Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The influence of a new hybryd compound derived from 2-(2,5-dioxopyrrolidin-1-yl) propanamide on hippocampal neuroprotection and neurogenesis in a mouse pilocarpine model of epilepsy

2015/19/B/NZ7/03694

Keywords:

pilocarpine antiepileptic drugs neuroprotection neurogenesis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Wsi im. Witolda Chodźki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marta Andres-Mach 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 593 400 PLN

Project start date (Y-m-d): 2016-07-20

Project end date (Y-m-d): 2021-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wytrząsarka orbitalna (5 000 PLN)
  2. Łaźnia wodna (7 000 PLN)
  3. Basen Morrisa (120 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. C-11, a New Antiepileptic Drug Candidate: Evaluation of the Physicochemical Properties and Impact on the Protective Action of Selected Antiepileptic Drugs in the Mouse Maximal Electroshock-Induced Seizure Model.
    Authors:
    Zagaja M, Szewczyk A, Szala-Rycaj J, Raszewski G, Chrościńska-Krawczyk M, Abram M, Kamiński K, Andres-Mach M.
    Academic press:
    Molecules (rok: 2021, tom: 26(11), strony: 3144), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26113144. - link to the publication
  2. Increased neurogenesis after ACEA and levetiracetam treatment in mouse pilocarpine model of epilepsy
    Authors:
    Mirosław Zagaja, Aleksandra Szewczyk, Agnieszka Haratym-Maj, Radosław Rola, Maciej Maj, Jarogniew Luszczki, Marta Andres-Mach
    Academic press:
    Journal of Clinical and Pre-Clinical Research (rok: 2017, tom: 2/2017 vol. 11, strony: 136–141), Wydawca: Institute of Rural Health
    Status:
    Published
    DOI:
    10.26444/jpccr/81283 - link to the publication
  3. Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice
    Authors:
    Andres-Mach M, Szewczyk A, Zagaja M,Szala-Rycaj J, Lemieszek M, Maj M, Abram M, Kaminski K.
    Academic press:
    International journal of Molecular Science (rok: 2021, tom: 22(6), strony: 3240), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063240 - link to the publication
  4. Levetiracetam combined with ACEA, highly selective cannabinoid CB1 receptor agonist changes neurogenesis in mouse brain.
    Authors:
    Zagaja M, Haratym-Maj A, Szewczyk A, Rola R, Maj M, Łuszczki JJ, Andres-Mach M.
    Academic press:
    Neuroscience Letters (rok: 2019, tom: 23, strony: 79-86), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neulet.2018.12.016 - link to the publication
  5. Effect of lacosamide and ethosuximide chronic treatment on neural precursor cells and cognitive functions after pilocarpine induced status epilepticus in mice.
    Authors:
    Szewczyk, A., Zagaja, M., Szala-Rycaj, J., Maj, M., Andres-Mach, M.
    Academic press:
    Brain Science (rok: 2021, tom: 11(8), strony: 1014), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci11081014 - link to the publication
  6. Evaluation of the impact of compound C11 a new anticonvulsant candidate on cognitive functions and hippocampal neurogenesis in mouse brain.
    Authors:
    Andres-Mach M, Szewczyk A, Zagaja M, Luszczki J, Maj M, Rola R, Abram M, Kaminski K.
    Academic press:
    Neuropharmacology (rok: 2020, tom: 163, strony: 107849), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2019.107849 - link to the publication

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