Projects funded by the NCN
Phosphorylation of translation initiation factor eIF2alpha as regulator of synthesis of proinflammatory and signaling cytokines in leukemia cells; role in autocrin activation of JAK/STAT pathways and therapy resistance.
2015/19/N/NZ3/02267
Keywords:
BCR-ABL chronic myeloid leukemia eIF2alpha STAT JAK cytokines IL-4 IL-5 IL-6 IL-13 GMCSF
Descriptors:
- NZ3_1: Cell biology
- NZ3_7: Signal transduction
- NZ3_2: Cell physiology
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 10 - announced on 2015-09-15
Amount awarded: 100 000 PLN
Project start date (Y-m-d): 2016-08-05
Project end date (Y-m-d): 2018-08-04
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Targeting integrated stress response with ISRIB combined with imatinib treatment attenuates RAS/RAF/MAPK and STAT5 signaling and eradicates chronic myeloid leukemia cellsAuthors:Wioleta Dudka, Grazyna Hoser, Shamba S Mondal, Laura Turos-Korgul , Julian Swatler, Monika Kusio-Kobialka, Magdalena Wołczyk , Agata Klejman , Marta Brewinska-Olchowik , Agata Kominek , Milena Wiech , Marcin M Machnicki , Ilona Seferynska , Tomasz Stoklosa , Katarzyna PiwockaAcademic press:BMC Cancer (rok: 2022, tom: 2, strony: 45308), Wydawca: Springer NatureStatus:PublishedDOI:10.1186/s12885-022-10289-w - link to the publication