Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Emerging spectroscopic technologies in diagnosis and treatment of cancer by Raman-IR-SNOM-AFM-femtosecond scpectroscopy- from single cell to human brain and breast tissue.

2015/19/B/ST4/01878

Keywords:

molecular spectroscopy modern diagnostics methods of human brain and mammary gland cancers MCF10A MCF7 MDA-MB231 U87MG

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_2: Spectroscopic and spectrometric techniques

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Halina Abramczyk 

Number of co-investigators in the project: 9

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 947 336 PLN

Project start date (Y-m-d): 2016-07-08

Project end date (Y-m-d): 2020-07-07

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. sonda do pomiarów ramanowskich z elementami do sprzęgania ze spektrometrem i systemem video-mikroskopowym (210 000 PLN)
  2. diody do pomiarów femtosekundowych (10 400 PLN)
  3. komputer.
  4. moduł do charakteryst. wiązki laser-Camera Beam.
  5. obiektyw do pomiaru w cieczach (20 650 PLN)
  6. obiektyw długodystansowy 50X WD:9.00mm (14 200 PLN)
  7. sonda do pomiarów ramanowskich (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  • Articles in post-conference publications (6)
  • Book publications / chapters in book publications (1)
  1. Angiogenesis - a crucial step in breast cancer growth, progression and dissemination by Raman imaging
    Authors:
    Monika Kopeć, Halina Abramczyk
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2018, tom: 198, strony: 338–345), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2018.02.058 - link to the publication
  2. Apical-basal polarity of epithelial cells imaged by Raman microscopy and Raman imaging: Capabilities and challenges for cancer research
    Authors:
    H. Abramczyk, B. Brozek-Pluska
    Academic press:
    Journal of Molecular Liquids (rok: 2017, tom: 245, strony: 52–61), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2017.05.142 - link to the publication
  3. Novel strategies of Raman imaging for exploring cancer lipid reprogramming
    Authors:
    H. Abramczyk, A. Imiela, A. Śliwińska
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 274, strony: 52-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.082 - link to the publication
  4. Photostability of biological systems—Femtosecond dynamics of zinc tetrasulfonated phthalocyanine at cancerous and noncancerous human Breast tissues
    Authors:
    H. Abramczyk, B. Brozek-Pluska, J. Surmacki, M. Tondusson, E.Freysz
    Academic press:
    Journal of Photochemistry and Photobiology A: Chemistry (rok: 2017, tom: 332, strony: 10–24), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotochem.2016.08.012 - link to the publication
  5. Surface-Enhanced Raman Spectroscopy Analysis of Human Breast Cancer via Silver Nanoparticles: An Examination of Fabrication Methods
    Authors:
    Beata Brozek-Pluska , Monika Kopec, Jakub Surmacki
    Academic press:
    Journal of Spectroscopy (rok: 2018, tom: 2018, strony: Article ID 4893274, 8 pages), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/4893274 - link to the publication
  6. The biochemical, nanomechanical and chemometric signatures of brain cancer
    Authors:
    H. Abramczyk, A. Imiela
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2018, tom: 188, strony: 8–19), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.06.037 - link to the publication
  7. Novel strategies of Raman imaging for monitoring the therapeutic benefit of temozolomide in glioblastoma
    Authors:
    A. Imiela , J. Surmacki , H. Abramczyk
    Academic press:
    Journal of Molecular Structure (rok: 2020, tom: 1217, strony: 128381), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2020.128381 - link to the publication
  8. Novel strategies of Raman imaging for brain tumor research
    Authors:
    A. Imiela, B. Polis , L. Polis, H. Abramczyk
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 85290-85310), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.19668 - link to the publication
  9. Histochemical analysis of human breast tissue samples by IR and Raman spectroscopies. Protocols discussion
    Authors:
    Beata Brozek-Pluska, Monika Kopec, Jakub Surmacki, Halina Abramczyk
    Academic press:
    Infrared Physics & Technology (rok: 2018, tom: 93, strony: 247–254), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.infrared.2018.08.005 - link to the publication
  10. Advances in Raman imaging combined with AFM and fluorescence microscopy are beneficial for oncology and cancer research
    Authors:
    H. Abramczyk, A. Imiela, B. Brozek-Pluska, M. Kopec M
    Academic press:
    Nanomedicine Future Medicine (rok: 2019, tom: 14, strony: 1873-1888), Wydawca: Future Medicine Ltd
    Status:
    Published
    DOI:
    10.2217/nnm-2018-0335 - link to the publication
  11. Monitoring glycosylation metabolism in brain and breast cancer by Raman imaging
    Authors:
    M. Kopec, A. Imiela, H. Abramczyk
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45304), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-36622-7 - link to the publication
  12. Polarized Raman microscopy imaging: Capabilities and challenges for cancer research
    Authors:
    Abramczyk H., Brozek-Pluska B., Kopec M.
    Academic press:
    Journal of Molecular Liquids (rok: 2018, tom: 259, strony: 102–111), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2018.03.016 - link to the publication
  13. Development of a new diagnostic Raman method for monitoring epigenetic modifications in the cancer cells of human breast tissue
    Authors:
    Beata Brozek-Pluska, Monika Kope´c and Halina Abramczyk
    Academic press:
    Analytical Methods (rok: 2016, tom: 8, strony: 8542–8553), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6ay02559e - link to the publication
  14. Novel strategies of Raman imaging for monitoring the therapeutic benefit of temozolomide in glioblastoma
    Authors:
    Anna Imiela, Jakub Surmacki, H. Abramczyk
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 1217, strony: 128381), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2020.128381 - link to the publication
  15. Raman spectroscopy for medulloblastoma
    Authors:
    Bartosz Polis, Anna Imiela, Lech Polis, Halina Abramczyk
    Academic press:
    Child's Nervous System (rok: 2018, tom: 34, strony: 2425–2430), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00381-018-3906-7 - link to the publication
  1. Nanooncology: Raman imaging and atomic force microscopy as a tool for proteomic, lipidomic, glycomic, epigenetic stu dies. The biochemical, nanomechanical and chemometric signatures of brain, breast and colon cancers
    Authors:
    H. Abramczyk, M. Kopeć, B. Brożek-Płuska, A. Imiela
    Conference:
    XIV th INTERNATIONAL CONFERENCE ON MOLECULAR SPECTROSCOPY From Molecules to Functional Materials (rok: 2017, ), Wydawca: AGH-University of Science and Technology, Kraków, Poland
    Data:
    konferencja 42981
    Status:
    Published
  2. Spektroskopia Ramana, obrazowanie Ramana oraz obrazowanie fluorescencyjne w analizie układów biologicznych-możliwości i perspektywy
    Authors:
    M. Kopeć, J. Surmacki, B. Brożek-Płuska, H. Abramczyk, A. K. Olejnik, A. Kaufman-Szymczyk, K. Lubecka-Pietruszewska, K. Fabianowska-Majewska, J. Musiał, R. Kordek
    Conference:
    Wała Wielka Nauka (rok: 2016, ), Wydawca: Politechnika Łódzka
    Data:
    konferencja 9-10 Grudnia
    Status:
    Published
  3. Nanooncological ptatform as a tool for proteomic, lipidomic, glycomic, epigenetic studies.
    Authors:
    H. Abramczvk, M. Kopec, J. Surmacki, B. Brozek-Pluska
    Conference:
    Bioinfomics 2019 (rok: 2019, ), Wydawca: Bioinfomics 2019
    Data:
    konferencja 2019-10-24-27
    Status:
    Published
  4. Label-free optical analysis of human brain cancer cells
    Authors:
    B.Brozek-Pluska, A. Imiela, J. Surmacki, H. Abramczyk
    Conference:
    SPEC_2018 (rok: 2018, ), Wydawca: 10th SPEC_2018
    Data:
    konferencja 05-10.06.2018
    Status:
    Published
  5. Angiogeneza-przełomowy krok e rozwoju i progresji raka piersi-obrazowanie ramanowskie oraz AFM
    Authors:
    M. Kopeć, B. Brożek-Płuska, H. Abramczyk, J. Musiła, R. Kordek
    Conference:
    V Łodzkie Sympozjum Doktorantów Chemii (rok: 2017, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 11-12 Maja
    Status:
    Published
  6. Linear and Non-linear Optics in Cancer Research
    Authors:
    H. Abramczyk, A. Jarota, A. Imiela, J, Surmacki
    Conference:
    International Conference on Molecular Spectroscopy (rok: 2019, ), Wydawca: Institute of Low Temperature and Structure Research of the Polish Academy of Science Wroclaw
    Data:
    konferencja 2019- 09-15-19
    Status:
    Published
  1. Applications of Raman scattering in biomedicine, telecommunication and thermography
    Authors:
    H. Abramczyk, M. Kopeć
    Book:
    Measurement Automation Monitoring (rok: 2017, tom: 63, strony: 38-40), Wydawca: PAK
    Status:
    Published

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