Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular mechanism of the toxicity of the antifungal antibiotic amphotericin B

2015/19/B/NZ7/02159

Keywords:

amphotericin B polyene antibiotics biomembranes medical biophysics molecular spectroscopy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Matematyki, Fizyki i Informatyki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wiesław Gruszecki 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 844 200 PLN

Project start date (Y-m-d): 2016-06-15

Project end date (Y-m-d): 2020-06-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny z monitorem.
  2. Laser 405 nm do mikroskopowego systemu ramanowskiego (180 000 PLN)
  3. Wyparka rotacyjna.

Information in the final report

  • Publication in academic press/journals (6)
  1. Molecular organization, localization and orientation of antifungal antibiotic amphotericin B in a single lipid bilayer
    Authors:
    Wojciech Grudzinski, Joanna Sagan, Renata Welc, Rafal Luchowski, Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: Article Number: 32780), Wydawca: NATURE PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.1038/srep32780 - link to the publication
  2. Self-assembly, stability and conductance of amphotericin B channels: bridging the gap between structure and function
    Authors:
    Joanna Zielińska, Miłosz Wieczór, Paweł Chodnicki, Ewa Grela, Rafał Luchowski, Łukasz Nierzwicki, Tomasz Bączek, Wiesław I. Gruszecki and Jacek Czub
    Academic press:
    Nanoscale (rok: 2021, tom: 13, strony: 3686-3697), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d0nr07707k - link to the publication
  3. Imaging of human cells exposed to an antifungal antibiotic amphotericin B reveals the mechanisms associated with the drug toxicity and cell defence
    Authors:
    Ewa Grela, Mateusz Piet, Rafal Luchowski, Wojciech Grudzinski, Roman Paduch and Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 14067), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-32301-9 - link to the publication
  4. ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells
    Authors:
    A. Wu,· E. Grela, · K. Wójtowicz, · N. Filipczak,· Y. Hamon, · R. Luchowski, · W. Grudziński,· O. Raducka‑Jaszul, · M. Gagoś, · A. Szczepaniak, · G. Chimini, · W. I. Gruszecki, · T. Trombik
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2019, tom: 76, strony: 4813-5054), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s0001 - link to the publication
  5. Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics
    Authors:
    Ewa Grela, Miłosz Wieczór, Rafał Luchowski, Joanna Zielinska, Angelika Barzycka, Wojciech Grudzinski, Katarzyna Nowak, Piotr Tarkowski, Jacek Czub and Wieslaw I. Gruszecki
    Academic press:
    Molecular Pharmaceutics (rok: 2018, tom: 15, strony: 4202−4213), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00572 - link to the publication
  6. Modes of the antibiotic activity of amphotericin B against Candida albicans
    Authors:
    Ewa Grela, Agnieszka Zdybicka-Barabas, Bozena Pawlikowska-Pawlega, Malgorzata Cytrynska, Monika Wlodarczyk, Wojciech Grudzinski, Rafal Luchowski, Wieslaw I. Gruszecki
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 17029), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-53517-3 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy