Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Neurodevelopmental patomechanisms of triclocarban- and dichlorodiphenyldichloroetylene-induced effects: the role of apoptosis and autophagy as well as the receptor signaling pathways for estrogens, aryl hydrocarbons, and androstane

2015/19/B/NZ7/02449

Keywords:

neurotoxicity apoptosis estrogen receptors aryl hydrocarbon receptor constitutive androstane receptor environmental pollutants endocrine disrupting compounds

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_1: Etiology of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Kajta 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 745 000 PLN

Project start date (Y-m-d): 2016-06-20

Project end date (Y-m-d): 2019-06-19

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Homogenizator ultradźwiękowy (20 000 PLN)
  2. Urządzenie do odciągania i odsysania płynów.
  3. Komora UV do przygotowywania próbek do analiz PCR (13 000 PLN)
  4. Pojemnik na ciekły azot (12 000 PLN)
  5. Łaźnia wodna.
  6. Mieszadło magnetyczne.

Information in the final report

  • Publication in academic press/journals (4)
  1. Autophagy-related neurotoxicity is mediated via AHR and CAR in mouse neurons exposed to DDE
    Authors:
    Wnuk A, Rzemieniec J, Przepiórska K, Wesołowska J, Wójtowicz AK, Kajta M.
    Academic press:
    Sci Total Environ (rok: 2020, tom: 742, strony: 140599), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scitotenv.2020.140599 - link to the publication
  2. Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosi
    Authors:
    Kajta M, Wnuk A, Rzemieniec J, Lason W, Mackowiak M, Chwastek E, Staniszewska M, Nehring I, Wojtowicz AK
    Academic press:
    Mol Neurobiol (rok: 2019, tom: 56, strony: 3113-3131), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1285-4 - link to the publication
  3. Triclocarban impairs autophagy in neuronal cells and disrupts estrogen receptor signaling via hypermethylation of specific genes
    Authors:
    Kajta M, Rzemieniec J, Wnuk A, Lasoń W
    Academic press:
    Sci Total Environ (rok: 2020, tom: 701, strony: 134818), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scitotenv.2019.134818. - link to the publication
  4. Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System
    Authors:
    Wnuk A, Kajta M
    Academic press:
    Int J Mol Sci (rok: 2017, tom: 18, strony: 2394; 1-26), Wydawca: Int J Mol Sci, MDPI journal
    Status:
    Published
    DOI:
    10.3390/ijms18112394 - link to the publication

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