Double stranded probes, in which both oligonucleotide components hybridize according to the Hoogsteen's interactions, and containing P-stereodefined phosphorothioate oligonucleotides made of DNA, RNA, (2'-OMe)-RNA and/or LNA units - synthesis and hybridizing properties towards DNA and RNA matrices.
2015/19/B/ST5/03116
Keywords
Descriptors
- ST5_16: Chemia biologiczna
Panel
ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution
Centrum Badań Molekularnych i Makromolekularnych PAN
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 10 – announced on 2015-09-15
- Amount awarded
- 684 400 PLN
- Project start date
- 2016-07-14
- Project end date
- 2021-07-13
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- APARAT DO ZAUTOMATYZOWANEJ CHROMATOGRAFII ŻELOWEJ TYPU "FLASH" z detektorem UV/ELSD i zaawansowaną obróbką sygnału. Cost: 190 000 PLN
- Kulometr.
- Wyparka rotacyjna HEI-VAP.
Information in the final report
Publication in academic press/journals (3)
-
LNA Units Present in [Rp-PS]-(DNA#LNA) Chimeras Enhance the Thermal Stability of Parallel Duplexes and Triplexes Formed with (2'-OMe)-RNA Strands
- Authors:
- Katarzyna Jastrzębska, Barbara Mikołajczyk and Piotr Guga
- Academic press:
- RSC Advances (year: 2020, volume: 10, pages: 22370-22376), Publisher: Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/d0ra03934a – link to the publication
-
Synthesis and hybridizing properties of P-stereodefined chimeric [PS]-{DNA:RNA} and [PS]- {DNA:(2'-OMe)-RNA} oligomers.
- Authors:
- Katarzyna Jastrze˛bska, Anna Maciaszek, Rafał Dolot, Agnieszka Tomaszewska-Antczak, Barbara Mikołajczyk, Piotr Guga
- Academic press:
- RSC Advances (year: 2022, volume: 12, pages: 26815-26824), Publisher: Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/d2ra04855h – link to the publication
-
P-stereocontrolled synthesis of oligo(nucleoside N3'-O5' phosphoramidothioate)s - opportunities and limitations
- Authors:
- Ewa Radzikowska,Renata Kaczmarek, Dariusz Korczyński, Agnieszka Krakowiak, Barbara Mikołajczyk, Janina Baraniak, Piotr Guga, Kraig A. Wheeler, Tomasz Pawlak, Barbara Nawrot
- Academic press:
- RSC Advances (year: 2020, volume: 10, pages: 35185-35197), Publisher: Royal Society of Chemistry
- Status:
- Published
- DOI:
- 10.1039/d0ra04987e – link to the publication