Academic press:
    Postępy Biochemii (rok: 2017, tom: 63, strony: 132-136), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  14. Disordered peptide chains in an alpha-C-based coarse-grained model
    Authors:
    Łukasz Mioduszewski, Marek Cieplak
    Academic press:
    Physical Chemistry Chemical Physics (rok: 2018, tom: 20, strony: 19057-19070), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8CP03309A - link to the publication
  15. Membrane fluctuations and acidosis regulate cooperative binding of 'marker of self' protein CD47 with the macrophage checkpoint receptor SIRPalpha
    Authors:
    Jan Steinkühler, Bartosz Różycki, Cory Alvey, Reinhard Lipowsky, Thomas R. Weikl, Rumiana Dimova, Dennis E. Discher
    Academic press:
    Journal of Cell Science (rok: 2019, tom: 132, strony: 216770), Wydawca: Company of Biologists
    Status:
    Published
    DOI:
    10.1242/jcs.216770 - link to the publication
  1. Binding and segregation of proteins in membrane adhesion: Theory, modelling, and simulations
    Authors:
    Thomas R. Weikl, Jinglei Hu, Batuhan Kav, Bartosz Różycki
    Book:
    Multiresponsive Behavior of Biomembranes and Giant Vesicles. Advances in Biomembranes and Lipid Self-Assembly. (rok: 2019, tom: 30, strony: 159-194), Wydawca: Elsevier
    Status:
    Published
  2. Inferring structural ensembles of flexible and dynamic macromolecules using Bayesian, maximum entropy, and minimal-ensemble refinement methods
    Authors:
    Jürgen Köfinger, Bartosz Różycki, Gerhard Hummer
    Book:
    Biomolecular Simulations: Methods and Protocols. Methods in Molecular Biology. (rok: 2019, tom: 2022, strony: 341-352), Wydawca: Springer
    Status:
    Published
  3. Structures of Dynamic Protein Complexes: Hybrid Techniques to Study MAP Kinase Complexes and the ESCRT System
    Authors:
    Wolfgang Peti, Rebecca Page, Evzen Boura, and Bartosz Różycki
    Book:
    Protein NMR: Methods and Protocols. Methods in Molecular Biology. (rok: 2018, tom: 1688, strony: 375-389), Wydawca: Springer
    Status:
    Published

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