Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Double stranded probes, in which both oligonucleotide components hybridize according to the Hoogsteen's interactions, and containing P-stereodefined phosphorothioate oligonucleotides made of DNA, RNA, (2'-OMe)-RNA and/or LNA units - synthesis and hybridizing properties towards DNA and RNA matrices.

2015/19/B/ST5/03116

Keywords:

phosphorothioate oligonucleotides parallel triplexes DNA RNA (2'-OMe)-RNA LNA

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Guga 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 684 400 PLN

Project start date (Y-m-d): 2016-07-14

Project end date (Y-m-d): 2021-07-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kulometr.
  2. APARAT DO ZAUTOMATYZOWANEJ CHROMATOGRAFII ŻELOWEJ TYPU "FLASH" z detektorem UV/ELSD i zaawansowaną obróbką sygnału (190 000 PLN)
  3. Wyparka rotacyjna HEI-VAP.

Information in the final report

  • Publication in academic press/journals (3)
  1. Synthesis and hybridizing properties of P-stereodefined chimeric [PS]-{DNA:RNA} and [PS]- {DNA:(2'-OMe)-RNA} oligomers.
    Authors:
    Katarzyna Jastrze˛bska, Anna Maciaszek, Rafał Dolot, Agnieszka Tomaszewska-Antczak, Barbara Mikołajczyk, Piotr Guga
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 26815-26824), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d2ra04855h - link to the publication
  2. LNA Units Present in [Rp-PS]-(DNA#LNA) Chimeras Enhance the Thermal Stability of Parallel Duplexes and Triplexes Formed with (2'-OMe)-RNA Strands
    Authors:
    Katarzyna Jastrzębska, Barbara Mikołajczyk and Piotr Guga
    Academic press:
    RSC Advances (rok: 2020, tom: 10, strony: 22370-22376), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0ra03934a - link to the publication
  3. P-stereocontrolled synthesis of oligo(nucleoside N3'-O5' phosphoramidothioate)s - opportunities and limitations
    Authors:
    Ewa Radzikowska,Renata Kaczmarek, Dariusz Korczyński, Agnieszka Krakowiak, Barbara Mikołajczyk, Janina Baraniak, Piotr Guga, Kraig A. Wheeler, Tomasz Pawlak, Barbara Nawrot
    Academic press:
    RSC Advances (rok: 2020, tom: 10, strony: 35185-35197), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0ra04987e - link to the publication

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